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* The solution is now safe to add drop-wise (2.5mg etizolam per drop) to candy, such as pez.
* The solution is now safe to add drop-wise (2.5mg etizolam per drop) to candy, such as pez.
* Allow candy to dry overnight and you'll find it has not changed the form of the candy or caused the sugar to "melt."
* Allow candy to dry overnight and you'll find it has not changed the form of the candy or caused the sugar to "melt."
* Note: if the sugar did "melt," the candy is still safe to consume (though appears rather ugly). In simple terms, the excess HCL has turned your sugar (sucrose) into "smaller sugars" or component saccharides (glucose and fructose).
* Note 2: DO NOT USE OTHER ACIDS FOR THIS PROCEDURE. Nitric acid, for example, will give off dangerous gasses when mixed with isopropanol.
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Etizolam (also known as Etilaam, Etizest, and many others) is a novel depressant substance of the thienodiazepine class. Etizolam is chemically related to benzodiazepines and acts by binding to GABA receptors in the brain.
Etizolam is not commonly prescribed. It has been sold as a research chemical online and is commonly used as a substitute for pharmaceutical benzodiazepines like alprazolam (Xanax) or diazepam (Valium). Etizolam is commonly found in pellet or pill form, laid on blotter paper, or as a pure powder.
Users should note that that as with benzodiazepines, the sudden discontinuation of thienodiazepines can be dangerous or even life-threatening for long-term or heavy users. As a result, individuals who are physically dependent on this substance are advised to taper their dose by gradually lowering the amount taken each day over a prolonged period of time instead of stopping use abruptly.[2]
Due to its high abuse and addiction potential, it is highly advised to use proper harm reduction practices if using this substance.
As a result, it may contain incomplete or wrong information. You can help by expanding it.
Etizolam first appeared on the online research chemical market in 2011. Since then its popularity has steadily increased. This likely owes itself to both its low cost and its abundance, and the highly dependence-forming and addictive nature that it shares with recreationally-used benzodiazepines.[3]
Etizolam differs from most other research chemicals in that it is approved and actively prescribed as a medical treatment for anxiety in many countries around the world, commonly under brand names like Etilaam and Etizest. Its origins as a medical drug are unclear, although medical papers citing its use in the treatment of anxiety have been documented as early as the 1990s.[4]
Chemistry
Etizolam is a structural relative of benzodiazepines, whereby the benzene ring has been replaced by a thiophene ring, classifying it as a thienodiazepine. Thiophene is a five membered aromatic ring with one sulfur atom. Etizolam contains a thiophene ring fused to a diazepine ring, which is a seven membered ring with the two nitrogen constituents located at R1 and R4. This forms the thienodiazepine core of etizolam. An ethyl chain is bound to this bicyclic structure at R7. Additionally, a R2' chlorine-substituted phenyl ring is bound to this structure at R5.
Etizolam also contains a methylated triazole ring fused to and incorporating R1 and R2 of its diazepine ring. Etizolam shares this fused triazole ring substitution with certain benzodiazepine drugs, called triazolobenzodiazepines, distinguished by the suffix "-zolam".
Pharmacology
Thienodiazepines produce a variety of effects by binding to the benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors.[5] As this site is the most prolific inhibitory receptor set within the brain, its modulation results in the sedating (or calming effects) of etizolam on the nervous system.
Subjective effects
Anecdotal reports suggest that in terms of its relative potency, 1 mg of etizolam is approximately equivalent to 0.5 mg of alprazolam (Xanax), 0.5 mg of clonazepam (Klonopin), or 10 mg of diazepam (Valium). It is often compared to a less potent and sedating version of alprazolam in terms of the speed of its onset, total duration, and recreational effect.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
Sedation - Etizolam is sedating in a rapid-acting fashion. At higher doses, this can lead users to suddenly feel as if they are extremely sleep deprived and have not slept for days, forcing them to sit down and generally feel as if they are constantly on the verge of passing out instead of engaging in physical activities. This sense of sleep deprivation increases proportional to dosage and eventually becomes powerful enough to force a person into complete unconsciousness.
Muscle relaxation This effect can be described as similar to diazepam, albeit mild-moderately less prominent depending on the dose. Low doses around 0.5-1mg typically cause an effect comparable to alprazolam.
Appetite enhancement - This effect is not particularly prominent, but is reported to occur in some people. It can have a synergistic effect when combined with cannabis.
