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Template:SubstanceBox/Buprenorphine: Difference between revisions

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     |InsufflatedROA_Collapsed=
     |InsufflatedROA_Collapsed=
     |InsufflatedROA_Caption=
     |InsufflatedROA_Caption=
     |InsufflatedROA_Bioavailability=48%<ref>The systemic availability of buprenorphine administered by nasal spray. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/2576057</ref>
     |InsufflatedROA_Bioavailability=48%<ref name="Eriksen1989">{{cite journal | vauthors=((Eriksen, J.)), ((Jensen, N. H.)), ((Kamp-Jensen, M.)), ((Bjarnø, H.)), ((Friis, P.)), ((Brewster, D.)) | journal=The Journal of Pharmacy and Pharmacology | title=The systemic availability of buprenorphine administered by nasal spray | volume=41 | issue=11 | pages=803–805 | date= November 1989 | issn=0022-3573 | doi=10.1111/j.2042-7158.1989.tb06374.x}}</ref>
     |InsufflatedROA_Threshold=< 0.2 mg
     |InsufflatedROA_Threshold=< 0.2 mg
     |InsufflatedROA_Light=0.2 - 0.4 mg
     |InsufflatedROA_Light=0.2 - 0.4 mg
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     |SublingualROA_Collapsed=true
     |SublingualROA_Collapsed=true
     |SublingualROA_Caption=
     |SublingualROA_Caption=
     |SublingualROA_Bioavailability= 30%<ref>Bioavailability of sublingual buprenorphine. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/9048270</ref>
     |SublingualROA_Bioavailability= 30%<ref name="Mendelson1997">{{cite journal | vauthors=((Mendelson, J.)), ((Upton, R. A.)), ((Everhart, E. T.)), ((Jacob, P.)), ((Jones, R. T.)) | journal=Journal of Clinical Pharmacology | title=Bioavailability of sublingual buprenorphine | volume=37 | issue=1 | pages=31–37 | date= January 1997 | issn=0091-2700 | doi=10.1177/009127009703700106}}</ref>
     |SublingualROA_Threshold=<0.3 mg
     |SublingualROA_Threshold=<0.3 mg
     |SublingualROA_Light=0.3 - 0.6 mg
     |SublingualROA_Light=0.3 - 0.6 mg

Revision as of 22:17, 27 July 2022

SubstanceBox/Buprenorphine
Chemical Nomenclature
Common names Buprenex, Subutex, Butrans, Cizdol, Addnok, Transtec
Systematic name (2S)-2-[(5R,6R,7R,14S)-9α-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylbutan-2-ol
Class Membership
Psychoactive class Opioid
Chemical class Morphinan
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.





Sublingual
Dosage
Bioavailability 30%[1]
Threshold <0.3 mg
Light 0.3 - 0.6 mg
Common 0.6 - 1.3 mg
Strong 1.3 - 2.4 mg
Heavy 2.4 mg +
Duration
Total 18-24 hours
Onset 40 - 80 minutes
Peak 1.5-2 hours
After effects 1 - 3 days
Insufflated
Dosage
Bioavailability 48%[2]
Threshold < 0.2 mg
Light 0.2 - 0.4 mg
Common 0.4 - 0.8 mg
Strong 0.8 - 1.5 mg
Heavy 1.5 mg +
Duration
Total 8 - 14 hours
Onset 30 - 60 minutes
Peak 4 - 8 hours
After effects 1 - 3 days






DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

  1. Mendelson, J., Upton, R. A., Everhart, E. T., Jacob, P., Jones, R. T. (January 1997). "Bioavailability of sublingual buprenorphine". Journal of Clinical Pharmacology. 37 (1): 31–37. doi:10.1177/009127009703700106. ISSN 0091-2700. 
  2. Eriksen, J., Jensen, N. H., Kamp-Jensen, M., Bjarnø, H., Friis, P., Brewster, D. (November 1989). "The systemic availability of buprenorphine administered by nasal spray". The Journal of Pharmacy and Pharmacology. 41 (11): 803–805. doi:10.1111/j.2042-7158.1989.tb06374.x. ISSN 0022-3573.