Gabapentinoids: Difference between revisions
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[[File:Gabapentinoidsstructure.png|thumbnail|Diagram showing the structural similarities of [[pregabalin]], [[gabapentin]] and [[GABA |gamma-aminobutyric acid]].]] | [[File:Gabapentinoidsstructure.png|thumbnail|Diagram showing the structural similarities of [[pregabalin]], [[gabapentin]] and [[GABA |gamma-aminobutyric acid]].]] | ||
'''Gabapentinoids''' are a class of chemical compounds that are derivatives of [[GABA |gamma-aminobutyric acid]] which block α2δ subunit-containing voltage-dependent calcium [[receptor#Ion_channels |channels]]. While all gabapentinoids block the α2δ channels, they also have unique pharmacological characteristics such as enzyme inhibition. | |||
=See | Gabapentinoids are commonly used for epilepsy, neuropathic pain, and [[restless legs syndrome]]. Gabapentinoids are often [[Sedation |sedating]], have [[Seizure suppression |anticonvulsant]] effects, and [[Anxiety suppression |suppress anxiety]]. Drugs in this class include [[gabapentin]], [[phenibut]] and, [[pregabalin]]. Gabapentinoids can be dangerous when mixed with other [[depressants]] such as [[benzodiazepine |benzodiazepines]], [[alcohol]] and [[opioid |opioids]]. | ||
=See also= | |||
*[[Responsible use]] | *[[Responsible use]] | ||
*[[Depressants]] | *[[Depressants]] | ||
Revision as of 06:38, 23 October 2016
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This article is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it. |
Gabapentinoids are a class of chemical compounds that are derivatives of gamma-aminobutyric acid which block α2δ subunit-containing voltage-dependent calcium channels. While all gabapentinoids block the α2δ channels, they also have unique pharmacological characteristics such as enzyme inhibition.
Gabapentinoids are commonly used for epilepsy, neuropathic pain, and restless legs syndrome. Gabapentinoids are often sedating, have anticonvulsant effects, and suppress anxiety. Drugs in this class include gabapentin, phenibut and, pregabalin. Gabapentinoids can be dangerous when mixed with other depressants such as benzodiazepines, alcohol and opioids.