Paradoxical reactions to benzodiazepines such as increased seizures (in epileptics), aggression, increased anxiety, violent behavior, loss of impulse control, irritability and suicidal behavior sometimes occur (although they are rare in the general population, with an incidence rate below 1%).[6][7] These paradoxical effects occur with greater frequency in recreational abusers, individuals with mental disorders, children, and patients on high-dosage regimes.[8][9] Although not formally studied, thienodiazepines are assumed to share this risk.
Cognitive euphoria - This effect is generally produced only at high doses, and is thought to arise largely from the release of pre-existing anxiety in the user. Many users report not feeling any pleasurable or euphoric sensations from benzodiazepines or thienodiazepines like etizolam at all.
Compulsive redosing - Compulsive redosing likely occurs due to the rapid way in which the substance produces its anxiety-relieving, relaxing and sometimes euphoric effects before quickly dropping off. It can be made worse due to the memory suppression it produces which can lead the user forgetting they have taken any at all, which can lead to a cycle that leads to a dangerous amnesic blackout state.
Delusions of sobriety - This is the false belief that one is perfectly sober despite obvious evidence to the contrary such as severe cognitive impairment and an inability to fully communicate with others. It most commonly occurs at high to heavy dosages.
Emotion suppression - Although this compound primarily suppresses anxiety, it also dulls other emotions in a manner which is distinct but less intensive than that of antipsychotics.
Rebound anxiety - Rebound anxiety is a commonly observed effect with anxiety relieving substances like benzodiazepines and etizolam. It typically corresponds to the total duration spent under the substance's influence along with the total amount consumed in a given period, an effect which can easily lend itself to cycles of dependence and addiction.
Residual sleepiness - While etizolam can be used as an effective sleep-inducing aid, its effects may persist into the morning afterwards, which may lead users to feeling "groggy" or "dull" for up to a few hours.
Many people put Etizolam on to candy or blotters to dose it more safely. However, most people find that it is not easily soluble in most expected non-polar solvents; eve 99 percent isopropanol has a solubility of around 1mg/ml, which is less than ideal for dropping onto small candies such as pez.
It is possible to get the solubility up to around 1mg/drop is isopropanol (as a standard drop, being 20 drops per ml), with a the addition of HCL. For example:
250mg etizolam is added to 5ml 99 percent isopropanol in a (preferably standing) test tube.
The solution is placed in a beaker, in a warm water bath (hot tap water will suffice).
HCL (I used 36%, though lower percents will work) is added drop-wise. The total amount added will be in the range of 10-20 drops. Add a few drops, stir, wait, and stir some more. You don't want to use extra HCL as that will acidify the end solution and cause the sugar on your candy to appear glossy/as if wet by water.
Patience is key here; don't use too much HCL. Add it slowly, stir, and wait.
The solution will eventually achieve a yellow tint, and all etizolam particles will dissolve.
You can now test with PH (99% iso should have neutral PH of 7; if you're off, you added too much HCL).
The solution is now safe to add drop-wise (2.5mg etizolam per drop) to candy, such as pez.
Allow candy to dry overnight and you'll find it has not changed the form of the candy or caused the sugar to "melt."
Note: if the sugar did "melt," the candy is still safe to consume (though appears rather ugly). In simple terms, the excess HCL has turned your sugar (sucrose) into "smaller sugars" or component saccharides (glucose and fructose).
Note 2: DO NOT USE OTHER ACIDS FOR THIS PROCEDURE. Nitric acid, for example, will give off dangerous gasses when mixed with isopropanol.
Experience reports
There are currently anecdotal reports which describe the effects of this compound within our experience index.
Etizolam likely has a low toxicity relative to dose.[12] However, it is [[Toxicity::potentially lethal when mixed with depressants like alcohol or opioids]].
Like most benzodiazepines, etizolam is considered to be highly addictive with a high potential for abuse.
In one study in which multiple doses of either etizolam or lorazepam were administered to rat neurons, tolerance to the anticonvulsant effects of lorazepam but not to etizolam was observed.[13] Etizolam therefore has a reduced liability to induce tolerance, and dependence when compared with classic benzodiazepines.[13]
Tolerance will, however, develop to the sedative-hypnotic effects within a couple of days of continuous use. After cessation, the tolerance returns to baseline in 7 - 14 days. However, in certain cases this may take significantly longer in a manner which is proportional to the duration and intensity of one's long-term usage.
