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'''N,N-Dipropyltryptamine''' (also known as '''Dipropyltryptamine''', '''DPT''', and '''"The Light"''') is a synthetic [[psychoactive class::psychedelic]] of the [[chemical class::tryptamine]] chemical class that produces powerful, short-lived visionary [[psychedelic]] effects similar to, but often considered to be more unpredictable and "challenging," than those of [[DMT]] when [[Routes of administration|administered]]. It is a structural homolog of [[DMT]] that is often reported to be uniquely similar in its [[hallucinogenic]] intensity, albeit with a moderately longer duration and a tendency to feel more "bizarre" and "chaotic", if not "unsettling", relative to DMT and other psychedelic [[tryptamines]].
'''N,N-Dipropyltryptamine''' (also known as '''Dipropyltryptamine''', '''DPT''', and '''"The Light"''') is a synthetic [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] class that produces DMT-like visionary [[psychedelic]] effects when [[administered]]. It is closely related to [[DMT]] and is reported to be uniquely similar in its hallucinogenic intensity, albeit with a moderately longer duration and greater unpredictability relative to DMT and other psychedelic tryptamines.
DPT was first reported in 1973, where it was researched in low doses as an adjunct to therapy for alcoholism.<ref>Grof, S., Soskin, R. A., Richards, W. A., & Kurland, A. A. (1972). DPT as an adjunct in psychotherapy of alcoholics. ''International Pharmacopsychiatry'', 8(1), 104-115. PMID: 4150711</ref> It has also been researched in high doses to induce peak experiences for terminal cancer patients.<ref>Richards, W. A., Rhead, J. C., DiLeo, F. B., Yensen, R., & Kurland, A. A. (1977). The peak experience variable in DPT-assisted psychotherapy with cancer patients. ''Journal of Psychedelic Drugs'', 9(1), 1-10. http://dx.doi.org/10.1080/02791072.1977.10472020</ref> It has gained some notoriety for its adoption as the primary sacrament for the "Temple of the True Inner Light" in the United States, a Christian off-shoot organization who believe in the ritual use of [[psychedelics]] and refer to them as "the true flesh of God."<ref>Temple of the True Inner Light | http://psychede.tripod.com/</ref>
DPT use was first reported in 1973, where it was researched in low doses as an adjunct to therapy for alcoholism.<ref>Grof, S., Soskin, R. A., Richards, W. A., & Kurland, A. A. (1972). DPT as an adjunct in psychotherapy of alcoholics. ''International Pharmacopsychiatry'', 8(1), 104-115. PMID: 4150711</ref> It has also been researched in high doses to induce peak experiences for terminal cancer patients.<ref>Richards, W. A., Rhead, J. C., DiLeo, F. B., Yensen, R., & Kurland, A. A. (1977). The peak experience variable in DPT-assisted psychotherapy with cancer patients. ''Journal of Psychedelic Drugs'', 9(1), 1-10. http://dx.doi.org/10.1080/02791072.1977.10472020</ref> It has gained some notoriety for its adoption as the primary sacrament for the "Temple of the True Inner Light" in the United States, a Christian off-shoot organization who believe in the ritual use of [[psychedelics]] and refer to them as "the true flesh of God."<ref>Temple of the True Inner Light | http://psychede.tripod.com/</ref>
DPT is commonly consumed via [[insufflation]] or [[orally]]. Many report the experience of insufflation to be very congestive and painful which, with the rapidness of onset, does not give the user much time to acclimate themselves to its powerful effects. It can also be administered [[intramuscular|intramuscularly]] or via [[vaporization]] after conversion to the freebase form, and this appears to be the preferred [[Routes of administration|route of administration]] in research settings. Smoking the freebase is reported to be the preferred route used by the "Temple of True Inner Light".{{citation needed}}
DPT is commonly consumed via [[insufflation]] or [[orally]]. Many report the experience of insufflation to be very congestive and painful which, with the rapidness of onset, does not give the user much time to acclimate themselves to its powerful effects. It can also be administered [[intramuscular|intramuscularly]] or via [[vaporization]] after conversion to the freebase form, and this appears to be the preferred [[Routes of administration|route of administration]] in research settings. Smoking the freebase is reported to be the preferred route used by the "Temple of True Inner Light".{{citation needed}}
Very little data exists about the pharmacological properties, metabolism, and toxicity of DPT, and it has relatively little history of human usage. It has long been available on the [[research chemicals]] market as a legal, grey-market alternative to [[DMT]], and commercially distributed through online vendors. Many reports also suggest that this substance may be overly difficult to use safely for those who are not already very experienced with [[hallucinogens]]. Therefore it is highly advised to approach this unusually powerful [[psychedelic]] substance with the proper amount of precaution and [[Responsible drug use#Hallucinogens|harm reduction practices]] if one chooses to use it.
