Substituted amphetamines

General formula of amphetamine molecule.

Substituted amphetamines, also known as amphetamines, are a class of chemicals that include compounds with psychoactive effects.

Chemistry

Substituted amphetamines are a chemical class based upon the molecule amphetamine. Amphetamine is made up of a phenethylamine molecule. The chemical structure of a substituted amphetamine is the same as the organic molecule amphetamine, except some substitutions are made at the phenyl and amine sites, typically of methyl and ethyl chains.

Pharmacology

The substituted amphetamine class of psychedelic, entactogenic and stimulant drugs works via their action upon numerous receptors. Psychedelic effects can be attributed to action on the 5-HT_2A receptor. Entactogenic and stimulant effects are due to their action as releasing agents of serotonin, adrenaline and noradrenaline; or as agonists on the receptors of the previous neurotransmitters.

Examples

Substituted amphetamines are seen throughout organic chemistry, and include many psychoactive drugs.

Psychedelic Drugs

• MDA
• DOM
• DOB
• DOC

Stimulants and Entactogens:

• MDMA
• Amphetamine
• Methamphetamine
• Mephedrone
• Cathinone

See Also

• Psychedelics
• Phenethylamines
• Entactogens
• Stimulants