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*'''[[Effect::Seizure suppression]]''' - Tizanidine has been found to suppress strycnine induced seizures, but not GABA induced seizures.
*'''[[Effect::Sedation]]'''
*'''[[Effect::Sedation]]''' - Tizanidine can produce a strong sedative effect. Users can become very tired and sleep through stimuli that would otherwise wake them.
*'''[[Effect::Pain relief]]'''
*'''[[Effect::Pain relief]]'''
*'''[[Effect::Muscle relaxation]]'''
*'''[[Effect::Muscle relaxation]]'''
*'''[[Effect::Physical euphoria]]'''
*'''[[Effect::Physical euphoria]]''' - This effect is very mild and may not be pronounced at all in some users.
*'''[[Effect::Lip numbing]]'''
*'''[[Effect::Lip numbing]]''' - Numbing of the lips only occurs at higher doses as a result of low blood pressure.
*'''[[Effect::Perception of bodily heaviness]]'''
*'''[[Effect::Perception of bodily heaviness]]'''
*'''[[Effect::Decreased blood pressure]]'''
*'''[[Effect::Decreased blood pressure]]'''
*'''[[Effect::Increased heart rate]]'''
*'''[[Effect::Decreased heart rate]]'''
*'''[[Effect::Dizziness]]'''
*'''[[Effect::Abnormal heartbeat]]'''
*'''[[Effect::Headache]]'''
*'''[[Effect::Dizziness]]''' - Because of the cardiovascular effects of tizanidine, users can become dizzy or lightheaded.
*'''[[Effect::Headache]]''' - When taking excessive doses, headaches are a common side effect.
*'''[[Effect::Watery eyes]]'''
*'''[[Effect::Watery eyes]]'''
*'''[[Effect::Physical fatigue]]'''
*'''[[Effect::Pupil constriction]]'''
*'''[[Effect::Dry mouth]]'''
}}
}}
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At high doses, geometry can be observed likely due to experiencing low blood pressure and circulation to the brain. The geometry is distinct from psychedelic and dissociative drugs. It can be described as intricate in complexity, abstract in form, synthetic in feel, unstructured in organization, dimly lit, multicolored in scheme, flat in shading, soft in edges, smooth in motion, slow in speed, small in size, angular in corners, non-immersive in depth, and consistent in intensity.
At high doses, geometry can be observed likely due to experiencing low blood pressure and circulation to the brain. The geometry is distinct from psychedelic and dissociative drugs. It can be described as intricate in complexity, abstract in form, synthetic in feel, unstructured in organization, dimly lit, multicolored in scheme, flat in shading, soft in edges, smooth in motion, slow in speed, small in size, angular in corners, non-immersive in depth, and consistent in intensity.
The geometry of Tizanidine never exceeds level 4. The doses required to observe such geometries can induce dangerously low blood pressures and cause one to lose consciousness.
The geometry of Tizanidine never exceeds level 4. The doses required to observe such geometries can induce dangerously low blood pressures and cause one to lose consciousness. Users should exercise caution when taking hallucinogenic doses, as the threshold for hallucinations is not far from the threshold for psychosis in many users.
====Hallucinatory states====
====Hallucinatory states====
In higher doses, Tizanidine is capable of inducing a delirious state.
In higher doses, Tizanidine is capable of inducing a delirious state.
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|{{effects/cognitive|
|{{effects/cognitive|
If applicable, a brief paragraph summary of the substance's cognitive effects may be included here.
You may select from a list of cognitive effects to add below [[Subjective effect index#Cognitive effects|here]].
*'''[[Effect::Dream potentiation]]'''
*'''[[Effect::Cognitive fatigue]]'''
*'''[[Effect::Dream potentiation]]''' - Some users of tizanidine notice strange or increasingly vivid dreams after continuous use of tizanidine.
