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Template:Warning/Nicotine: Difference between revisions
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| <div class="icon">[[File:Yellow-warning-sign1.svg|50px|link=]]</div> || <p class="title"><span style="color:#8B8000">'''The nicotine metabolite N-nitrosonornicotine is classified as a IARC Group 1 carcinogen'''</span></p> | | <div class="icon">[[File:Yellow-warning-sign1.svg|50px|link=]]</div> || <p class="title"><span style="color:#8B8000">'''The nicotine metabolite N-nitrosonornicotine is classified as a IARC Group 1 carcinogen'''</span></p> | ||
Nicotine in the mouth and stomach can react to form N-nitrosonornicotine (NNN),<ref name=":1">{{cite journal | vauthors = Knezevich A, Muzic J, Hatsukami DK, Hecht SS, Stepanov I | title = Nornicotine nitrosation in saliva and its relation to endogenous synthesis of N'-nitrosonornicotine in humans | journal = Nicotine & Tobacco Research | volume = 15 | issue = 2 | pages = 591–5 | date = February 2013 | pmid = 22923602 | pmc = 3611998 | doi = 10.1093/ntr/nts172 }}</ref> a known type 1 carcinogen,<ref name=":2">{{cite web|title=List of Classifications – IARC Monographs on the Identification of Carcinogenic Hazards to Humans|url=https://monographs.iarc.fr/list-of-classifications|access-date=2020-07-22|website=monographs.iarc.fr}}</ref> suggesting that consumption of non-tobacco forms of nicotine may still play a role in carcinogenesis.<ref>{{cite journal | vauthors = Sanner T, Grimsrud TK | title = Nicotine: Carcinogenicity and Effects on Response to Cancer Treatment - A Review | journal = Frontiers in Oncology | volume = 5 | pages = 196 | date = 2015-08-31 | pmid = 26380225 | pmc = 4553893 | doi = 10.3389/fonc.2015.00196 | doi-access = free }}</ref> This suggests that even oral nicotine replacement therapy products could theoretically contribute to cancer risk | Nicotine in the mouth and stomach can react to form N-nitrosonornicotine (NNN),<ref name=":1">{{cite journal | vauthors = Knezevich A, Muzic J, Hatsukami DK, Hecht SS, Stepanov I | title = Nornicotine nitrosation in saliva and its relation to endogenous synthesis of N'-nitrosonornicotine in humans | journal = Nicotine & Tobacco Research | volume = 15 | issue = 2 | pages = 591–5 | date = February 2013 | pmid = 22923602 | pmc = 3611998 | doi = 10.1093/ntr/nts172 }}</ref> a known type 1 carcinogen,<ref name=":2">{{cite web|title=List of Classifications – IARC Monographs on the Identification of Carcinogenic Hazards to Humans|url=https://monographs.iarc.fr/list-of-classifications|access-date=2020-07-22|website=monographs.iarc.fr}}</ref> suggesting that consumption of non-tobacco forms of nicotine may still play a role in carcinogenesis.<ref>{{cite journal | vauthors = Sanner T, Grimsrud TK | title = Nicotine: Carcinogenicity and Effects on Response to Cancer Treatment - A Review | journal = Frontiers in Oncology | volume = 5 | pages = 196 | date = 2015-08-31 | pmid = 26380225 | pmc = 4553893 | doi = 10.3389/fonc.2015.00196 | doi-access = free }}</ref> This suggests that even oral nicotine replacement therapy products could theoretically contribute to cancer risk. | ||
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'''To stay safer:''' Nicotine patches used as directed do not pose this risk, since NNN formation does not occur through absorption via the skin. | '''To stay safer:''' Nicotine patches used as directed do not pose this risk, since NNN formation does not occur through absorption via the skin. | ||
Latest revision as of 17:05, 4 July 2025
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The nicotine metabolite N-nitrosonornicotine is classified as a IARC Group 1 carcinogen Nicotine in the mouth and stomach can react to form N-nitrosonornicotine (NNN),[1] a known type 1 carcinogen,[2] suggesting that consumption of non-tobacco forms of nicotine may still play a role in carcinogenesis.[3] This suggests that even oral nicotine replacement therapy products could theoretically contribute to cancer risk. To stay safer: Nicotine patches used as directed do not pose this risk, since NNN formation does not occur through absorption via the skin. |
- ↑ Knezevich A, Muzic J, Hatsukami DK, Hecht SS, Stepanov I (February 2013). "Nornicotine nitrosation in saliva and its relation to endogenous synthesis of N'-nitrosonornicotine in humans". Nicotine & Tobacco Research. 15 (2): 591–5. doi:10.1093/ntr/nts172. PMC 3611998
. PMID 22923602.
- ↑ "List of Classifications – IARC Monographs on the Identification of Carcinogenic Hazards to Humans". monographs.iarc.fr. Retrieved 2020-07-22.
- ↑ Sanner T, Grimsrud TK (2015-08-31). "Nicotine: Carcinogenicity and Effects on Response to Cancer Treatment - A Review". Frontiers in Oncology. 5: 196. doi:10.3389/fonc.2015.00196 . PMC 4553893 . PMID 26380225.