Warning
This is an unofficial archive of PsychonautWiki as of 2025-08-11T15:14:44Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.

Bromantane: Difference between revisions

From PsychonautWiki Archive
Jump to navigation Jump to search
>Josikins
No edit summary
>Kaylee
No edit summary
Line 7: Line 7:
==Chemistry==
==Chemistry==
{{chemistry}}
{{chemistry}}
[[File:Adamantane.png|100px|thumb|left|Adamantane molecule]]Bromantane is a chemical derivative of adamantane, a polyhedral organic compound. Although hundreds of substances have been derived from adamantane, bromantane remains the most well-studied.<ref>Adamantane derivatives enhancing body's resistance to emergencies. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/10222828</ref> Bromantane's structure consists of adamantane fused with a 4-bromoaniline molecule.
[[File:Adamantane.png|100px|thumb|left|Adamantane molecule]]Bromantane is a chemical derivative of adamantane, a polyhedral organic compound containing four fused cyclohexane rings. Bromantane's structure consists of adamantane bound at R<sub>2</sub> to a nitrogenous group which is in turn bonded to a phenyl ring substituted at R<sub>4</sub> with a bromine group.


==Pharmacology==
==Pharmacology==

Revision as of 10:30, 11 October 2016

This article is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

Bromantane
Chemical Nomenclature
Common names Bromantane, Bromantan, Ladasten
Substitutive name Bromantane
Systematic name N-(4-Bromophenyl)adamantan-2-amine
Class Membership
Psychoactive class Stimulant / Nootropic
Chemical class Adamantane
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Bioavailability 42%[1]
Threshold < 10 mg
Light 10 - 50 mg
Common 50 - 100 mg
Strong 100 - 200 mg
Heavy 200 mg +
Duration
Total 6 - 10 hours
Onset 30 - 60 minutes
Peak 2 - 4 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions

Bromantane (trade name Ladasten / Ладастен) is a Russian pharmaceutical drug developed in the late 1980s that possesses both stimulant and anxiolytic properties.[2] Although it is a commonly used medication in Russia and surrounding countries, it has not gained widespread recognition or pharmaceutical use in other countries. During the 1996 Olympic Games in Atlanta, 5 different Russian athletes tested positive for bromantane use.[3]

A study conducted on human subjects displayed bromantane's ability to improve endurance and work capacity during stressful and intense conditions.[4] This is because bromantane works as an actoprotector, a substance that makes the body more stable under physical duress without increasing oxygen consumption.[5]

Chemistry

This chemistry section is incomplete.

You can help by adding to it.

Adamantane molecule

Bromantane is a chemical derivative of adamantane, a polyhedral organic compound containing four fused cyclohexane rings. Bromantane's structure consists of adamantane bound at R2 to a nitrogenous group which is in turn bonded to a phenyl ring substituted at R4 with a bromine group.

Pharmacology

Bromantane is atypical among stimulants in the sense that it inhibits serotonin reuptake in addition to inhibiting dopamine reuptake. It also increases levels of norepinephrine, but its means of doing so are unclear.[6] Bromantane's anxiolytic properties are due to its strengthening of GABA-ergic mediation.[7]

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

Cognitive effects

Toxicity and harm potential

This toxicity and harm potential section is a stub.

As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
Note: Always conduct independent research and use harm reduction practices if using this substance.

Lethal dosage

The LD50 of bromantane in mice has been established at 8100 mg/kg.[8]

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Russia - Bromantane is a prescription drug in Russia, its country of origin.
  • United States - Bromantane is uncontrolled in the United States, and has not been approved by the FDA for human use. However, this has led nootropic vendor websites to sell bromantane under the label of "not for human consumption."

See also

References

  1. Oliynyk, S., Oh, S. (September 2012). "The Pharmacology of Actoprotectors: Practical Application for Improvement of Mental and Physical Performance". Biomolecules & Therapeutics. 20 (5): 446–456. doi:10.4062/biomolther.2012.20.5.446. ISSN 1976-9148. 
  2. A quantitative pharmaco-electroencephalographic analysis of the action of bromantane. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/8312546
  3. Bromontan, a new doping agent (The Lancet) | http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2805%2963310-7/abstract
  4. The neuro- and psychophysiological effects of bromantane. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/10998997
  5. The Pharmacology of Actoprotectors: Practical Application for Improvement of Mental and Physical Performance (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762282/
  6. The effect of bromantane on the dopamin- and serotoninergic systems of the rat brain. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/7580761
  7. Smarter Nootropics http://www.smarternootropics.com/bromantane/
  8. The characteristics of the neuropsychotropic activity of bromantane in laboratory animals. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/10340117/