Nasal spray guide: Difference between revisions
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[[File:Action photo of nasal spray on a black background.jpg|200px|thumbnail|right|Actuation of a nasal spray bottle, used to deliver medication via the nostrils]] | [[File:Action photo of nasal spray on a black background.jpg|200px|thumbnail|right|Actuation of a nasal spray bottle, used to deliver medication via the nostrils]] | ||
After using for a long time I came across inconveniences and solutions. My favorite of which, the (meth)amphetamine [[Routes_of_administration#Nasal_Spray|nasal spray]]. Here's a guide to make your own. | After using for a long time I came across inconveniences and solutions. My favorite of which, the (meth)amphetamine [[Routes_of_administration#Nasal_Spray|nasal spray]]. Methamphetamine is the example compound for this tutorial and is very soluble in water, so while this guide can apply to any substance for which volumetric dosing is desired, different solvents will be required for differing solutes. Here's a guide to make your own. | ||
First of all, you'll need a spray bottle. You can either purchase an empty, easily refillable one or buy a saline solution spray. If you choose the second choice, the bottle most likely won't have a screw cap, so be sure to examine if the top is removable at all. If it is, the easiest way to pop it open is by using a standard bottle opener. | First of all, you'll need a spray bottle. You can either purchase an empty, easily refillable one or buy a saline solution spray. If you choose the second choice, the bottle most likely won't have a screw cap, so be sure to examine if the top is removable at all. If it is, the easiest way to pop it open is by using a standard bottle opener. | ||
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#The salt will act as a decongestant, so you won't have a clogged nose. | #The salt will act as a decongestant, so you won't have a clogged nose. | ||
The choice is yours. When adding salt, never add more than 9mg / mL. I'd recommend just 4mg / mL or so, to reduce | The choice is yours. When adding salt, never add more than 9mg / mL. I'd recommend just 4mg / mL or so, to reduce its influence on the absorption rate. (Bioavailability) | ||
All choices made, except for one, your dosing. Especially for the first time, I'd recommend to not make a lot of solution, since you might not like the method and it's | All choices made, except for one, your dosing. Especially for the first time, I'd recommend to not make a lot of solution, since you might not like the method and it's tricky to get the meth out again. Read this first, before actually making the solution, as I'm explaining that in the next paragraph. | ||
Let's say you used 10mL to determine the amount of sprays and got 90 sprays out of that. A simple calculation (10 / 90) would tell you each spray consists of 0.111mL. Meth is freely soluble in water, so you won't have to worry about it not dissolving when adding too much, but you just need to decide what dose you'd like. Dissolving 1 gram of meth, would get you 100mg / mL and 11.11mg per spray. 1.5g meth > 16.67mg /spray and so on. | Let's say you used 10mL to determine the amount of sprays and got 90 sprays out of that. A simple calculation (10 / 90) would tell you each spray consists of 0.111mL. Meth is freely soluble in water, so you won't have to worry about it not dissolving when adding too much, but you just need to decide what dose you'd like. Dissolving 1 gram of meth, would get you 100mg / mL and 11.11mg per spray. 1.5g meth > 16.67mg /spray and so on. | ||
To make the solution, get some water boiling and let it cool down. Put the desired contents and amounts, chosen from the description above, in the empty bottle and add the amount of distilled water | To make the solution, get some water boiling and let it cool down. Put the desired contents and amounts, chosen from the description above, in the empty bottle and add the amount of distilled water preferred. Add the cap and shake it for a while to mix everything properly. Always shake before use for optimal effect. | ||
==See also== | ==See also== | ||
Revision as of 02:01, 17 October 2016
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After using for a long time I came across inconveniences and solutions. My favorite of which, the (meth)amphetamine nasal spray. Methamphetamine is the example compound for this tutorial and is very soluble in water, so while this guide can apply to any substance for which volumetric dosing is desired, different solvents will be required for differing solutes. Here's a guide to make your own.
First of all, you'll need a spray bottle. You can either purchase an empty, easily refillable one or buy a saline solution spray. If you choose the second choice, the bottle most likely won't have a screw cap, so be sure to examine if the top is removable at all. If it is, the easiest way to pop it open is by using a standard bottle opener.
If you have an open spray bottle, empty it if not yet empty and fill it with a measured amount of water. (eg. 10mL) Put the top back on and count how many sprays you can get out of it until it's empty. Repeat this step and use the average for a more precise dosing.
For the solution there are 2 types to choose from and an optional addition. You could make (1) a solution with only meth in it or (2) a solution with meth and some salt added. Both having its own advantage and disadvantage. Optionally, you could add a sweetener, like sorbitol, to make it taste a bit better. (500mg sorbitol would be plenty for 10mL solution)
Advantages:
- The lack of salt will create a favourable osmotic pressure, causing a higher absorbance.
- The salt will act as a decongestant, so you won't have a clogged nose.
The choice is yours. When adding salt, never add more than 9mg / mL. I'd recommend just 4mg / mL or so, to reduce its influence on the absorption rate. (Bioavailability)
All choices made, except for one, your dosing. Especially for the first time, I'd recommend to not make a lot of solution, since you might not like the method and it's tricky to get the meth out again. Read this first, before actually making the solution, as I'm explaining that in the next paragraph. Let's say you used 10mL to determine the amount of sprays and got 90 sprays out of that. A simple calculation (10 / 90) would tell you each spray consists of 0.111mL. Meth is freely soluble in water, so you won't have to worry about it not dissolving when adding too much, but you just need to decide what dose you'd like. Dissolving 1 gram of meth, would get you 100mg / mL and 11.11mg per spray. 1.5g meth > 16.67mg /spray and so on.
To make the solution, get some water boiling and let it cool down. Put the desired contents and amounts, chosen from the description above, in the empty bottle and add the amount of distilled water preferred. Add the cap and shake it for a while to mix everything properly. Always shake before use for optimal effect.