DOx

2,5-Dimethoxyamphetamine (2,5-DMA), the base structure of the DOx family.

DOx refers to a group of amphetamines originally synthesized and studied by Alexander Shulgin. Shulgin created most of these substances in the 1970s and later published his findings in his book PiHKAL. The DOx chemicals are highly potent, long lasting and dose-sensetive and are considered more intense than their counterpart 2C-x family, with strong visuals and an intense body load.

Examples

• ALEPH
• ALEPH-2
• ALEPH-7
• DOB
• DOC
• DOE
• DOI
• DOM

Health effects, potential addiction and tolerance

The DOx chemicals, as with many other serotonergic psychedelics, should not be taken in combination with SSRIs (selective serotonin reuptake inhibitors) or tricyclic antidepressants in general to avoid serotonin syndrome, a potentially life-threatening condition in which an abundance of serotonin is built up the body, causing many physical and cognitive health problems.

Legal issues

• USA: In the US, some of the DOx chemicals are listed as Schedule I substances and all others under the Federal Analog Act.
• Australia: Australia has a blanket ban over all substituted phenethylamines including the entire DOx family.
• Switzerland: DOM, DOB and DOET are illegal to possess, produce and sell.

See also

• Responsible use
• 2C-x
• 25x-NBOMe
• Psychedelics
• Phenethylamines