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DMXE, like the majority of dissociatives, belongs to the class of arylcyclohexylamines. It is derived from [[MXE]], having the methoxy residue replaced with a methyl residue <ref name="irie">Irie, T., Yanase, Y., Demizu, Y., Usami, M., & Kikura-Hanajiri, R. (2022). Derivatives of methoxetamine and major methoxetamine metabolites potently block NMDA receptors. In Journal of Pharmacological Sciences (Vol. 150, Issue 4, pp. 233–243). Elsevier BV. [https://doi.org/10.1016/j.jphs.2022.09.005]</ref>. DMXE's molecular formula therefore lacks an oxygen, which results in more hydrophobic and less bulky structure - causing the slight differences in pharmacology.
==Pharmacology==
==Pharmacology==
{{pharmacology}}
{{pharmacology}}
DMXE acts as an NMDA receptor antagonist. A specific subtype of glutamate receptor, NMDA (N-Methyl-D-Aspartate), modulates the transmission of electrical signals between neurons in the brain and spinal cord; for the signals to pass, the receptor must be open.
Dissociatives inhibit the normal functioning NMDA receptors by binding to and blocking them. This disruption of neural network activity leads to loss of normal cognitive and affective processing, psychomotor functioning, anesthesia and eventually the equivalent of a "k-hole".
An ''in silico'' study showed that DMXE binds to the same site of NMDARs as MXE and posseses comparable potency <ref name="irie" />
==Subjective effects==
==Subjective effects==
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*'''[[Effect::Stimulation]]'''
*'''[[Effect::Stimulation]]''' and '''[[Effect::Sedation]]''' - DMXE has been compared to MXE which is known for its especially sedating and relaxing effects. However dissociatives are also able to induce stimulation, usually in lower doses.
It may contain incorrect information, particularly with respect to dosage, duration, subjective effects, toxicity and other risks. It may also not meet PW style and grammar standards.
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
DMXE has been sold online since around October 2022, marketed as a legal replacement for MXE. [1]
Limited data exists about the pharmacological properties, metabolism, and toxicity of DMXE in humans, and it has a limited history of human use. It is highly advised to use harm reduction practices if using this substance.
DMXE, like the majority of dissociatives, belongs to the class of arylcyclohexylamines. It is derived from MXE, having the methoxy residue replaced with a methyl residue [2]. DMXE's molecular formula therefore lacks an oxygen, which results in more hydrophobic and less bulky structure - causing the slight differences in pharmacology.
DMXE acts as an NMDA receptor antagonist. A specific subtype of glutamate receptor, NMDA (N-Methyl-D-Aspartate), modulates the transmission of electrical signals between neurons in the brain and spinal cord; for the signals to pass, the receptor must be open.
Dissociatives inhibit the normal functioning NMDA receptors by binding to and blocking them. This disruption of neural network activity leads to loss of normal cognitive and affective processing, psychomotor functioning, anesthesia and eventually the equivalent of a "k-hole".
An in silico study showed that DMXE binds to the same site of NMDARs as MXE and posseses comparable potency [2]
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
Stimulation and Sedation - DMXE has been compared to MXE which is known for its especially sedating and relaxing effects. However dissociatives are also able to induce stimulation, usually in lower doses.
The toxicity and long-term health effects of recreational DMXE use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown.
This is because DMXE is a research chemical with a very brief history of human usage.
Warning:Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
↑ 2.02.1Irie, T., Yanase, Y., Demizu, Y., Usami, M., & Kikura-Hanajiri, R. (2022). Derivatives of methoxetamine and major methoxetamine metabolites potently block NMDA receptors. In Journal of Pharmacological Sciences (Vol. 150, Issue 4, pp. 233–243). Elsevier BV. [1]
