Talk:Substituted pyrrolidinophenones

Generic structure of pyrrolidinophenone molecule.

Substituted pyrrolidinophenones are a chemical class of psychoactive compounds that are based on the structure of alpha-pyrrolidinopropiophenone (α-PPP). Pyrrolidinophenones have stimulant effects and are presumed to be more potent and addictive than others stimulants of class amphetamine and cathinone.

Chemistry

Pyrrolidinophenones are a chemical class releated to cathinones, and they differs from other cathinones in that they contains a pyrrolidine ring in amino group.

Pharmacology

Presence of a pyrrolidine ring in any cathinone-like compound confers potent uptake blocking properties at DAT and NET. Thus, pyrrolidinophenones are mechanistically distinct from ring-substituted cathinones, such as mephedrone and methylone, which act as non-selective substrates for monoamine transporters and trigger transmitter release. Importantly, MDPV and α-PVP are similar in potency and transporter selectivity, indicating that the presence of the 3,4-methylenedioxy substituent in MDPV does not exert much influence on the profile of transporter activity. By contrast, alkyl chain length extending from the α-carbon is a critical structural feature, with shorter chain length (i.e., α-PPP, methyl) yielding less potent transporter-blocking properties when compared to longer chain length (i.e., α-PVP, propyl).

List of substituted pyrrolidinophenones

Compound	R2	R3	R4	R5	Rα	Structure
α-PPP	H	H	H	H	H
α-PVP	H	H	H	H	CH2CH3
α-PHP	H	H	H	H	CH2CH2CH3
α-PHpP	H	H	H	H	CH2CH2CH2CH3
MDPV	H	OCH2-	O-	H	CH2CH3
MDPHP	H	OCH2-	O-	H	CH2CH2CH3

See also

• Responsible use
• Research chemicals
• Stimulants
• Cathinones

External links

• Pyrrolidinophenone (Wikipedia)

References

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