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Template:SubstanceBox/Datura: Difference between revisions

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>MountainTraveler
Data and numbers have been off for a while. Preface needed more detail.
>Blackhole
m Reverted edits by MountainTraveler (talk) to last revision by Isaak
 
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     <!-- Modules -->
     <!-- Modules -->
     |ModuleSource=true
     |ModuleSource=true
     |ModuleCombination=false  
     |ModuleCombination=false
     |ModuleStructure=false
     |ModuleStructure=false
     |ModuleNomenclature=true
     |ModuleNomenclature=true
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     |PhotoImageFile=File:Datura_inoxia.jpg
     |PhotoImageFile=File:Datura_inoxia.jpg
     |PhotoImageWidth=220px
     |PhotoImageWidth=220px
     |PhotoImageCaption= Illustration of ''D. stramonium''
     |PhotoImageCaption=Drawing of D. stramonium


     <!-- Combination -->
     <!-- Combination -->
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     <!-- Nomenclature -->
     <!-- Nomenclature -->
     |NameCommon=[[common name::Datura]], [[common name::Jimsonweed]] ''or'' [[common name::Jimson Weed]], [[common name::Jamestown Weed]], [[common name::Devil’s snare]], [[common name::Toloache (tribal name)]], [[common name::Momoy (tribal name)]]
     |NameCommon=[[common name::Datura]], [[common name::Jimson Weed]]
     |NameSubstitution=Angel's Trumpet (''dated''), Devil’s Trumpet, Devil's Apple, Thorn Apple, Sacred Datura, Stinkweed, Indian Whiskey, “Ghost-busters” (''Navajo'' term) Devil's Weed, Moonflower, Zombi Cucumber (''Haitian'' term), Tlapatl, Mixitl
     |NameSubstitution=Angel's Trumpets, Devil's Apple, Thorn Apple, Stinkweed, Devil's Weed, Moonflower
     |NameSystematic=
     |NameSystematic=


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     |EffectClass=[[Deliriant]]
     |EffectClass=[[Deliriant]]
     |ChemicalClass=[[Tropane alkaloid]]
     |ChemicalClass=[[Tropane alkaloid]]
    |PharmacologicalClass= M1 receptors, a neural sub-site of the muscarinic acetylcholine receptors. Particularly those present throughout the central nervous system and brain.


     <!-- Dosage/Duration -->
     <!-- Dosage/Duration -->


     |SmokedROA=true
     |SmokedROA=false
     |SmokedROA_Collapsed=true
     |SmokedROA_Collapsed=true
     |SmokedROA_Caption=
     |SmokedROA_Caption=
     |SmokedROA_Bioavailability=
     |SmokedROA_Bioavailability=
     |SmokedROA_Threshold=< N/A mg
     |SmokedROA_Threshold=< x mg
     |SmokedROA_Light= N/A mg
     |SmokedROA_Light=x - x mg
     |SmokedROA_Common= N/A mg
     |SmokedROA_Common=x - x mg
     |SmokedROA_Strong= N/A mg
     |SmokedROA_Strong=x - x mg
     |SmokedROA_Heavy=> N/A mg
     |SmokedROA_Heavy=> x  mg
     |SmokedROA_TimelineFile=
     |SmokedROA_TimelineFile=
     |SmokedROA_TimelineWidth=
     |SmokedROA_TimelineWidth=
     |SmokedROA_Duration= N/A minutes
     |SmokedROA_Duration=x minutes
     |SmokedROA_Onset= 4 - 6 minutes
     |SmokedROA_Onset=x seconds
     |SmokedROA_Peak=2 - 4 hours
     |SmokedROA_Peak=x minutes
     |SmokedROA_Offset=N/A hours
     |SmokedROA_Offset=x hours
     |SmokedROA_Aftereffects=Several days to weeks
     |SmokedROA_Aftereffects=x hours


