DXM & DPH: Difference between revisions

Revision as of 13:05, 23 November 2021

- I find the title DXM & DPH to be the most alluring title for this article, tho we could use DXM + DPH as well (or both)

My notes (heavily disorganized)

The combination of Dextromethorphan (DXM) and Diphenhydramine (DPH, avoid DMH), also called "Over-The-Counter Flipping" synergizes verz well and can become extremely powerful, profound and detaching from reality.

When using both DXM and DPH in high doses, effects can become extremely bizarre in nature, have profound experiences, overwhelming confusion

Most importantly for harm reduction, i can easily become very dangerous, both physically and psychologically (and somewhat socially).

This short guide will summarize the important rules and harm reduction practises you absolutely should use, else you might, without prior knowledge, get in a **real** bad mess, accident or pay a sum of money, if you don't respect the dosages and the very powerful synergy.

It's very easy to fall into a full-blown delirium, akin to Datura?, and you may wake up somewhere you don't want to be or don't know where you are.

The combination is presumably also very straining on your heart and circulation. People with cardiovascular problems shoud not try this!

Introduction

DXM and DPH, in recreational doses, synergize unusually favorable with each other. Most negative effects of one drug is masked by the other, especially the dysphoric headspace of DPH, or the nausea and body load from DXM. They produce a sort of entirely new experience with features of both drugs in addition to synergestic effects that form, which can become quite strong.

Psychological Effects

The dissociation from DXM is amplified with DPH's deliriant and short-term + long-term amnesia, which can quickly turn into delirium. Approaching delirium the trip suddenly can become stimulating/energetic and one might end up moving or walking for some (or very long) distance without being coherent.

DXM lowers the delirium theshold of DPH significantly. Dosages with this combination should be greatly respected and anyone should have a sober person by his/her side at all times. In some people a dose of 300mg/300mg could already be sufficient for full-blown delirium (not being able to differentiate reality). __This is extremely dangerous when one finds themselves alone__.

DPH can reduce nausea from DXM and it masks the body load that some users percieve differently DPH also adds to memory blackouts

The synergestic effects are very diverse for each type. Perception itself includes a kind of stimulated, strongly dissociating and also from delusions to full-blown delirium, which can completely renders the user unable to differentiate hallucinations from reality, not even capable of using logic.

Extremely realistic and diverse external hallucinations occur, ranging from well-defined, mostly known people, insects, imaginary passages or groups of obstacles (branches, trees..), unrealistic objects of any absurd kind, usually with some correlation to a delusional thought. Even entire sceneries can form, e.g. social gatherings, implementing many of the previously mentioned hallucinations. Just like DPH Delirium, hallucinations appear 99% realistic and even after the trip is gone you still don't know what has been real or not in your trip. Hallucinations mostly feel casual, as if they were normal, despite a terrorizing nature, but can also feel very stressful or terrorizing nonetheless. This is most likely due to the DXM. The dysphoria from DPH is practically gone.

Internal hallucinations can develop occasinally and are typicakly sinister or bizzare sceneries, more detailed than DPH and less harmless/fun/strange visions of DXM. They are more common on low to moderate doses.

Closed-eye geometry is defined, they resemble DXM although they transform very slow, jittery and occasionally freeze up entirely, then spontaneously transform into internal hallucinations or geometry again.

Thought process can range from intoxixation to delusions+blackouts and finally full-blown delirium. Of couse, basic physical movements are still there although muscle coordination can be very bad, hideous and clumsy at times.

The experience can be perceived in many different but extreme feelings of euphoria, profoundness, confusion, casuality, fear, terror, dissociation, frustration, disinhibition and more. The trip will play out what experience or scenery you have.

Physical Effects

There is a pleasant numb/warm feeling across the body.

DXM and DPH both increase heart rate, possibly to very strenuous levels that can turn dangerous. Very high doses should be avoided because of this.

Duration

Depending on dose, peak effects last between 6 - 12 hours and the total duration approximately 12- 20 hours. Please note these estimates are purely from my own experience.

Dosage

Be sure that DXM and DPH are the ONLY active ingredients, some can get dangerous when also added.

Also avoid ANY other drug combination, including ALL safe ones for DXM and DPH, Nicotine, Caffeine, Grapefruit juice, medication and preferably cannabis.

