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Unique substance warnings: Difference between revisions
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>David Hedlund Gathered unique substance warnings that I've collected (added to the linked pages) through the years. This should make it easy for Isaak to add warning messages to specific substances in PsychonautWiki Journal. |
>David Hedlund →Psychoactive substances: * DXM: "It should be noted that DXM in freebase form (as found in Robocough RoboTablets) is around 27-37% more potent than its hydrobromide form..." -- copy/pasted text from the DXM article |
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* [[MAOI]]s: Tyramine causes hypertensive crises after MAO inhibition aka the "cheese effect" or "cheese crisis". Using a MAO inhibitor (MAOI), the intake of approximately 10 to 25 mg of tyramine is required for a severe reaction compared to 6 to 10 mg for a mild reaction. Tyramine rich food should also be avoided by people prone to headache and migraine. Stilton (a blue cheese) contains up to 217 mg tyramine per 100 grams. - https://www.mc.vanderbilt.edu/documents/neurology/files/Tyramine%20Menu%20Book%2006227101.pdf | * [[MAOI]]s: Tyramine causes hypertensive crises after MAO inhibition aka the "cheese effect" or "cheese crisis". Using a MAO inhibitor (MAOI), the intake of approximately 10 to 25 mg of tyramine is required for a severe reaction compared to 6 to 10 mg for a mild reaction. Tyramine rich food should also be avoided by people prone to headache and migraine. Stilton (a blue cheese) contains up to 217 mg tyramine per 100 grams. - https://www.mc.vanderbilt.edu/documents/neurology/files/Tyramine%20Menu%20Book%2006227101.pdf | ||
* Psilocybin mushrooms: x mg psilocybin is stored in each fully developed fruit body. So the number of species is more relevant than the quantity. | * Psilocybin mushrooms: x mg psilocybin is stored in each fully developed fruit body. So the number of species is more relevant than the quantity. | ||
===Chemical forms=== | |||
* [[DXM]]: "It should be noted that DXM in freebase form (as found in Robocough RoboTablets) is around 27-37% more potent than its hydrobromide form due to a higher concentration of DXM by weight. One should take this into account when calculating their dose so as to avoid a potential overdose." | |||
===[[Dosage]]=== | ===[[Dosage]]=== | ||
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===Genotype=== | ===Genotype=== | ||
* [[THC]]: ''CYP2C9'' genotype affects THC sensitivity significantly: ''Subjects with the *3/*3 genotype had 3-fold higher THC levels in their blood than subjects with the *1/*1 genotype. Those subjects with one copy of each gene (*1/*3) had intermediate THC levels that were about 2-fold higher than subjects with *1/*1.''<ref>https://www.ncbi.nlm.nih.gov/books/NBK564166/</ref> | * [[THC]]: ''CYP2C9'' genotype affects THC sensitivity significantly: ''Subjects with the *3/*3 genotype had 3-fold higher THC levels in their blood than subjects with the *1/*1 genotype. Those subjects with one copy of each gene (*1/*3) had intermediate THC levels that were about 2-fold higher than subjects with *1/*1.''<ref>https://www.ncbi.nlm.nih.gov/books/NBK564166/</ref> | ||
==References== | ==References== | ||
{{reflist}} | {{reflist}} | ||
Revision as of 08:13, 7 February 2023
- Two-piece gel encapsulation ("hard capsules"): Dissolves fully within 10-60 minutes.
- Blotters: Orally administering (swallowing) substances whose identity is uncertain is a potential way to eliminate most of the effects from dangerous mimics like 25x-NBx (25x-NBOMe like 25I-NBOMe, and 25x-NBOH like 25I-NBOH, etc). 25I-NBOMe is widely rumored to be orally inactive; however, oral efficacy has not been disproven and apparent overdoses have occurred via oral administration. 25I-NBOMe (and other NB's like 25x-NBOMe, 25x-NBOH) has much lower oral bioavailability than sublingual, buccal, and sublabial administration. 25I-NBOMe, to which several deaths have been attributed.[1][2][3][4] may commonly be mistaken for LSD by sellers and users.[5]
Psychoactive substances
- MAOIs: Tyramine causes hypertensive crises after MAO inhibition aka the "cheese effect" or "cheese crisis". Using a MAO inhibitor (MAOI), the intake of approximately 10 to 25 mg of tyramine is required for a severe reaction compared to 6 to 10 mg for a mild reaction. Tyramine rich food should also be avoided by people prone to headache and migraine. Stilton (a blue cheese) contains up to 217 mg tyramine per 100 grams. - https://www.mc.vanderbilt.edu/documents/neurology/files/Tyramine%20Menu%20Book%2006227101.pdf
- Psilocybin mushrooms: x mg psilocybin is stored in each fully developed fruit body. So the number of species is more relevant than the quantity.
Chemical forms
- DXM: "It should be noted that DXM in freebase form (as found in Robocough RoboTablets) is around 27-37% more potent than its hydrobromide form due to a higher concentration of DXM by weight. One should take this into account when calculating their dose so as to avoid a potential overdose."
- 2C-P: 2C-P is known to have a steep dose-response curve, as little as a few extra milligrams separating a manageable dose and an overdose. Also, 2C-P can have a very slow onset if ingested, and peak effects reportedly do not occur for 3 to 5 hours.
- Codeine: Intravenous codeine can result in nonimmune mast-cell degranulation and resulting anaphylactoid reaction.
- Hydroxyzine: Intravenous formulations are unavailable due to a risk of hemolysis.
- Ketamine: Ketamine taken intravenously quicker than 1.5 minute can cause breathing depression for short time (up to a minute). - Ketamine: Dreams and Realities, p276
Genotype
- THC: CYP2C9 genotype affects THC sensitivity significantly: Subjects with the *3/*3 genotype had 3-fold higher THC levels in their blood than subjects with the *1/*1 genotype. Those subjects with one copy of each gene (*1/*3) had intermediate THC levels that were about 2-fold higher than subjects with *1/*1.[6]
References
- ↑ Erowid. "25I-NBOMe (2C-I-NBOMe) Fatalities / Deaths". Drug Website. Erowid. Retrieved February 28, 2016.
- ↑ Hastings, Deborah (May 6, 2013). "New drug N-bomb hits the street, terrifying parents, troubling cops". New York Daily News. Retrieved May 7, 2013.
- ↑ Feehan, Conor (January 21, 2016). "Powerful N-Bomb drug - responsible for spate of deaths internationally - responsible for hospitalisation of six in Cork". Irish Independent. Retrieved January 22, 2016.
- ↑ Iversen, Les (May 29, 2013). "Temporary Class Drug Order Report on 5-6APB and NBOMe compounds" (PDF). Advisory Council on the Misuse of Drugs. Gov.Uk. Retrieved June 16, 2013.
- ↑ Iversen, Les (May 29, 2013). "Temporary Class Drug Order Report on 5-6APB and NBOMe compounds" (PDF). Advisory Council on the Misuse of Drugs. Gov.Uk. p. 14. Retrieved June 16, 2013.
- ↑ https://www.ncbi.nlm.nih.gov/books/NBK564166/