Substituted tropanes: Difference between revisions
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[[File:tropane.png|thumb|200px|right|General tropane molecule]] | [[File:tropane.png|thumb|200px|right|General tropane molecule]] | ||
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''' | '''Substituted tropanes''' are a group of [[psychoactive compounds]] that include a tropane ring in their structure. Prominent examples include certain [[stimulants]] like [[cocaine]] and its derivatives as well as [[deliriants]] like [[atropine]] and [[scopolamine]]. | ||
==Chemistry== | ==Chemistry== | ||
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*[[JZ-IV-10 ]] | *[[JZ-IV-10 ]] | ||
*[[Tesofensine]] | *[[Tesofensine]] | ||
==See also== | ==See also== | ||
Revision as of 22:37, 5 June 2020
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This article is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it. |
Substituted tropanes are a group of psychoactive compounds that include a tropane ring in their structure. Prominent examples include certain stimulants like cocaine and its derivatives as well as deliriants like atropine and scopolamine.
Chemistry
Tropane alkaloids are molecules which contain a substituted tropane ring in their structure. Tropane is a nitrogen-containing bicyclic organic molecule which consists of a piperidine and pyrrolidine ring fused at carbons R1 and R5 along with an additional methyl substitution at RN. Tropane alkaloids are commonly substituted at R3 with an ether bridge (as seen in scopolamine, atropine, hyoscyamine, and cocaine).
Pharmacology
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Tropane alkaloids are mostly anti-cholinergics (antagonistic action on acetylcholine receptors) or stimulants (prevention of dopamine reuptake).
Examples
Tropane alkaloids are seen throughout organic chemistry and include psychoactive and anaesthetic compounds.
Anticholinergic drugs:
Stimulant drugs:
- Cocaine
- RTI-111
- REC
- Diclofensine
- RTI-126
- RTI-31
- 2-HO-Cocaine
- 4-Fl-Cocaine
- DOV-102677
- EXP-561
- GSK1360707F
- JZ-IV-10
- Tesofensine
See also
External links
References
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