Revision as of 18:09, 23 February 2014

Psilocetin (4-AcO-DMT)
The skeletal formula of Psilocetin (4-AcO-DMT).
Dosage
Threshold	5 - 10mg
Light	10 - 20mg
Common	20 - 30mg
Strong	30 - 40mg
Heavy	40mg +
Duration
Total Duration	6 - 8 hours
Onset	20 - 60 minutes
Initial effects	15 - 30 minutes
Peak	3 - 6 hours
Coming down	3 - 5 hours
After effects	2 - 5 hours

Psilocetin (also known as O-Acetylpsilocin, 4-Acetoxy-DMT, or 4-AcO-DMT) is a synthetically produced psychoactive drug and has been suggested by David Nichols to be a potentially useful alternative to psilocybin for pharmacological studies, as they are both believed to be prodrugs of psilocin. However, many report that psilocetin's effects differ greatly from that of psilocybin and psilocin.

Chemistry

Skeletal formula of psilocetin molecule.

Psilocetin is made up of a tryptamine backbone with an acetoxy group attached to carbon R₄ of the indole ring, and two methyl groups substituted onto the nitrogen R_N1 and R_N2.

Pharmacology

Psilocetin acts as a 5-HT_2A, 5-HT_2C and 5-HT_1A partial agonist; the psychedelic effects are believed to come from psilocetin's efficacy at the 5-HT_2A receptors. At high doses, there is some efficacy to noradrenaline receptors.

Subjective effects

Physical effects

The physical effects of Psilocetin can be broken down into five components all of which progressively intensify proportional to dosage.

Spontaneous tactile sensations - the body high of Psilocetin can be described as a pleasurable, warm, soft and all encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
Sedation - in terms of its effects on the physical energy levels of the tripper Psilocetin is considered by most to be relaxing, stoning and mildly sedating. This sense of sedation is accompanied by compulsive yawning, a runny nose and watering eyes.

Cognitive effects

The head space of Psilocetin is described by many as extremely relaxing, profound and stoning in its style when compared to other commonly used psychedelics such as LSD or 2C-B which tend to be energetic and stimulating. It contains a large number of psychedelic typical and unique cognitive effects.

The most prominent of these typical effects include:

Introspection
Connectivity of thought
Outrospection - can be described as states of contemplation which feel almost forcibly directed towards contemplating the society we live in, the nature of existence, our place in the universe and other general philosophical thoughts.
Enhancement of current mind state
Removal of cultural filter
Feelings of fascination, importance and awe
Conceptual thinking
Direct communication with the subconscious
Ego suppression, loss and death
Time distortion
Deja-vu
States of unity and interconnectedness

The most commonly reported unique cognitive effects include:

Cognitive enhancement and suppression cycles - Can be described as constant waves of extremely stimulated and profound thinking which are spontaneously surpassed cyclic by waves of general thought suppression and mental intoxication. These two states seem to switch between each other in a consistent loop once every 20 - 60 minutes.

Visual effects

Enhancements

Psilocetin presents a full and complete array of possible visual enhancements which generally includes:

Distortions

As for visual distortions and alterations, effects experienced are detailed below:

Drifting (Melting, Flowing, Breathing and morphing) - in comparison to other psychedelics this effect can be described as highly detailed, slow and smooth in motion and static in their appearance.
Tracers
After images
Texture repetition
Colour shifting
Scenery slicing

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT, Ayahuasca and 2C-E than LSD. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, blurred in their edges and rounded in their corners. They have a very "natural" feel to them and at higher dosages are significantly more likely to result in states of Level 7B visual geometry over Level 7A.

Hallucinatory states

Psilocetin and its various other forms produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. These effects include:

Imagery - in comparison to other psychedelics such as LSD, Psilocetin is extremely high in imagery embedded within visual geometry.
Transformations
Breakthroughs - this particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.

Auditory effects

The auditory effects of Psilocetin are common in their occurrence and exhibit a full range of effects which commonly includes:

Toxicity and Harm Potential

Lethal Dosage

The LD₅₀ of psilocetin has been extrapolated from animal results to 800mg for an average human.

Tolerance and Addiction Potential

Psilocetin tolerance lasts for approximately a week, meaning that it is very difficult to form an addiction to this substance. It also has a high cross-tolerance, affecting the potency of other tryptamines.

