Talk:Sertraline: Difference between revisions
>David Hedlund dup |
>Tracer m ===Experience reports=== Erowid Experience Vaults: Sertraline and ==External links== Sertraline (TiHKAL / Isomer Design) |
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*'''[[Effect::Suicidal ideation]]''' - Sertraline and other SSRIs can cause suicidal ideation.<ref>Didham, R. C., McConnell, D. W., Blair, H. J., & Reith, D. M. (2005). Suicide and self‐harm following prescription of SSRIs and other antidepressants: confounding by indication. British journal of clinical pharmacology, 60(5), 519-525.</ref> | *'''[[Effect::Suicidal ideation]]''' - Sertraline and other SSRIs can cause suicidal ideation.<ref>Didham, R. C., McConnell, D. W., Blair, H. J., & Reith, D. M. (2005). Suicide and self‐harm following prescription of SSRIs and other antidepressants: confounding by indication. British journal of clinical pharmacology, 60(5), 519-525.</ref> | ||
*'''[[Effect::Focus suppression]]''' | *'''[[Effect::Focus suppression]]''' | ||
===Experience reports=== | |||
There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]]. Additional experience reports can be found here: | |||
* [https://erowid.org/experiences/subs/exp_Pharms_Sertraline.shtml Erowid Experience Vaults: Sertraline] | |||
==See also== | ==See also== | ||
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*[https://en.wikipedia.org/wiki/Sertraline Sertraline (Wikipedia)] | *[https://en.wikipedia.org/wiki/Sertraline Sertraline (Wikipedia)] | ||
*[https://erowid.org/pharms/sertraline/ Sertraline (Erowid Vault)] | *[https://erowid.org/pharms/sertraline/ Sertraline (Erowid Vault)] | ||
*[https://isomerdesign.com/PiHKAL/explore.php?id=12068 Sertraline (TiHKAL / Isomer Design)] | |||
*[http://www.zoloft.com/ Zoloft website] | *[http://www.zoloft.com/ Zoloft website] | ||
Revision as of 13:07, 23 April 2019
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This page has not been fully approved by the PsychonautWiki administrators. It may contain incorrect information, particularly with respect to dosage, duration, subjective effects, toxicity and other risks. It may also not meet PW style and grammar standards. |
Serotonin syndrome and/or a prolonged heart QT interval can occur with using SSRIs (such as citalopram, paroxetine, or sertraline) with SNRIs, SRAs (such as MDMA), DXM, serotonergic stimulants (such as cocaine), MAOIs, and RIMAs.
It is strongly discouraged to consume moderate to heavy dosages of these substances together.
Sertraline (also known as Zoloft) is a widely-known SSRI substance and pharmaceutical of the substituted tametraline chemical class that produces anxiolytic and antidepressive effects when administered. Sertraline is primarily prescribed for major depressive disorder in adult outpatients as well as obsessive-compulsive disorder, panic disorder, and social anxiety disorder, in both adults and children.
Chemistry
Sertraline is a substituted tametraline.
Pharmacology
Sertraline is a selective reuptake inhibitor of serotonin; this allows sertraline to increase levels of extracellular serotonin, meaning that more serotonin comes into the brain. Sertraline is used for depression because it is hypothesized that people with depression have low serotonin levels.
Sertraline promotes neurogenesis (the growth of neurons). This is a useful property in neurodegenerative diseases, such as Huntington's disease.[1][2][3]
Its metabolite, norsertraline, also inhibits reuptake of serotonin, but more weakly than sertraline. [4][5]
Subjective effects
Physical effects
- Orgasm suppression
- Sedation - Sertraline is somewhat sedating or tiring.
- Increased perspiration
Cognitive effects
- Anxiety suppression - Sertraline is used clinically to reduce levels of anxiety in those with anxiety disorders.
- Suicidal ideation - Sertraline and other SSRIs can cause suicidal ideation.[6]
- Focus suppression
Experience reports
There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:
See also
External links
References
- ↑ Anacker, C., Zunszain, P. A., Cattaneo, A., Carvalho, L. A., Garabedian, M. J., Thuret, S., ... & Pariante, C. M. (2011). Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor. Molecular psychiatry, 16(7), 738.
- ↑ Peng, Q., Masuda, N., Jiang, M., Li, Q., Zhao, M., Ross, C. A., & Duan, W. (2008). The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model. Experimental neurology, 210(1), 154-163.
- ↑ Duan, W., Peng, Q., Masuda, N., Ford, E., Tryggestad, E., Ladenheim, B., ... & Ross, C. A. (2008). Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease. Neurobiology of disease, 30(3), 312-322.
- ↑ Koe, B. K., Weissman, A. L. B. E. R. T., Welch, W. M., & Browne, R. G. (1983). Sertraline, 1S, 4S-N-methyl-4-(3, 4-dichlorophenyl)-1, 2, 3, 4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin. Journal of Pharmacology and Experimental Therapeutics, 226(3), 686-700.
- ↑ Wong, D. T., Bymaster, F. P., & Engleman, E. A. (1995). Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication. Life sciences, 57(5), 411-441.
- ↑ Didham, R. C., McConnell, D. W., Blair, H. J., & Reith, D. M. (2005). Suicide and self‐harm following prescription of SSRIs and other antidepressants: confounding by indication. British journal of clinical pharmacology, 60(5), 519-525.