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>David Hedlund <ref>{{ cite book | author = Massaro, E. J. | title = Handbook of Neurotoxicology | publisher = Humana Press | location = Totowa, NJ | year = 2002 | isbn = 0-89603-796-7 | url = https://books.google.com/books?id=2c2K-epbCDQC&pg=PA237&lpg=PA237&dq=harmalin |
>David Hedlund Added Curcumin |
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* [[Harmaline]]<ref>{{ cite book | author = Massaro, E. J. | title = Handbook of Neurotoxicology | publisher = Humana Press | location = Totowa, NJ | year = 2002 | isbn = 0-89603-796-7 | url = https://books.google.com/books?id=2c2K-epbCDQC&pg=PA237&lpg=PA237&dq=harmaline+antidepressant | page = 237 }}</ref> found in [[Peganum harmala (botany)|Syrian rue (''Peganum harmala'')]] | * [[Harmaline]]<ref>{{ cite book | author = Massaro, E. J. | title = Handbook of Neurotoxicology | publisher = Humana Press | location = Totowa, NJ | year = 2002 | isbn = 0-89603-796-7 | url = https://books.google.com/books?id=2c2K-epbCDQC&pg=PA237&lpg=PA237&dq=harmaline+antidepressant | page = 237 }}</ref> found in [[Peganum harmala (botany)|Syrian rue (''Peganum harmala'')]] | ||
* Turmeric (''Curcuma longa''): Curcumin<ref>{{cite journal |last1=Kulkarni |first1=SK |last2=Bhutani |first2=AK |last3=Bishnoi |first3=M. |title=Antidepressant activity of curcumin: involvement of serotonin and dopamine system. |journal=Psychopharmacology |date=3 September 2008 |volume=201 |issue=3 |pages=435–442 |doi=10.1007/s00213-008-1300-y |pmid=18766332 }}</ref><ref>{{cite journal |last1=Kulkarni |first1=S. K. |last2=Dhir |first2=A. |title=An Overview of Curcumin in Neurological Disorders |journal=Indian Journal of Pharmaceutical Sciences |date=March 2010 |volume=72 |issue=2 |pages=149–154 |pmc=2929771 |doi=10.4103/0250-474X.65012 |pmid=20838516}}</ref> (selectivity for MAO-A is disputed<ref>{{cite web |title=Curcumin and the MAO Inhibitor "Cheese Effect" from Tyramine Triggered Hypertension |url=https://emediahealth.com/2012/01/17/curcumin-and-the-mao-inhibitor-cheese-effect-from-tyramine-triggered-hypertension/ |website=EmediaHealth |date=17 January 2012 |accessdate=28 March 2017 |deadurl=no |archiveurl=https://web.archive.org/web/20170330014040/https://emediahealth.com/2012/01/17/curcumin-and-the-mao-inhibitor-cheese-effect-from-tyramine-triggered-hypertension/ |archivedate=30 March 2017 |df=dmy-all }}</ref>). Curcumin is commonly sold with piperine that enhances the effect of MAO inhibition. | |||
===Pharmaceuticals=== | ===Pharmaceuticals=== | ||
Revision as of 03:55, 26 October 2018
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This article is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it. |
Reversible inhibitors of monoamine oxidase A (RIMAs) are a class of drugs which selectively and reversibly inhibit the enzyme monoamine oxidase A (MAO-A). They are used clinically in the treatment of depression and dysthymia, though they have not gained widespread market share due to limited efficacy relative to other antidepressants. Because of their reversibility and selectivity, RIMAs are safer than the older monoamine oxidase inhibitors (MAOIs).[1]
While safer than general MAOIs, RIMAs still have highly dangerous and sometimes fatal interactions with many common drugs; in particular, they can cause serotonin syndrome or hypertensive crisis when combined with almost any antidepressant or stimulant, common migraine medications, certain herbs, or even most cold medicines (including decongestants, antihistamines, and cough syrup).
Examples
See also: MAOI § Examples
- Harmaline[2] found in Syrian rue (Peganum harmala)
- Turmeric (Curcuma longa): Curcumin[3][4] (selectivity for MAO-A is disputed[5]). Curcumin is commonly sold with piperine that enhances the effect of MAO inhibition.
Pharmaceuticals
- Moclobemide (commonly known by the trade names Amira, Aurorix, Clobemix , Depnil and Manerix)
References
- ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833271/
- ↑ Massaro, E. J. (2002). Handbook of Neurotoxicology. Totowa, NJ: Humana Press. p. 237. ISBN 0-89603-796-7.
- ↑ Kulkarni, SK; Bhutani, AK; Bishnoi, M. (3 September 2008). "Antidepressant activity of curcumin: involvement of serotonin and dopamine system". Psychopharmacology. 201 (3): 435–442. doi:10.1007/s00213-008-1300-y. PMID 18766332.
- ↑ Kulkarni, S. K.; Dhir, A. (March 2010). "An Overview of Curcumin in Neurological Disorders". Indian Journal of Pharmaceutical Sciences. 72 (2): 149–154. doi:10.4103/0250-474X.65012. PMC 2929771
. PMID 20838516.
- ↑ "Curcumin and the MAO Inhibitor "Cheese Effect" from Tyramine Triggered Hypertension". EmediaHealth. 17 January 2012. Archived from the original on 30 March 2017. Retrieved 28 March 2017.