Legal Issues

Possession and sale of psilocetin is unscheduled in most countries.

UK: Could be considered illegal under the 1971 Misuse of Drugs Act as it metabolises into psilocin.
USA: Could be considered illegal under the Federal Analog Act as an analogue of psilocin.

@@ Line 1: / Line 1: @@
 {| class="wikitable" align="right"
-! colspan="2" style="background:lightblue;width:200px;font-size:10pt" | Psilacetin (4-AcO-DMT)
+! colspan="2" style="background:lightblue;width:200px;font-size:10pt" | Psilocetin (4-AcO-DMT)
 |-
-| colspan="2" style="text-align:center;font-size:7pt" | [[Image:Psilocetin.png|noframe|243px]]<br />The skeletal formula of Psilacetin (4-AcO-DMT).
+| colspan="2" style="text-align:center;font-size:7pt" | [[Image:Psilocetin.png|noframe|243px]]<br />The skeletal formula of Psilocetin (4-AcO-DMT).
 |-
 | colspan="2" style="background:lightblue;text-align:center;font-size:9pt" | '''Dosage'''
@@ Line 14: / Line 14: @@
 | style="font-size:9pt" | Strong || style="font-size:9pt" | 30 - 40mg
 |-
-| style="font-size:9pt" | Breakthrough threshold || style="font-size:9pt" | 100mg +
+| style="font-size:9pt" | Heavy || style="font-size:9pt" | 40mg +
 |-
-| style="font-size:9pt" | Breakthrough|| style="font-size:9pt" | 120mg+
+| colspan="2" style="background:lightblue;text-align:center;font-size:9pt" | '''Duration'''
 |-
-| style="font-size:9pt" | Highest reported dose || style="font-size:9pt" | 250mg
+| style="font-size:9pt" | Total Duration|| style="font-size:9pt" | 6 - 8 hours
 |-
-| colspan="2" style="background:lightblue;text-align:center;font-size:9pt" | '''Duration'''
+| style="font-size:9pt" | Onset|| style="font-size:9pt" | 20 - 60 minutes
 |-
-| style="font-size:9pt" | Total Duration|| style="font-size:9pt" | 3 - 5 hours
+| style="font-size:9pt" | Initial effects|| style="font-size:9pt" | 15 - 30 minutes
 |-
-| style="font-size:9pt" | Onset|| style="font-size:9pt" | 10-20 min (insufflated)
+| style="font-size:9pt" | Peak|| style="font-size:9pt" | 3 - 6 hours
 |-
-| style="font-size:9pt" | Onset|| style="font-size:9pt" | 40 - 60 minutes (oral)
+| style="font-size:9pt" | Coming down|| style="font-size:9pt" | 3 - 5 hours
 |-
-| style="font-size:9pt" | Peak|| style="font-size:9pt" | 30 minutes
+| style="font-size:9pt" | After effects|| style="font-size:9pt" | 2 - 5 hours
 |}
-'''Psilacetin''' (also '''O-Acetylpsilocin''', '''4-Acetoxy-DMT''', or '''4-AcO-DMT'''), a synthetically produced psychoactive tryptamine suggested by David Nichols to be a potentially useful alternative to [[Psilocin#Chemistry|psilocybin]] for pharmacological studies.
+'''Psilocetin''' (also known as '''O-Acetylpsilocin''', '''4-Acetoxy-DMT''', or '''4-AcO-DMT''') is a synthetically produced psychoactive drug and has been suggested by David Nichols to be a potentially useful alternative to [[Psilocin#Chemistry|psilocybin]] for pharmacological studies, as they are both believed to be prodrugs of [[psilocin]]. However, many report that psilocetin's effects differ greatly from that of psilocybin and psilocin.
 =Chemistry=
 [[File:Tryptamine_rests.png|thumb|255px|right|General formula of a tryptamine molecule.]]
-[[File:Psilocetin.png|thumb|255px|right|Skeletal form of psilacetin molecule.]]
+[[File:Psilocetin.png|thumb|255px|right|Skeletal formula of psilocetin molecule.]]
-Psilacetin is made up of a tryptamine backbone with an acetoxy (acetyl) group attached to carbon R<sub>4</sub> of the indole ring, and two methyl groups substituted onto the nitrogen R<sub>N1</sub> and R<sub>N2</sub>.
+Psilocetin is made up of a tryptamine backbone with an acetoxy group attached to carbon R<sub>4</sub> of the indole ring, and two methyl groups substituted onto the nitrogen R<sub>N1</sub> and R<sub>N2</sub>.
 =Pharmacology=
-Psilacetin acts as a 5-HT<sub>2A</sub>, 5-HT<sub>2C</sub> and 5-HT<sub>1A</sub> [[Agonist#Agonists|partial agonist]]; the psychedelic effects are believed to come from psilacetin's efficacy at the 5-HT<sub>2A</sub> receptors. At high doses, there is some efficacy to noradrenaline receptors.