Very little data exists about the pharmacological properties, metabolism, and toxicity of DPT, and it has relatively little history of human usage. It has long been available on the [[research chemicals]] market as a legal, grey-market alternative to [[DMT]], and commercially distributed through online vendors. Many reports also suggest that this substance may be overly difficult to use safely for those who are not already very experienced with [[hallucinogens]]. It is highly advised to approach this powerful [[psychedelic]] substance with the proper amount of precaution and [[Responsible drug use#Hallucinogens|harm reduction practices]] when using it.
==History and culture==
{{historyStub}}
==Chemistry==
==Chemistry==
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==Pharmacology==
==Pharmacology==
{{pharmacology}}
{{Further|Serotonergic psychedelic}}
{{Further|Serotonergic psychedelic}}
DPT's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub>]] and [[Serotonin#The 5-HT system|5-HT<sub>1A</sub>]] [[receptor]] as a [[Agonist#Agonists|partial agonist]].<ref>William E. Fantegrossi, Chad J. Reissig, Elyse B. Katz, Haley L. Yarosh, Kenner C. Rice, Jerrold C. Winterb. Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents. Pharmacol Biochem Behav. 2008 January; 88(3): 358–365.</ref>
DPT's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub>]] and [[Serotonin#The 5-HT system|5-HT<sub>1A</sub>]] [[receptor]] as a [[Agonist#Agonists|partial agonist]].<ref>William E. Fantegrossi, Chad J. Reissig, Elyse B. Katz, Haley L. Yarosh, Kenner C. Rice, Jerrold C. Winterb. Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents. Pharmacol Biochem Behav. 2008 January; 88(3): 358–365.</ref>
The role of these interactions and how they result in the [[psychedelic]] experience continues to remain subject to ongoing scientific investigation.
The role of these interactions and how they result in the [[psychedelic]] experience remains the subject of ongoing scientific investigation.
==Subjective effects==
==Subjective effects==
{{effectStub}}
Relative to psychedelic tryptamines like DMT, DPT is often reported to be similar in its [[hallucinogenic]] intensity, albeit with a moderately longer duration and more challenging effects. DPT experiences are often described as a "bizarre", "unsettling", and "darker" version of DMT experiences. DPT is reported to be more sensual and physical than DMT and other psychedelics with a corresponding amount of adverse physical effects.
At light to moderate doses, users often report a slight sense of anaesthetization and relaxation. As the dose increases, hyper-awareness of one's heart rate and breathing increases and body tremors and loss of muscle control are often reported. The effects of DPT can range from strong euphoria and sensuality to nausea, panic, and intense states dysphoria even within the same experience.
At light to moderate doses, users often report a slight sense of anaesthetization and relaxation. As the dose increases, hyper-awareness of one's heart rate and breathing increases and body tremors and loss of muscle control are often reported. The effects of DPT can range from strong euphoria and sensuality to nausea, panic, and intense states dysphoria even within the same experience.
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*'''[[Effect::Excessive yawning]]'''
*'''[[Effect::Excessive yawning]]'''
*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Increased libido]]'''- This effect appears to occur with more regularity and intensity than other psychedelic tryptamines.
*'''[[Effect::Increased libido]]''' - This effect appears to occur with more regularity and intensity than other psychedelic tryptamines.
}}
}}
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====[[Effect::Geometry]]====
====[[Effect::Geometry]]====
The visual geometry of DPT can be described through its variations as intricate in complexity, both abstract and concrete in form, more digital than organic in feel, choppy and only loosely structured in organization, brightly lit, multicolored in scheme, sharp in its edges, fast in speed, simultaneously smooth and glitching in motion, immersive in depth, and consistent in intensity. At higher doses, it is more likely to result in states of [[Effect::8A Geometry|level 8A geometry]] over level 8B.
DPT visual geometry can be described through its variations as intricate in complexity, both abstract and concrete in form, more digital than organic in feel, choppy and only loosely structured in organization, brightly lit, multicolored in scheme, sharp in its edges, fast in speed, simultaneously smooth and glitching in motion, immersive in depth, and consistent in intensity. At higher doses, it is more likely to result in states of [[Effect::8A Geometry|level 8A geometry]] over level 8B.