If you don't decide to dose lower on either DPH or DXM in the combination, you can follow this starting recommendation for the full effects from both drugs:

Light: 120mg/120mg Common: 200mg/200mg Strong: 280mg/280mg (possible to fall into delirium) Heavy: 350mg/350mg (slowly work up before trying) Maximum: 400mg/400mg (possibly unsafe physicaly. Do not exceed, even experienced users)

Guide & Preparation to enjoy DXM + DPH as safely as possible.

There is quite a few key points that are absolutely neccesary to follow, or else bad things might happen. The Combo is also only recommended for experienced people, with both DXM and DPH both alone!

• Have one or more sober tripsitters that you have good relationships with. They should always be watching you at all times. Might be the most important requirement to prevent any trainwrecks or some Hangover Movie thing.

Even for experienced users, never take this combo alone, notably high doses. You could wake up somewhere far away, get in a fight or loose all your belongings.

You should be aware that you'll appear very inappropriate in front of other people so avoid public spaces and people you dont trust.

• No exceptions: Start low! The combination can be very powerful and incapacitating. Starting at 200mg/200mg is recommended.

• A good setting and enough time. I'd recommend first time to only stay at home and have 24 hours to spare.

• Water, little food, nutrients, vitamins. 1. Drink enough water! 2. Magnesium, Potassium, little Sodium should be taken to replenish what the DXM takes away. 3. DMAE, Alpha-GPC or another choline source will counteract some of the anticholinergic effects.

• Preferably a heart-rate monitor and/or blood pressure monitor to check if your circulation is OK.

• Avoid any significant exercise. Avoid driving or machinery. (Depending on your state you'd never be able to come up with such an idea anyway)

personal xp vo PC

add from notes

Old psychonaut article

Summary sheet: DXM & DPH

Talk:SubstanceBox/DXM&DPH

This article is going to serve as a complete breakdown and categorization for the consistent subjective effects that are induced across all people who undergo the DXM and DPH combination experience. This is something that PsychonautWiki is documenting because although there are an infinite amount of possible drug combinations, almost all of them simply induce the effects of the two separate drugs on top of each other in a very predictable manner. However, these two substances do just the opposite of that, producing a very unique synergy when taken together, potentiating the positive aspects of the other substance whilst simultaneously suppressing its negative side effects; all with distinct visual and hallucinatory effects that are found on neither of these substances when taken on their own. Contents

Chemistry

DXM falls into the morphinan class of drugs. DPH falls into the antihistamine class of drugs. Pharmacology DXM Main article: NMDA receptor antagonist

DXM acts as an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurones in the brain and spinal column; for the signals to pass, the receptor must be open. NMDA receptor antagonists close the NMDA receptors by blocking them. This disconnection of neurones leads to loss of feeling, difficulty moving, and eventually the famous “hole”.

The mechanism of action behind DXM is via multiple effects, including actions as a nonselective serotonin reuptake inhibitor[1] and a sigma-1 receptor agonist.[2][3] Dextrorphan

Dextrorphan is produced by O-demethylation of dextromethorphan through the CYP2D6 enzyme and contributes to the psychoactive effects of dextromethorphan.[4] It is pharmacologically similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an NMDA receptor antagonist as well as essentially inactive as a serotonin reuptake inhibitor.[5] DPH

DPH is an inverse agonist of the histamine H1 receptor, and is also a competitive antagonist at mACH receptors. This substance works via its antagonistic action on acetylcholine receptors. It’s this inhibition of acetylcholine which leads to delirium, sedation and intensely realistic hallucinations alongside some extremely uncomfortable and dysphoric physical side effects. Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects. Physical effects

When taken in combination, DXM and DPH both lessen the negative side effects of the other substance. For example, due to DPH’s nausea suppressing abilities, the nausea associated with DXM is almost entirely abscent. In return, DXM’s dissociating and anesthetic-like qualities have an extremely positive effect on the unbearably strong physical dysphoria found within DPH. This completely eliminates the muscle cramps, nausea, dizziness, drowsiness, restless leg syndrome, and extreme dehydration experienced when DPH is tried by itself. This allows the unique delirium, hallucinations and visual effects of the DPH experience to become much more accessible to your average person.