+Psilocetin acts as a 5-HT<sub>2A</sub>, 5-HT<sub>2C</sub> and 5-HT<sub>1A</sub> [[Agonist#Agonists|partial agonist]]; the psychedelic effects are believed to come from psilocetin's efficacy at the 5-HT<sub>2A</sub> receptors. At high doses, there is some efficacy to noradrenaline receptors.
-It is observed to shift cellular metabolic processes from those which rely on the deacetylace enzyme, an important enzyme in catabolic reactions, to other processes for generating energy. The substantiative observable physical effect is the feeling of cold at the cellular level, as if heat has not been produced as it normally is and metabolism has shifted en mass to anabolic or other processes. The perception of these gaps of heat is (relatively speaking) quantitized and feels subjectively like holes in a lattice. This sense is most noticable in cartilige rich tissue subject to cooling effects of breathing (i.e. the nose)
-==[[Physical effects]]==
-The physical effects of Psilacetin are most notably attributed to its metabolic route, the deacetylase enzyme in part. This enzyme is responsible for catabolic energy generation processes at a cellular level (see:mitochondria). At doses between 100 and 250 mg it becomes noticable that the body quantitizes heat as energy as part of ongoing processes which sustain life. This heat must be produced by other means, and shivering is quite common during exposure to cold temperatures.
 =Subjective effects=
-"i projected my thoughts and watched others do the same. Their projections appeared encrypted to me."
+==[[Physical effects - Psychedelics|Physical effects]]==
+The physical effects of Psilocetin can be broken down into five components all of which progressively intensify proportional to dosage.
-At high doses its apparent that thought is projected quite easily into space by the minds eye. These thought projections are theorized to be illuminated by the fluorescence of the tryptamines. By resonating with the frequencies accompanying the visual space is it appears in bright focus as a separate reality, a fluorescing projection. The usefulness of this is attenuating to silence. The smallest sound within the body is perceptable, even if it is not audible, and the lattice vibration induced by the sudden shift is one such such inaudible sound.
+*'''[[Physical effects: Spontaneous tactile sensations|Spontaneous tactile sensations]]''' - the body high of Psilocetin can be described as a pleasurable, warm, soft and all encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
+*'''[[Physical effects: Sedation|Sedation]]''' - in terms of its effects on the physical energy levels of the tripper Psilocetin is considered by most to be relaxing, stoning and mildly sedating. This sense of sedation is accompanied by compulsive yawning, a runny nose and watering eyes.
-There was also a shared experiency by multiple observers of being admitted by an entity into several different simulations.
-*'''[[Physical effects: Spontaneous tactile sensations|Spontaneous tactile sensations]]''' - the body high of Psilacetin can be described as a pleasurable, warm, soft and all encompassing tingling sensation. At high doses this sensation can correspond to feedback produced from a simulation.
-*'''[[Physical effects: Sedation|Sedation]]''' - in terms of effects on the physical energy levels Psilacetin is considered relaxing, yin, and mildly sedating. These sensations may be accompanied by compulsive yawning, a runny nose and watering eyes.
 ==[[Cognitive effects - Psychedelics|Cognitive effects]]==
-It's described by many as extremely relaxing and immersingly visual (in breakthrough) compared to other commonly used psychedelics such as [[LSD]] or [[2C-B]] which tend to be energetic and stimulating. It contains a large number of psychedelic typical and unique cognitive effects.
+The head space of Psilocetin is described by many as extremely relaxing, profound and stoning in its style when compared to other commonly used psychedelics such as [[LSD]] or [[2C-B]] which tend to be energetic and stimulating. It contains a large number of psychedelic typical and unique cognitive effects.
 The most prominent of these typical effects include:
@@ Line 65: / Line 56: @@
 *'''[[Cognitive effects: Introspection|Introspection]]'''