====Hallucinatory states====
====Hallucinatory states====
DPT produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of any other commonly used psychedelic barring [[DMT]] and [[Ibogaine]]. These effects include:
DPT produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of any other commonly used psychedelic barring [[DMT]] and [[ibogaine]]. These effects include:
*'''[[Effect::Transformations]]'''
*'''[[Effect::Transformations]]'''
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==Toxicity and harm potential==
==Toxicity and harm potential==
{{toxicity}}
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
The toxicity and long-term health effects of recreational DPT do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because DPT is a [[research chemical]] with very little history of human usage.
The toxicity and long-term health effects of recreational DPT do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because DPT is a [[research chemical]] with very little history of human usage.
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
N,N-Dipropyltryptamine (also known as Dipropyltryptamine, DPT, and "The Light") is a synthetic psychedelic substance of the tryptamine class that produces DMT-like visionary psychedelic effects when administered. It is closely related to DMT and is reported to be uniquely similar in its hallucinogenic intensity, albeit with a moderately longer duration and greater unpredictability relative to DMT and other psychedelic tryptamines.
DPT use was first reported in 1973, where it was researched in low doses as an adjunct to therapy for alcoholism.[1] It has also been researched in high doses to induce peak experiences for terminal cancer patients.[2] It has gained some notoriety for its adoption as the primary sacrament for the "Temple of the True Inner Light" in the United States, a Christian off-shoot organization who believe in the ritual use of psychedelics and refer to them as "the true flesh of God."[3]
DPT is commonly consumed via insufflation or orally. Many report the experience of insufflation to be very congestive and painful which, with the rapidness of onset, does not give the user much time to acclimate themselves to its powerful effects. It can also be administered intramuscularly or via vaporization after conversion to the freebase form, and this appears to be the preferred route of administration in research settings. Smoking the freebase is reported to be the preferred route used by the "Temple of True Inner Light".[citation needed]
Very little data exists about the pharmacological properties, metabolism, and toxicity of DPT, and it has relatively little history of human usage. It has long been available on the research chemicals market as a legal, grey-market alternative to DMT, and commercially distributed through online vendors. Many reports also suggest that this substance may be overly difficult to use safely for those who are not already very experienced with hallucinogens. It is highly advised to approach this powerful psychedelic substance with the proper amount of precaution and harm reduction practices when using it.
DPT, or N,N-dipropyltryptamine, is a synthetic indole molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain. DPT contains two propyl groups carbon chains bound to the terminal amine RN of its tryptamine backbone.
DPT has a number of substituted analogs such as 4-HO-DPT or 4-AcO-DPT.
The role of these interactions and how they result in the psychedelic experience remains the subject of ongoing scientific investigation.
Subjective effects
Relative to psychedelic tryptamines like DMT, DPT is often reported to be similar in its hallucinogenic intensity, albeit with a moderately longer duration and more challenging effects. DPT experiences are often described as a "bizarre", "unsettling", and "darker" version of DMT experiences. DPT is reported to be more sensual and physical than DMT and other psychedelics with a corresponding amount of adverse physical effects.
At light to moderate doses, users often report a slight sense of anaesthetization and relaxation. As the dose increases, hyper-awareness of one's heart rate and breathing increases and body tremors and loss of muscle control are often reported. The effects of DPT can range from strong euphoria and sensuality to nausea, panic, and intense states dysphoria even within the same experience.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
Spontaneous bodily sensations - The "body high" of DPT is generally more prominent to that of the better known DMT. There is often the sensation of limbs feeling disconnected from the body, a force pinning the body to the surface on which it lay and body tremors which can often make the user feel aware of but not in control of their body.
DPT visual geometry can be described through its variations as intricate in complexity, both abstract and concrete in form, more digital than organic in feel, choppy and only loosely structured in organization, brightly lit, multicolored in scheme, sharp in its edges, fast in speed, simultaneously smooth and glitching in motion, immersive in depth, and consistent in intensity. At higher doses, it is more likely to result in states of level 8A geometry over level 8B.
Hallucinatory states
DPT produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of any other commonly used psychedelic barring DMT and ibogaine. These effects include:
Machinescapes - These are reported to be more common with DPT than with DMT, which lends to its common description as feeling more "industrial" and futuristic, while DMT visuals can often be described as "ancient" or "earthy" in feel.
Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - As with DMT, DPT produces high level internal hallucinations at appropriate doses more consistently than most other psychedelics. They are more common within dark environments and can be comprehensively described through their variations as lucid in believability, interactive in style, new experiences in content, non-autonomous in controllability, geometry-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental narrative in their overall theme, with a tendency towards chaotic disorganization and incoherence.
External hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - These are more common within dark environments and can be comprehensively described through their variations as lucid in believability, interactive in style, new experiences in content, non-autonomous in controllability, geometry-based in style and typically of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental narrative in their overall theme, with a tendency towards chaotic disorganization and incoherence.
Synaesthesia - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states.
Many reports indicate that while DPT possesses the raw hallucinogenic power to induce transpersonal states traditionally associated with "classical psychedelics", it does so in a significantly less consistent fashion due to the utter bizarreness and oft-noted "sinister", chaotic, or "forceful" undertones that can be present throughout the experience. What insights it can lead the user to typically occur during the aftermath and integration phase that follows, which shares some qualities of a typical near-death experience.
This toxicity and harm potential section is a stub.
As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.
The toxicity and long-term health effects of recreational DPT do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because DPT is a research chemical with very little history of human usage.
Anecdotal reports from those who have taken DPT suggests that there negative health effects are not likely to occur from simply trying it by itself at low to moderate doses and using it very sparingly (although nothing can be guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
DPT is not habit-forming and the desire to use it can actually decrease with use. As with most psychedelics, it is reported to be self-limiting.
Tolerance to the effects of DPT have been shown to not be built in animal models.[5] However, it has been reported to be able to build slightly relative to DMT, although still to an insignificant degree compared to most psychedelics.
Dangerous interactions
Warning:Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
Tramadol - Tramadol lowers the seizure threshold[6] and psychedelics may act as triggers for seizures, particularly in those who are predisposed to them.[citation needed]
Stimulants - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable anxiety, panic, thought loops and paranoia. This interaction may cause elevated risk of psychosis.[citation needed]
Lithium - Lithium is often used as treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its glutaminergic and GABAergic effects.[citation needed]
New Zealand: DPT is an analogue of DMT, so is a Class C controlled drug in New Zealand.[8]
Sweden: Following its sale as a designer drug, DPT was made illegal in Sweden on 26 January 2016.[9]
United Kingdom: DPT is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.[10]
United States: DPT is unscheduled in the United States. It may be considered an analogue of DET, a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.[citation needed] DPT is a Schedule I controlled substance in the states of Florida, Maine, and Oklahoma making it illegal to buy, sell, or possess.[11][12]
Soskin, R.A., Grof, S., & Richards, W.A. (1973). Low doses of Dipropyltryptamine in psychotherapy. Archives of General Psychiatry, 28 6, 817-21.
Richards, W. A., Rhead, J. C., DiLeo, F. B., Yensen, R., & Kurland, A. A. (1977). The peak experience variable in DPT-assisted psychotherapy with cancer patients. Journal of Psychedelic Drugs, 9(1), 1-10. http://dx.doi.org/10.1080/02791072.1977.10472020
Grof, S., Soskin, R. A., Richards, W. A., & Kurland, A. A. (1972). DPT as an adjunct in psychotherapy of alcoholics. International Pharmacopsychiatry, 8(1), 104-115. PMID: 4150711
Li, J., Rice, K.C., & France, C.P. (2007). Behavioral effects of dipropyltryptamine in rats: evidence for 5-HT1A and 5-HT2A agonist activity. Behavioural Pharmacology, 18 4, 283-8.
References
↑Grof, S., Soskin, R. A., Richards, W. A., & Kurland, A. A. (1972). DPT as an adjunct in psychotherapy of alcoholics. International Pharmacopsychiatry, 8(1), 104-115. PMID: 4150711
↑Richards, W. A., Rhead, J. C., DiLeo, F. B., Yensen, R., & Kurland, A. A. (1977). The peak experience variable in DPT-assisted psychotherapy with cancer patients. Journal of Psychedelic Drugs, 9(1), 1-10. http://dx.doi.org/10.1080/02791072.1977.10472020
↑William E. Fantegrossi, Chad J. Reissig, Elyse B. Katz, Haley L. Yarosh, Kenner C. Rice, Jerrold C. Winterb. Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents. Pharmacol Biochem Behav. 2008 January; 88(3): 358–365.
↑Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089
↑Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (Triptamīni) | http://likumi.lv/doc.php?id=121086