     |OralROA=true
     |OralROA=true
     |OralROA_Collapsed=false
     |OralROA_Collapsed=false
     |OralROA_Caption= Oral administration is usually the most common ROA. But many users or new experimenters tend to heuristically presume that oral administration is the only way to facilitate its proper effects. On the other hand though, ''Scopolamine'' also possesses the property of transdermal bioavailability to elicit effects since the alkaloid scopolamine can adequately absorb through the skin. Additionally, although still somewhat controversial, there are reports of “success” just from smoking the plant as well where it has been consistently reported to kick-in after only a few minutes through combustion and inhalation. Smoking of daturas has alas become an evermore common factor in “accidental” poisonings largely due to users not expecting such anticholinergic feelings and symptoms by this method.
     |OralROA_Caption=
<br>''' There is no “set” or predictable dosage amount that can be realistically  quantified or even “averaged out” to for ''Datura''; or any of the other antimuscarinic nightshades since alkaloid levels and the chemical compositions/ratios differ wildly between Datura plants even of the same species or “variety” (sub-subspecies), often dramatically too. The supposed factors which influence these risky variables are mainly due to seasonal variations, weather/growing conditions, geographical proximity and ecological surroundings (such as nearby plants being locally competitive), physical age of the plant, level of shade, soil composition, level or degree of (UV) sunlight exposure, temperature, users’ own personal genetic traits, users’ relationship or reaction to other cholinergic drugs or supplements, the user’s age (elderly most at risk for senility, children most at risk for physical toxidrome and death), also the exact part(s) of the plant used, the method of administration, and the formal preparation it’s made into before administration (such as an aqueous solution/concoction, brew, topical ointment), etc. Traditionally, datura; along with the other classic tropane-rich nightshade hallucinogens; although the nightshade component itself already serves to sufficiently function as the main, integral and active ingredient in archaic magical witches’ brews, or in their magical ointments and salves; it was purportedly commonplace and even promoted by herbalists, ‘cunning folk’, seers, necromancers and other related niche (heretical) subcultures that a handful of other (often locally-sourced) plants, herbs, poisons and/or specimens would presumably synergize with the nightshade in a “ecologically harmonious” way by augmenting certain effects which were desired more desired, but with other, herbal or natural ingredients to counter the unpleasant or even unhealthy side effects. Some evidence suggest that certain neuroprotective plants and medicines were utilized either during, before or after the nightshade ritual or experience for some stint of time so as to prevent or even ''reverse'' early neurological sequela or avoid the prodromal indicators of future dementia and “madness”. A number of these presumed neuroprotective plants and medicines are even still being investigated in modern times using science, particularly pro-cholinergic agents such as cannabis, tea, (data on nicotine is too mixed or paradoxical), and Galantamine among others when it comes to studying the treatment or prevention of various dementias. One hypothesis is that endogenous neurotransmitter acetylcholine isn’t just a viral memory consolidation but may also protect the brain from aging in general. Prototypical and crude forms of these kinds of approaches were first figured out and put into practice almost exclusively by Western Europeans, and eventually colonialists along the eastern United States. Between the Late Medieval years and the colonial Early Modern timeframe in Western history, this is around when these kinds of multilayered, highly-developed methodologies for sacred plant use had reached its peak. Naturally, it soon became a negative stereotype and/or are you showcasing of poor taste just to have a ''Datura stramonium'' flower growing in your garden within New England during colonial times.
<br>'''The dosage differs wildly between plants.'''
 
     |OralROA_Bioavailability=
     |OralROA_Bioavailability=
     |OralROA_Threshold= N/A
     |OralROA_Threshold=
     |OralROA_Light= N/A
     |OralROA_Light=
     |OralROA_Common= N/A
     |OralROA_Common=
     |OralROA_Strong= N/A
     |OralROA_Strong=
     |OralROA_Heavy= N/A
     |OralROA_Heavy=
     |OralROA_TimelineFile=
     |OralROA_TimelineFile=
     |OralROA_TimelineWidth=
     |OralROA_TimelineWidth=
     |OralROA_Duration=7 - 50 hours (however experiences outlasting even a full 2 days is not uncommon)
     |OralROA_Duration=8 - 18 hours
     |OralROA_Onset=[[Oral min onset time::20]] - [[Oral max onset time::120]] [[Oral onset time units::minutes]]
     |OralROA_Onset=[[Oral min onset time::20]] - [[Oral max onset time::120]] [[Oral onset time units::minutes]]
     |OralROA_Comeup=[[Oral min comeup time::60]] - [[Oral max comeup time::120]] [[Oral comeup time units::minutes]]
     |OralROA_Comeup=[[Oral min comeup time::60]] - [[Oral max comeup time::120]] [[Oral comeup time units::minutes]]
     |OralROA_Peak=5 - 12 hours
     |OralROA_Peak=5 - 12 hours
     |OralROA_Offset=2 - 5 hours (its ''offset'' frequently imbibes a sense of vagueness often making it hard to decipher even subjectively if or when one has actually regained their ‘centering’ or sense of normalcy).
     |OralROA_Offset=2 - 3 hours
     |OralROA_Aftereffects=Days to weeks (usually 2 - 3 weeks at most granted ongoing residual effects outlasting a month or more are rare but still not unheard of)
     |OralROA_Aftereffects=6 - 24 hours


}}
}}

Latest revision as of 05:14, 2 June 2024

SubstanceBox/Datura
Drawing of D. stramonium
Chemical Nomenclature
Common names Datura, Jimson Weed
Substitutive name Angel's Trumpets, Devil's Apple, Thorn Apple, Stinkweed, Devil's Weed, Moonflower
Class Membership
Psychoactive class Deliriant
Chemical class Tropane alkaloid
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



⇣ Oral
Dosage
Duration
Total 8 - 18 hours
Onset 20 - 120 minutes
Come up 60 - 120 minutes
Peak 5 - 12 hours
Offset 2 - 3 hours
After effects 6 - 24 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

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