Talk:Piperine: Difference between revisions
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Latest revision as of 08:45, 28 June 2019
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Piperine, along with its isomer chavicine, is the alkaloid responsible for the pungency of black pepper and long pepper. Piperine is commercially available as an extract from black pepper using dichloromethane.[1] Piperine is believed to increase the bioavaliability of a wide range of substances, hypothetically increasing their potency at the cost of duration.
Piperine can be supplemented in the dosage range of 2-5mg for the purpose of potentiating a desired drug's effect.
It should not to be confused with piperidine
Pharmacology
In the body, it has been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and metabolites.[2][3] In animal studies, piperine also inhibited other CYP 450 enzymes important for drug metabolism.[4]