 *'''[[Cognitive effects: Connectivity of thought|Connectivity of thought]]'''
-*'''[[Cognitive effects: Outrospection|Outrospection]]'''
+*'''[[Cognitive effects: Outrospection|Outrospection]]''' -  can be described as states of contemplation which feel almost forcibly directed towards contemplating the society we live in, the nature of existence, our place in the universe and other general philosophical thoughts.
-*'''[[Cognitive effects: Emotion|Emotion]]'''
+*'''[[Cognitive effects: Enhancement of current mind state|Enhancement of current mind state]]'''
+*'''[[Cognitive effects: Removal of cultural filter|Removal of cultural filter]]'''
 *'''[[Cognitive effects: Feelings of fascination, importance and awe|Feelings of fascination, importance and awe]]'''
 *'''[[Cognitive effects: Conceptual thinking|Conceptual thinking]]'''
 *'''[[Cognitive effects: Direct communication with the subconscious|Direct communication with the subconscious]]'''
-*'''[[Cognitive effects: Entitiy Contact|Entity Contact]]'''
+*'''[[Cognitive effects: Ego suppression, loss and death|Ego suppression, loss and death]]'''
-*'''[[Cognitive effects: Ego suppression, loss and death|Ego death]]'''
 *'''[[Cognitive effects: Time distortion|Time distortion]]'''
 *'''[[Cognitive effects: Deja-Vu|Deja-vu]]'''
-*'''[[Cognitive effects: Unity consciousness|Unity consciousness]]'''
+*'''[[Cognitive effects: States of unity and interconnectedness|States of unity and interconnectedness]]'''
 The most commonly reported unique cognitive effects include:
 *'''Cognitive enhancement and suppression cycles''' - Can be described as constant waves of extremely stimulated and profound thinking which are spontaneously surpassed cyclic by waves of general thought suppression and mental intoxication. These two states seem to switch between each other in a consistent loop once every 20 - 60 minutes.
-*'''breakthrough: encryption in perceptual artifacts''' - A common theme is the perception of (seemingly infinite) indexies. Some of the imagery seemed, subjectively, to contain artifacts of encryption. Perhaps this is merely a function of the speed of the trip at peak and not having time to put all the visual information into words. The visual part is immersing such that the soundtrack/auditory component incorporates the visual data, leaving a lot implied/assumed. The peak visuals in breakthrough seem as though they do not occur linealy in time, as in extreme time dialation (inception). Afterwards, the memories are consolidated, the brain isn't expecting to get hours of immersing sense data in minutes so most of it ends up as diseparate lacking the grain of expressability which came with continuity of abstract visual metaphors. Without (quickly) putting the important visual aspects into words one is left with very little of value except the inexpressable truth which has been recieved. Most noted at high (200+mg) doses.
-The entity which admits one to the simulations did not communicate with us. Admittedly it was a pretty sketchy amusement park.
 ==[[Visual effects - Psychedelics|Visual effects]]==
 ===[[Visual effects - Psychedelics#Enhancements|Enhancements]]===
-Psilacetin presents a full and complete array of possible visual enhancements which generally includes:
+Psilocetin presents a full and complete array of possible visual enhancements which generally includes:
 *'''[[Visual effects: Increased visual acuity|Increased visual acuity]]'''
-*'''[[Visual effects: Fluorescent Colors|Fluorescent Colors]]'''
+*'''[[Visual effects: Enhancement of colour|Enhancement of colour]]'''
-*'''[[Visual effects: Pattern recognition|Pattern recognition]]'''
+*'''[[Visual effects: Enhanced pattern recognition|Enhanced pattern recognition]]'''
-*'''[[Visual effects: Thought projection|Thought projection]]'''
 ===[[Visual effects - Psychedelics#Distortions|Distortions]]===
@@ Line 103: / Line 89: @@
 ===[[Visual effects - Psychedelics#Geometry|Geometry]]===
