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Psilocybin mushroom lemon tek: Difference between revisions

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Inaccuracies- while there's no specific literature supporting the use of lemon juice to dephosphorylate psilocybin, it's inaccurate to say the dephosphorlyation process is exclusive to the alkaline phosphatase enzyme.
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The Psilocybin in magic mushrooms is a prodrug to psilocin, the psychoactive compound that causes the effects. Once the mushrooms reach the stomach, this conversion process begins. This is why psilocybin mushrooms often take an hour or so to kick in. The lemon tek theory suggests the acid in the lemon juice jump starts the conversion of psilocybin into psilocin. This is incorrect because the conversion process from psilocybin into psilocin is done by an enzyme called Alkaline Phosphatase. This enzyme is produced in vivo <ref>Zamnesia Lemon Tek Recipe - https://www.zamnesia.com/blog-the-lemon-tek-for-a-faster-trip-n232</ref> - and particularly concentrated in the liver, bile duct, and kidneys <ref>The enzymic dephosphorylation and oxidation of psilocybin and pscilocin by mammalian tissue homogenates - http://www.sciencedirect.com/science/article/pii/0006295261901241</ref>. This conversion process is called dephosphorylation, and can not be done with a lemon <ref>Hallucinogenic mushrooms drug profile - http://www.emcdda.europa.eu/publications/drug-profiles/mushrooms</ref>.
The psilocybin in magic mushrooms is a prodrug to psilocin, the psychoactive compound that causes the effects. Once the mushrooms reach the stomach, the conversion process, known as dephosphorylation, begins. This is why psilocybin mushrooms often take an hour or so to kick in. The lemon tek theory suggests the acid in the lemon juice jump starts the conversion of psilocybin into psilocin. There are two processes by which psilocybin can be dephosphorylated <ref>Hallucinogenic mushrooms drug profile - http://www.emcdda.europa.eu/publications/drug-profiles/mushrooms</ref> into psilocin- either via the alkaline phosphatase enzyme in the intestine and kidney, or in acidic environments like the stomach.<ref>Ricardo Jorge Dinis-Oliveira (2017) [https://doi.org/10.1080/03602532.2016.1278228 Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance], Drug Metabolism Reviews, 49:1, 84-91,</ref> In theory, lemon juice, which has a pH of around 2, should be acidic enough to dephosphorylate psilocybin in the same way the stomach can (with a pH of 1.5 to 3.5 in humans).<ref>Marieb EN, Hoehn K (2010). Human anatomy & physiology. San Francisco: Benjamin Cummings. ISBN 0-8053-9591-1.</ref> Purported effects include faster onset, a more intense trip, and reduced nausea.<ref>Zamnesia Lemon Tek Recipe -https://www.zamnesia.com/blog-the-lemon-tek-for-a-faster-trip-n232</ref>


== Warning ==
== Warning ==
There is no science to support the lemon tek theory, and the reported subjective benefits may be due to the placebo effect. Despite the lack of concrete evidence which demonstrates the effectiveness of this method, proponents of the tek will recommended that you start at half your regular dose of mushrooms when using this method due to the faster come up and increased potency.
There is no research to support the lemon tek theory specifically, though science does support the concept of acidic environments converting psilocybin into psilocin. Some, if not all the effects may be attributed to placebo effect.


== Materials ==
== Materials ==

Revision as of 22:10, 3 May 2018

Template:Proofread The psilocybin in magic mushrooms is a prodrug to psilocin, the psychoactive compound that causes the effects. Once the mushrooms reach the stomach, the conversion process, known as dephosphorylation, begins. This is why psilocybin mushrooms often take an hour or so to kick in. The lemon tek theory suggests the acid in the lemon juice jump starts the conversion of psilocybin into psilocin. There are two processes by which psilocybin can be dephosphorylated [1] into psilocin- either via the alkaline phosphatase enzyme in the intestine and kidney, or in acidic environments like the stomach.[2] In theory, lemon juice, which has a pH of around 2, should be acidic enough to dephosphorylate psilocybin in the same way the stomach can (with a pH of 1.5 to 3.5 in humans).[3] Purported effects include faster onset, a more intense trip, and reduced nausea.[4]

Warning

There is no research to support the lemon tek theory specifically, though science does support the concept of acidic environments converting psilocybin into psilocin. Some, if not all the effects may be attributed to placebo effect.

Materials

  • Psilocybin Mushrooms
  • Small Glass
  • Fresh Lemon Juice
  • Water

Procedure

  • Grind your mushrooms or truffles into a very fine powder
  • Place this powder into the glass
  • Fill the glass with just enough lemon juice to cover the powder
  • Leave for 20 minutes, and stir every 5. Do not leave for longer than 20 minutes
  • Fill the glass with some water, swirl, making sure to get all bits of the mushroom, and drink

References

  1. Hallucinogenic mushrooms drug profile - http://www.emcdda.europa.eu/publications/drug-profiles/mushrooms
  2. Ricardo Jorge Dinis-Oliveira (2017) Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance, Drug Metabolism Reviews, 49:1, 84-91,
  3. Marieb EN, Hoehn K (2010). Human anatomy & physiology. San Francisco: Benjamin Cummings. ISBN 0-8053-9591-1.
  4. Zamnesia Lemon Tek Recipe -https://www.zamnesia.com/blog-the-lemon-tek-for-a-faster-trip-n232