
Bromantane: Difference between revisions
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==Chemistry== | ==Chemistry== | ||
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[[File:Adamantane.png|100px|thumb|left|Adamantane molecule]]Bromantane is a chemical derivative of adamantane, a polyhedral organic compound. | [[File:Adamantane.png|100px|thumb|left|Adamantane molecule]]Bromantane is a chemical derivative of adamantane, a polyhedral organic compound containing four fused cyclohexane rings. Bromantane's structure consists of adamantane bound at R<sub>2</sub> to a nitrogenous group which is in turn bonded to a phenyl ring substituted at R<sub>4</sub> with a bromine group. | ||
==Pharmacology== | ==Pharmacology== |
Revision as of 10:30, 11 October 2016
This article is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it. |
Bromantane | |||||||||||||||||||||||||||||
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Chemical Nomenclature | |||||||||||||||||||||||||||||
Common names | Bromantane, Bromantan, Ladasten | ||||||||||||||||||||||||||||
Substitutive name | Bromantane | ||||||||||||||||||||||||||||
Systematic name | N-(4-Bromophenyl)adamantan-2-amine | ||||||||||||||||||||||||||||
Class Membership | |||||||||||||||||||||||||||||
Psychoactive class | Stimulant / Nootropic | ||||||||||||||||||||||||||||
Chemical class | Adamantane | ||||||||||||||||||||||||||||
Routes of Administration | |||||||||||||||||||||||||||||
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Bromantane (trade name Ladasten / Ладастен) is a Russian pharmaceutical drug developed in the late 1980s that possesses both stimulant and anxiolytic properties.[2] Although it is a commonly used medication in Russia and surrounding countries, it has not gained widespread recognition or pharmaceutical use in other countries. During the 1996 Olympic Games in Atlanta, 5 different Russian athletes tested positive for bromantane use.[3]
A study conducted on human subjects displayed bromantane's ability to improve endurance and work capacity during stressful and intense conditions.[4] This is because bromantane works as an actoprotector, a substance that makes the body more stable under physical duress without increasing oxygen consumption.[5]
Chemistry
This chemistry section is incomplete. You can help by adding to it. |

Bromantane is a chemical derivative of adamantane, a polyhedral organic compound containing four fused cyclohexane rings. Bromantane's structure consists of adamantane bound at R2 to a nitrogenous group which is in turn bonded to a phenyl ring substituted at R4 with a bromine group.
Pharmacology
Bromantane is atypical among stimulants in the sense that it inhibits serotonin reuptake in addition to inhibiting dopamine reuptake. It also increases levels of norepinephrine, but its means of doing so are unclear.[6] Bromantane's anxiolytic properties are due to its strengthening of GABA-ergic mediation.[7]
Subjective effects
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.
Physical effects
- Stamina enhancement
- Stimulation
- Dehydration
- Vasoconstriction
- Increased blood pressure
- Muscle relaxation
Cognitive effects
- Anxiety suppression
- Stamina enhancement
- Focus enhancement
- Thought acceleration
- Analysis enhancement
- Wakefulness
- Memory enhancement
- Motivation enhancement
- Cognitive euphoria
Toxicity and harm potential
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This toxicity and harm potential section is a stub. As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. |
Lethal dosage
The LD50 of bromantane in mice has been established at 8100 mg/kg.[8]
It is strongly recommended that one use harm reduction practices when using this drug.
Tolerance and addiction potential
Legal issues
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This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it. |
- Russia - Bromantane is a prescription drug in Russia, its country of origin.
- United States - Bromantane is uncontrolled in the United States, and has not been approved by the FDA for human use. However, this has led nootropic vendor websites to sell bromantane under the label of "not for human consumption."
See also
References
- ↑ Oliynyk, S., Oh, S. (September 2012). "The Pharmacology of Actoprotectors: Practical Application for Improvement of Mental and Physical Performance". Biomolecules & Therapeutics. 20 (5): 446–456. doi:10.4062/biomolther.2012.20.5.446. ISSN 1976-9148.
- ↑ A quantitative pharmaco-electroencephalographic analysis of the action of bromantane. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/8312546
- ↑ Bromontan, a new doping agent (The Lancet) | http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2805%2963310-7/abstract
- ↑ The neuro- and psychophysiological effects of bromantane. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/10998997
- ↑ The Pharmacology of Actoprotectors: Practical Application for Improvement of Mental and Physical Performance (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762282/
- ↑ The effect of bromantane on the dopamin- and serotoninergic systems of the rat brain. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/7580761
- ↑ Smarter Nootropics http://www.smarternootropics.com/bromantane/
- ↑ The characteristics of the neuropsychotropic activity of bromantane in laboratory animals. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/10340117/