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>Brack Psychoactive Substances that Mimic Psychiatric Disorders |
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=Psychoactive Substances that Mimic Psychiatric Disorders= | |||
==Dissociatives & Cannabis - Schizophrenia== | |||
{| class="wikitable" | |||
|+ Shared effects/phenotypes associated with dissociatives, marijuana, and schizophrenia | |||
|- | |||
! [[Dissociatives]] !! [[Cannabis]] !! Schizophrenia/Schizotypy | |||
|- | |||
| [[Personal meaning enhancement]] || [[Personal meaning enhancement]] || Positive symptoms of schizophrenia and schizotypy are associated with & thought to be caused by aberrant salience (the scientific term for personal meaning enhancement)<ref> The Aberrant Salience Inventory: A New Measure of Psychosis Proneness | https://psychology.unt.edu/sites/default/files/ASI.pdf</ref> | |||
|- | |||
| [[Paranoia]] || [[Paranoia]] || [[Paranoia]] considered to be diagnostic of schizophrenia spectrum disorders <ref>Schizotypal personality disorder: A current review | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182925/</ref> | |||
|- | |||
| [[Creativity enhancement]] || [[Creativity enhancement]] || A massive body of evidence shows a robust association with schizophrenia, schizotypy, and creativity <ref> Imagination in human social cognition, autism, and psychotic-affective conditions | https://www.sfu.ca/biology/faculty/crespi/pdfs/186-Cognition.pdf</ref> | |||
|- | |||
| [[Auditory hallucinations]] || [[Auditory hallucinations]] || [[Auditory hallucinations]] <ref> Psychosis and autism as diametrical | |||
disorders of the social brain | http://eprints.lse.ac.uk/21571/1/Psychosis%20and%20autism%20as%20diametrical%20disorders%20of%20the%20social%20brain%20(LSERO).pdf</ref> | |||
|- | |||
| [[Delusion]] || [[Delusion]] || [[Delusion]] <ref> Psychosis and autism as diametrical | |||
disorders of the social brain | http://eprints.lse.ac.uk/21571/1/Psychosis%20and%20autism%20as%20diametrical%20disorders%20of%20the%20social%20brain%20(LSERO).pdf</ref> | |||
|- | |||
| [[Auditory suppression|Auditory]] and [[Acuity suppression|visual]] suppression || [[Auditory suppression|Auditory]] and [[Acuity suppression|visual]] suppression || Schizophrenia associated with reduced sensory abilities <ref> Imagination in human social cognition, autism, and psychotic-affective conditions | https://www.sfu.ca/biology/faculty/crespi/pdfs/186-Cognition.pdf</ref> | |||
|- | |||
| [[Empathy, affection, and sociability enhancement|Empathy enhancement]] || [[Empathy, affection, and sociability enhancement|Empathy enhancement]] || Positive symptoms of schizophrenia and schizotypy associated with dysfunctionally increased cognitive empathy<ref> Psychosis and autism as diametrical disorders of the social brain | http://eprints.lse.ac.uk/21571/1/Psychosis%20and%20autism%20as%20diametrical%20disorders%20of%20the%20social%20brain%20(LSERO).pdf</ref> | |||
|- | |||
| [[Pain relief]] || [[Pain relief]] || Schizophrenia associated with reduced sensitivity to pain <ref> Decreased pain sensitivity among people with schizophrenia: a meta-analysis of experimental pain induction studies | https://gala.gre.ac.uk/id/eprint/15830/1/15830_Thompson_Decreased%20pain%20sensitivity%20%28AAM%29%202015.pdf</ref> | |||
|- | |||
| [[Depersonalization]] && [[Derealization]] || [[Depersonalization]] && [[Derealization]] || Dissociation & depersonalization associated with schizotypy & schizophrenia <ref>Dissociative Experiences in Hypothetically Psychosis-Prone College Students|https://www.empty-memories.nl/science/Pope&Kwapil2000.pdf]]</ref> | |||
|- | |||
| [[Motivation suppression]] || [[Motivation suppression]] || Reduced motivation considered central to the negative symptoms of schizophrenia <ref>Amotivation as central to negative schizotypy and their predictive value for happiness | https://www.sciencedirect.com/science/article/abs/pii/S0191886914002074</ref> | |||