Thienodiazepine discontinuation is notoriously difficult and potentially life-threatening for heavy or long-term users. There is an increased risk of seizure following discontinuation of thienodiazepines. Withdrawal symptoms or rebound symptoms may occur after ceasing usage abruptly following a few weeks or longer of steady dosing, and may necessitate a gradual dose reduction. For more information on tapering from thienodiazepines in a controlled manner, please see this guide. Substances which lower the seizure threshold such as tramadol should be avoided during withdrawal.
Etizolam presents cross-tolerance with [[Cross-tolerance::all benzodiazepines and thienodiazepines]], meaning that after its consumption all benzo and thienodiazepines will have a reduced effect.
Overdose
Thienodiazepine overdose may occur when taken in extremely heavy quantities or concurrently with other depressants.
This is particularly dangerous with other GABAergic depressants such as barbiturates and alcohol since they work in a similar fashion, but bind to distinct allosteric sites on the GABAA receptor, thus their effects potentiate one another.
Thienodiazepine increase the frequency in which the chlorine ion pore opens on the GABAA receptor while barbiturates increase the duration in which they are open, meaning when both are consumed, the ion pore will open more frequently and stay open longer[14].
Thienodiazepine overdose is a medical emergency that may lead to a coma, permanent brain injury or death if not treated promptly and properly.
Symptoms of a thienodiazepine overdose may include severe thought deceleration, slurred speech, confusion, delusions, respiratory depression, coma or death.
Thienodiazepine overdoses may be treated effectively in a hospital environment, with generally favorable outcomes.
Thienodiazepine overdoses are sometimes treated with flumazenil, a GABAA antagonist[15]. However, care is primarily supportive in nature.
Dangerous interactions
Warning:Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
Dissociatives - This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.
Stimulants - It is dangerous to combine thienzodiazepines with stimulants due to the risk of excessive intoxication. Stimulants mask the sedative effect of thienzodiazepines, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of thienzodiazepines will be significantly increased, leading to intensified disinhibition. If combined, one should strictly limit themselves to only dose a certain amount of thienzodiazepines per hour. This combination can also potentially result in severe dehydration if hydration is not monitored.
Legal status
Canada: Etizolam is not a scheduled substance in Canada, although it is only legal to import for research purposes.[citation needed]
Germany: Etizolam is a controlled substance in Germany.[16][17]
Poland: Etizolam may be scheduled under the Act on Counteracting Drug Addiction and the State Sanitary Inspection - Article 27c.[citation needed]
Switzerland: Etizolam is a controlled substance Switzerland.[18]
United Kingdom: Etizolam is a Class C substance in the UK as of May 31st, 2017, making it illegal to possess, produce, or supply.[19]
United States: Etizolam is not a scheduled substance in the United States.
Arkansas: In August 2014, the state of Arkansas listed etizolam as a Schedule I substance under its substance scheduling guidelines.[20]
North Carolina: On March 22, 2017, the General Assembly of North Carolina enacted an addendum to the North Carolina Controlled Substances Act including etizolam as a Schedule I substance.
Texas On Jun 9, 2017, the state of Texas listed etizolam as a Penalty Group 3 substance with HB 2671.[21] Contrary to some online reports and conflicting information with the overall Texas controlled substance list website, etizolam became a penalty group 3 substance with the passage of this bill.
Sanna, E., Pau, D., Tuveri, F., Massa, F., Maciocco, E., Acquas, C., ... & Biggio, G. (1999). Molecular and neurochemical evaluation of the effects of etizolam on GABAA receptors under normal and stress conditions. Arzneimittelforschung, 49(02), 88-95. https://doi.org/10.1055/s-0031-1300366
Altamura, A. C., Moliterno, D., Paletta, S., Maffini, M., Mauri, M. C., & Bareggi, S. (2013). Understanding the pharmacokinetics of anxiolytic drugs. Expert Opinion on Drug Metabolism & Toxicology, 9(4), 423-440. https://doi.org/10.1517/17425255.2013.759209
Fracasso, C., Confalonieri, S., Garattini, S., & Caccia, S. (1991). Single and multiple dose pharmacokinetics of etizolam in healthy subjects. European Journal of Clinical Pharmacology, 40(2), 181-185. https://doi.org/10.1007/BF00280074
↑Sanna, E., Pau, D., Tuveri, F., Massa, F., Maciocco, E., Acquas, C., ... & Biggio, G. (1999). Molecular and neurochemical evaluation of the effects of etizolam on GABAA receptors under normal and stress conditions. Arzneimittelforschung, 49(02), 88-95. https://doi.org/10.1055/s-0031-1300366