The subjective physical effects of DXM and DPH can be broken down into several components all of which progressively intensify proportional to dosage. These components generally include:

   Tactile disconnection
   Spontaneous tactile sensations - The body high is a sharp, pleasurable tingling sensation which is location specific to the hands, feet and head. The second is a warm euphoric glow which emanates outwards from the centre of the body's torso.
   Increased bodily weight - A powerful increase in the body's overall weight and sense of gravity is felt.
   Physical autonomy
   Cough suppression

Cognitive effects

The emotional dysphoria, paranoia, anxiety, depression and feelings of impending doom usually found within DPH do not seem to present when taken in combination with DXM. This could be attributed to DXM's euphoric and calming effects. In total the subjective cognitive effects of DXM and DPH can be broken down into several components all of which progressively intensify proportional to dosage. These components generally include:

   Consciousness disconnection
   Memory suppression
   Thought deceleration
   Emotion suppression
   Information processing suppression
   Language suppression
   Amnesia
   Simultaneous emotions

Visual effects Suppression

This combination does not enhance visual stimuli in the way that psychedelics do; instead they tend to degrade and decrease visual aptitude both increasing hallucination and degrading vision. These are described below and generally include:

   Acuity suppression
   Double vision
   Pattern recognition suppression
   Visual disconnection

Distortions

As for visual distortions and alterations, effects experienced are detailed below:

   Drifting (melting, breathing, morphing and flowing) - In comparison to other hallucinogens, this effect can be described as intricate in complexity, jittery, slow and rigid in motion, static in their permanence, blurry in detail, realistic in believability, and interactive in plasticity
   3-Dimensional textures - Another distinct visual distortion which is seemingly unique to this very specific combination is a distortion which exclusively effects rough and detailed textures. This causes textures to become 3-Dimensional, rising up out of the surface which they reside upon in a strangely intricate and static fashion that looks similar in appearance to condensed, mostly opaque and coloured smoke.

Geometry

In terms of the specific style of geometry present within this combination, they can be described as intricate in complexity, slow in movement, dark in colour scheme and ominous in emotional vibe. They manifest themselves in a traditional psychedelic manner when the eyes are closed but appear as static, unmoving shapes and geometry which the external environment morphs into when the eyes are open and looking at any single point, always resetting once the person double takes. This is an unusual visual effect because both dissociative and psychedelic visuals do not do this, instead preferring to manifest themselves as a fast moving and flat translucent veil across the visual field which cannot be interacted with. Hallucinatory states

The effects of this combination are extremely efficient at inducing delirious hallucinations which can be broken into the two categories described below:

   External hallucinations ([Effect::Autonomous entities]], Settings, sceneries, and landscapes, Alterations in perspective and Scenarios and plots) - In comparison to other classes of hallucinogen, this effect occurs more frequently than that of any other at moderate to heavy dosages and is the defining feature of the experience. It can be comprehensively described through its variations as delirious in believability, autonomous in controllability and solid in style. The most common themes for these hallucinations include those of both everyday occurrences such as smoking phantom cigarettes, talking to people who are not there, insects and sinister, nightmarish experiences.
   Internal hallucinations (Autonomous entities, Settings, sceneries, and landscapes, Alterations in perspective and Scenarios and plots) - In comparison to other classes of hallucinogen, this effect occurs briefly and spontaneously at moderate dosages but becomes progressively extended in its occurrence and duration proportional to dosage before eventually becoming all encompassing. It can be comprehensively described through its variations as delirious in believability, interactive in style, equal in new experiences and memory replays in content, autonomous in controllability and solid in style.
   Unspeakable horrors
   Shadow people

Auditory effects

The auditory effects of this combination are extremely consistent in occurrence in comparison to that of LSD and psilocin and exhibit a range of effects which commonly includes:

   Suppression
   Distortions
   Hallucinations

Toxicity and harm potential

   DXM Toxicity
   DPH Toxicity

Legal issues

   DXM Legality
   DPH Legality

@@ Line 132: / Line 132: @@
 {{SummarySheet}}
-{{SubstanceBox/DXM&DPH}}
+{{Talk:SubstanceBox/DXM&DPH}}
 This article is going to serve as a complete breakdown and categorization for the consistent subjective effects that are induced across all people who undergo the DXM and DPH combination experience. This is something that PsychonautWiki is documenting because although there are an infinite amount of possible drug combinations, almost all of them simply induce the effects of the two separate drugs on top of each other in a very predictable manner. However, these two substances do just the opposite of that, producing a very unique synergy when taken together, potentiating the positive aspects of the other substance whilst simultaneously suppressing its negative side effects; all with distinct visual and hallucinatory effects that are found on neither of these substances when taken on their own.

DXM & DPH: Difference between revisions

Revision as of 13:05, 23 November 2021

My notes (heavily disorganized)

Old psychonaut article

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