This is an unofficial archive of PsychonautWiki as of 2025-08-11T15:14:44Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
Is there any kind of scientifically published research about this substance? At least some dosage advice would be beneficial for potential users in terms of harm reductions. Anecdotal reports indicate this substances is pretty close the banned MXE in terms of effects and additionally it is organic skeletal formula. Is there any connections to the original creators or the documents they create?
{{headerpanel|{{Approval}}}}
{{Distinguish|Deoxymethoxetamine}}
{{SummarySheet}}
{{SubstanceBox/Deoxymethoxetamine}}
'''Deoxymethoxetamine''' (also known as '''DMXE''') is a [[psychoactive class::dissociative]] substance of the [[Chemical class::arylcyclohexylamine]] class that produces [[ketamine|ketamine-like]] [[dissociative]] effects when [[administered]].
DMXE has been sold online since around October 2022, marketed as a legal replacement for MXE. <ref>Alert from NDEWS Web Monitoring team: Increases in Reddit discussions of DMXE, October 2020–March 2021 | https://ndews.org/?wysija-page=1&controller=email&action=view&email_id=125&wysijap=subscriptions</ref>
--Wikipedia has some sources they list about availability:
Limited data exists about the pharmacological properties, metabolism, and toxicity of DMXE in humans, and it has a limited history of human use. It is highly advised to use [[harm reduction practices]] if using this substance.
It has been sold online since around October 2020, and was first definitively identified by a forensic laboratory in Denmark in February 2021.[1][2]
==History and culture==
{{historyStub}}
1. Alert from NDEWS Web Monitoring team: Increases in Reddit discussions of DMXE October 2020–March 2021". National Drug Early Warning System. University of Florida, funded by the National Institute on Drug Abuse (28). 26 March 2021.
==Chemistry==
{{chemistry}}
==Pharmacology==
{{pharmacology}}
2. Skinnider M, Wang F, Pasin D, Greiner R, Foster L, Dalsgaard P, Wishart DS (2021). "A Deep Generative Model Enables Automated Structure Elucidation of Novel Psychoactive Substances". ChemRxiv. Cambridge: Cambridge Open Engage
==Subjective effects==
{{EffectStub}}
{{Preamble/SubjectiveEffects}}
{{effects/base
|{{effects/physical|
*'''[[Effect::Stimulatio]]'''
*'''[[Effect::Pain relief]]'''
*'''[[Effect::Motor control loss]]'''
*'''[[Effect::Tactile suppression]]'''
}}
{{effects/disconnective|
*'''[[Effect::Tactile disconnection]]'''
*'''[[Effect::Visual disconnection]]''' - This eventually results in DMXE's equivalent of the "k-hole" or more specifically, ''[[Visual disconnection#Holes, spaces and voids|holes, spaces and voids]]'' alongside of ''[[Visual disconnection#Structures|structures]]''.
}}
{{effects/visual|
====Suppression====
*'''[[Effect::Visual acuity suppression]]'''
*'''[[Effect::Double vision]]'''
====Distortions====
*'''[[Effect::Perspective distortions]]'''
The title of this page should be Deoxymethoxetamine, all other known references to DMXE omit the 's' (though one would think conventional nomenclature should put it there). Can a chemist confirm de- and des- are both valid?
If applicable, a brief paragraph summary describing the visual geometry produced by the substance may be included here.
====Hallucinatory states====
If applicable, a brief summary of the substance's visual effects profile may be written here.
*'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'')
*'''[[Effect::External hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'')
General Dosage Guide (from HTTP://reddit.com/r/DMXE anecdotal evidence)
}}
'''Insufflated''':
|{{effects/cognitive|
Threshold 5-10mg
The general head space of DMXE, like MXE, is often described as particularly euphoric and clear-headed in comparison to that of [[DXM]] and [[ketamine]].
There are currently {{#ask:[[Category:DMXE]][[Category:Experience]] | format=count}} experience reports which describe the effects of this substance in our [[experience index]].
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}The toxicity and long-term health effects of recreational DMXE use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]].
This is because DMXE is a research chemical with a very brief history of human usage.
Common 15-25mg
It is strongly recommended that one use [[responsible use|harm reduction practices]] when using this substance.
It may contain incorrect information, particularly with respect to dosage, duration, subjective effects, toxicity and other risks. It may also not meet PW style and grammar standards.
DMXE has been sold online since around October 2022, marketed as a legal replacement for MXE. [1]
Limited data exists about the pharmacological properties, metabolism, and toxicity of DMXE in humans, and it has a limited history of human use. It is highly advised to use harm reduction practices if using this substance.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
The toxicity and long-term health effects of recreational DMXE use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown.
This is because DMXE is a research chemical with a very brief history of human usage.
Warning:Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