*'''[[Effect::Focus suppression]]'''
*'''[[Effect::Focus suppression]]'''
*'''[[Effect::Anxiety suppression]]'''
*'''[[Effect::Anxiety suppression]]'''
*'''[[Effect::Memory suppression]]'''
*'''[[Effect::Memory suppression]]''' - This effect occurs at higher doses
*'''[[Effect::Thought deceleration]]'''
*'''[[Effect::Thought deceleration]]'''
*'''[[Effect::Delirium]]''' - At extremely high doses, delirium can be induced.
*'''[[Effect::Delirium]]''' - At extremely high doses, delirium can be induced.
*'''[[Effect::Sleepiness]]''' - This is the most prevalent cognitive effect of Tizanidine
*'''[[Effect::Sleepiness]]''' - This is the most prevalent cognitive effect of Tizanidine
}}
{{effects/aftereffects|
*'''[[Effect::Increased heart rate]]''' - This occurs as a rebound effect to tizanidine's cardiovascular effects and typically presents itself after prolonged use.
*'''[[Effect::Increased blood pressure]]''' - This occurs as a rebound effect to tizanidine's cardiovascular effects and typically presents itself after prolonged use.
*'''[[Effect::Irritability]]'''
*'''[[Effect::Soreness]]''' - After the effects of tizanidine wear off, muscles that weren't sore before using the drug can become sore with more ease. For most users, this first presents itself as an increased soreness in the neck.
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Tizanidine (known by the trade names Zanaflex and Trinex among others) is a depressant substance of the imidazoline class. Tizanidine is primarily used primarily as an antispasmodic drug.
Tizanidine is a central α2 receptor agonist. The relationship between the α2 receptor agonism and the spasmolytic function of tizanidine is not fully understood.
Tizanidine is an imidazoline derivative and centrally acting α2 receptor agonist closely related to Clonidine. Tizanidine inhibits the release of excitatory amino acids from spinal interneurons. As a result, Tizanidine enhances the presynaptic inhibition of motor neurons.
Tizanidine also has some affinity for the α1 receptors, but to a lesser than Clonidine, which may explain why its cardiovascular effects are so much milder than that of Clonidine.
Tizanidine has also been found to have anticonvulsant effects against strychnine-induced seizures but not against GABA-induced seizures. The α2 receptor mediated inhibition of inter-neuronal activity appears to be the cause of Tizanidine's anti-convulsant properties.
Tizanidine has an oral bioavailability of 20-34% and an elimination half-life of 2.5 hours. It attains steady-state concentration within 24-48 hours after administration.
Subjective effects
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
Seizure suppression - Tizanidine has been found to suppress strycnine induced seizures, but not GABA induced seizures.
Sedation - Tizanidine can produce a strong sedative effect. Users can become very tired and sleep through stimuli that would otherwise wake them.
At high doses, geometry can be observed likely due to experiencing low blood pressure and circulation to the brain. The geometry is distinct from psychedelic and dissociative drugs. It can be described as intricate in complexity, abstract in form, synthetic in feel, unstructured in organization, dimly lit, multicolored in scheme, flat in shading, soft in edges, smooth in motion, slow in speed, small in size, angular in corners, non-immersive in depth, and consistent in intensity.
The geometry of Tizanidine never exceeds level 4. The doses required to observe such geometries can induce dangerously low blood pressures and cause one to lose consciousness. Users should exercise caution when taking hallucinogenic doses, as the threshold for hallucinations is not far from the threshold for psychosis in many users.
Hallucinatory states
In higher doses, Tizanidine is capable of inducing a delirious state.
Soreness - After the effects of tizanidine wear off, muscles that weren't sore before using the drug can become sore with more ease. For most users, this first presents itself as an increased soreness in the neck.
Experience reports
There are currently 0 experience reports which describe the effects of this substance in our experience index.
This toxicity and harm potential section is a stub.
As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.
The LD50 of oral tizanidine in rats was found to be 414mg/kg in rats and 235 mg/kg in mice.
Tolerance and addiction potential
While dependence is rare, use of Tizanidine exceeding 36mg daily over an extended period of time can lead to hypertensive withdrawals. In cases where dependence has been built, a user should taper to avoid a hypertensive crisis.
Warning:Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