 The visual geometry that is present throughout this trip can be described as more similar in appearance to that of [[Psilocetin|4-AcO-DMT]], [[Ayahuasca]] and [[2C-E]] than [[LSD]]. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, blurred in their edges and rounded in their corners. They have a very "natural" feel to them and at higher dosages are significantly more likely to result in states of [[Visual effects - Psychedelics#7B - Exposure to inner mechanics of human consciousness|Level 7B]] visual geometry over [[Visual effects - Psychedelics#7A - Exposure to entirety of neurological structure|Level 7A]].
+===[[Visual effects - Psychedelics#Hallucinatory States|Hallucinatory states]]===
+Psilocetin and its various other forms produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. These effects include:
+*'''[[Visual effects: Imagery (psychedelic)|Imagery]]''' - in comparison to other psychedelics such as [[LSD]], Psilocetin is extremely high in imagery embedded within visual geometry.
+*'''[[Visual effects: Transformations (psychedelic)|Transformations]]'''
+*'''[[Visual effects: Breakthroughs (psychedelic)|Breakthroughs]]''' - this particular effect commonly contains hallucinations with [[Visual effects - Psychedelics#Scenarios and plots|scenarios]], [[Visual effects - Psychedelics#Landscapes, sceneries and settings|settings]], [[Visual effects - Psychedelics#Concepts|concepts]] and [[Visual effects - Psychedelics#Autonomous entities|autonomous entity]] contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.
 ===[[Auditory effects - Psychedelics|Auditory effects]]===
-The auditory effects of Psilacetin are common in their occurrence and exhibit a full range of effects which commonly includes:
+The auditory effects of Psilocetin are common in their occurrence and exhibit a full range of effects which commonly includes:
 *'''[[Auditory effects: Enhancements|Enhancements]]'''
 *'''[[Auditory effects: Distortions|Distortions]]'''
@@ Line 111: / Line 103: @@
 =Toxicity and Harm Potential=
-==Danger Potential==
-The danger of psilacetin stems from its being metabolized in part by the deacetylase enzyme. This enzyme is used by the body in catabolic reactions at a cellular level. High doses (100-250mg) suspend this process for a time, by competeing for the enzyme. This can make one extremely sensitive to cold. It is possible to reach a staate of hypothermia quite easily at high doses and the lethality is likely attributable this acute effect.
 ==Lethal Dosage==
-The LD<sub>50</sub> of psilacetin has been extrapolated from animal results to 800mg for an average human.
+The LD<sub>50</sub> of psilocetin has been extrapolated from animal results to 800mg for an average human.
-One may safely assume the lethal dose of psilacetin is 450-500mg. Above 300mg is excessive for most purposes.
 ==Tolerance and Addiction Potential==
-Psilacetin does not exhibit the same tolerance as other tryptamines. The deacetylace enzyme is used extensively for the aforementioned cellular processes related to heat generation. These reactions are highly regulated and directly affected by this compound in such a way that a tolerance is not possible. This opinion is shared by experienced users.
+Psilocetin tolerance lasts for approximately a week, meaning that it is very difficult to form an addiction to this substance. It also has a high cross-tolerance, affecting the potency of other tryptamines.
 =Legal Issues=
-Possession and sale of psilacetin is unscheduled in most countries.
+Possession and sale of psilocetin is unscheduled in most countries.
 *'''UK:''' Could be considered illegal under the 1971 Misuse of Drugs Act as it metabolises into [[psilocin]].
 *'''USA:''' Could be considered illegal under the Federal Analog Act as an analogue of psilocin.

4-AcO-DMT: Difference between revisions

Revision as of 18:09, 23 February 2014

Contents

Chemistry

Pharmacology

Subjective effects

Physical effects

Cognitive effects

Visual effects

Enhancements

Distortions

Geometry

Hallucinatory states

Auditory effects

Toxicity and Harm Potential

Lethal Dosage

Tolerance and Addiction Potential

Legal Issues

See Also

Navigation menu

4-AcO-DMT: Difference between revisions

Revision as of 18:09, 23 February 2014

Chemistry

Pharmacology

Subjective effects

Toxicity and Harm Potential

Lethal Dosage

Tolerance and Addiction Potential

Legal Issues

See Also

Navigation menu

Search