|- | |||
| NMDA antagonism || Cannabinoid receptor agonism || Schizophrenia associated with reduced NMDA receptor activation and increased endocannabinoid activity <ref>Comparative psychopharmacology of autism and psychotic-affective disorders suggests new targets for treatment | https://academic.oup.com/emph/article/2019/1/149/5554458 </ref> | |||
|} | |||
Revision as of 08:25, 10 September 2022
Psychoactive Substances that Mimic Psychiatric Disorders
Dissociatives & Cannabis - Schizophrenia
| Dissociatives | Cannabis | Schizophrenia/Schizotypy |
|---|---|---|
| Personal meaning enhancement | Personal meaning enhancement | Positive symptoms of schizophrenia and schizotypy are associated with & thought to be caused by aberrant salience (the scientific term for personal meaning enhancement)[1] |
| Paranoia | Paranoia | Paranoia considered to be diagnostic of schizophrenia spectrum disorders [2] |
| Creativity enhancement | Creativity enhancement | A massive body of evidence shows a robust association with schizophrenia, schizotypy, and creativity [3] |
| Auditory hallucinations | Auditory hallucinations | Auditory hallucinations [4] |
| Delusion | Delusion | Delusion [5] |
| Auditory and visual suppression | Auditory and visual suppression | Schizophrenia associated with reduced sensory abilities [6] |
| Empathy enhancement | Empathy enhancement | Positive symptoms of schizophrenia and schizotypy associated with dysfunctionally increased cognitive empathy[7] |
| Pain relief | Pain relief | Schizophrenia associated with reduced sensitivity to pain [8] |
| Depersonalization && Derealization | Depersonalization && Derealization | Dissociation & depersonalization associated with schizotypy & schizophrenia [9] |
| Motivation suppression | Motivation suppression | Reduced motivation considered central to the negative symptoms of schizophrenia [10] |
| NMDA antagonism | Cannabinoid receptor agonism | Schizophrenia associated with reduced NMDA receptor activation and increased endocannabinoid activity [11] |
- ↑ The Aberrant Salience Inventory: A New Measure of Psychosis Proneness | https://psychology.unt.edu/sites/default/files/ASI.pdf
- ↑ Schizotypal personality disorder: A current review | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182925/
- ↑ Imagination in human social cognition, autism, and psychotic-affective conditions | https://www.sfu.ca/biology/faculty/crespi/pdfs/186-Cognition.pdf
- ↑ Psychosis and autism as diametrical disorders of the social brain | http://eprints.lse.ac.uk/21571/1/Psychosis%20and%20autism%20as%20diametrical%20disorders%20of%20the%20social%20brain%20(LSERO).pdf
- ↑ Psychosis and autism as diametrical disorders of the social brain | http://eprints.lse.ac.uk/21571/1/Psychosis%20and%20autism%20as%20diametrical%20disorders%20of%20the%20social%20brain%20(LSERO).pdf
- ↑ Imagination in human social cognition, autism, and psychotic-affective conditions | https://www.sfu.ca/biology/faculty/crespi/pdfs/186-Cognition.pdf
- ↑ Psychosis and autism as diametrical disorders of the social brain | http://eprints.lse.ac.uk/21571/1/Psychosis%20and%20autism%20as%20diametrical%20disorders%20of%20the%20social%20brain%20(LSERO).pdf
- ↑ Decreased pain sensitivity among people with schizophrenia: a meta-analysis of experimental pain induction studies | https://gala.gre.ac.uk/id/eprint/15830/1/15830_Thompson_Decreased%20pain%20sensitivity%20%28AAM%29%202015.pdf
- ↑ Dissociative Experiences in Hypothetically Psychosis-Prone College Students|https://www.empty-memories.nl/science/Pope&Kwapil2000.pdf]]
- ↑ Amotivation as central to negative schizotypy and their predictive value for happiness | https://www.sciencedirect.com/science/article/abs/pii/S0191886914002074
- ↑ Comparative psychopharmacology of autism and psychotic-affective disorders suggests new targets for treatment | https://academic.oup.com/emph/article/2019/1/149/5554458