This is an unofficial archive of PsychonautWiki as of 2025-08-11T15:14:44Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
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|OralROA_Bioavailability=[[Oral min bioavailability::x]]% - [[Oral max bioavailability::y]]%<ref>APA formatted citation.</ref> <!-- Refer to this tool to generate APA citations from DOI links: https://reftag.appspot.com/doiweb.py -->
|InsufflatedROA_Light=[[Insufflated min light dose::x]] - [[Insufflated max light dose::y]] mg
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|InsufflatedROA_Strong=[[Insufflated min strong dose::x]] - [[Insufflated max strong dose::y]] mg
|InsufflatedROA_Strong=[[Insufflated min strong dose::70]] - [[Insufflated max strong dose::120]] mg
|InsufflatedROA_Heavy=[[Insufflated heavy dose::x]] mg +
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|InsufflatedROA_Duration=[[Insufflated min total time::x]] - [[Insufflated max total time::y]] [[Insufflated total time units::hours]]
|InsufflatedROA_Duration=[[Insufflated min total time::4]] - [[Insufflated max total time::8]] [[Insufflated total time units::hours]]
|InsufflatedROA_Onset=[[Insufflated min onset time::x]] - [[Insufflated max onset time::y]] [[Insufflated onset time units::minutes]]
|InsufflatedROA_Onset=[[Insufflated min onset time::10]] - [[Insufflated max onset time::30]] [[Insufflated onset time units::minutes]]
|InsufflatedROA_Comeup=[[Insufflated min comeup time::x]] - [[Insufflated max comeup time::y]] [[Insufflated comeup time units::minutes]]
|InsufflatedROA_Comeup=[[Insufflated min comeup time::20]] - [[Insufflated max comeup time::40]] [[Insufflated comeup time units::minutes]]
|InsufflatedROA_Peak=[[Insufflated min peak time::x]] - [[Insufflated max peak time::y]] [[Insufflated peak time units::hours]]
|InsufflatedROA_Peak=[[Insufflated min peak time::1.5]] - [[Insufflated max peak time::4]] [[Insufflated peak time units::hours]]
|InsufflatedROA_Offset=[[Insufflated min offset time::x]] - [[Insufflated max offset time::y]] [[Insufflated offset time units::hours]]
|InsufflatedROA_Offset=[[Insufflated min offset time::2]] - [[Insufflated max offset time:4]] [[Insufflated offset time units::hours]]
|InsufflatedROA_Aftereffects=[[Insufflated min afterglow time::x]] - [[Insufflated max afterglow time::y]] [[Insufflated afterglow time units::hours]]
|InsufflatedROA_Aftereffects=[[Insufflated min afterglow time::2]] - [[Insufflated max afterglow time:7]] [[Insufflated afterglow time units::hours]]
|RectalROA=false
|RectalROA=false
Revision as of 21:29, 28 September 2021
This article is in the 'Talk' namespace because it is an unfinished draft. This section is used to host drafts for unpublished articles as well as discussions for published ones. If you'd like to use this area to discuss this draft, please do so in the 'Discussion' section at the very bottom of the page. This notice will be removed once this draft has been approved for publication by an administrator.
It may contain incorrect information, particularly with respect to dosage, duration, subjective effects, toxicity and other risks. It may also not meet PW style and grammar standards.
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
a"a" is not a number. - b"b" is not a number. hours
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Limited data exists about the pharmacological properties, metabolism, and toxicity of HXE in humans, and it has a limited history of human use. It is highly advised to use harm reduction practices if using this substance.
HXE first appeared for sale on the online research chemical market in late 2020.
Chemistry
HXE or 2-(Ethylamino)-2-(3-hydroxyphenyl)cyclohexan-1-one is classed as an Arylcyclohexylamine
Pharmacology
Very little is known about the pharmacology about this substance, however as an arylcyclohexamine it is reasonable to assume that it is an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “k-hole.”
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
If applicable, a brief paragraph summary of the substance's physical effects may be included here.
You may select physical effects to add below here.
If applicable, a brief paragraph summary of the substance's cognitive effects may be included here.
You may select from a list of cognitive effects to add below here.
If applicable, a brief paragraph summary of the substance's auditory effects may be included here.
You may select from a list of auditory effects to add below here.
If applicable, a brief paragraph summary of the substance's multisensory effects may be included here.
You may select from a list of multisensory effects to add below here.
If applicable, a brief paragraph summary of the substance's transpersonal effects may be included here.
You may select from a list of transpersonal effects to add below here.
This toxicity and harm potential section is a stub.
As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.
The toxicity and long-term health effects of recreational HXE use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because HXE has very little history of human usage.
Warning:Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
