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Dextrorphan (DXO) is the pro-drug for [[Dextromethorphan]]. This means that it is metabolized in the body from DXM to form DXO, both of which are active chemicals which contribute towards the experience of subjective effects. The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an [[NMDA receptor antagonist]] as well as essentially inactive as a [[serotonin]] [[reuptake inhibitor]].<ref>Psychotropic Effects of Dextromethorphan Are Altered by the CYP2D6 Polymorphism: A Pilot Study [http://journals.lww.com/psychopharmacology/pages/articleviewer.aspx?year=1998&issue=08000&article=00014&type=abstract]</ref> | Dextrorphan (DXO) is the pro-drug for [[Dextromethorphan]]. This means that it is metabolized in the body from DXM to form DXO, both of which are active chemicals which contribute towards the experience of subjective effects. The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an [[NMDA receptor antagonist]] as well as essentially inactive as a [[serotonin]] [[reuptake inhibitor]].<ref>Psychotropic Effects of Dextromethorphan Are Altered by the CYP2D6 Polymorphism: A Pilot Study [http://journals.lww.com/psychopharmacology/pages/articleviewer.aspx?year=1998&issue=08000&article=00014&type=abstract]</ref> | ||
==See | ==See also== | ||
*[[Dextromethorphan]] | *[[Dextromethorphan]] | ||
Revision as of 17:18, 18 January 2015
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This article is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it. |
Dextrorphan (DXO) is the pro-drug for Dextromethorphan. This means that it is metabolized in the body from DXM to form DXO, both of which are active chemicals which contribute towards the experience of subjective effects. The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an NMDA receptor antagonist as well as essentially inactive as a serotonin reuptake inhibitor.[1]