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Diarylethylamines: Difference between revisions
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[[File:Diarylethylamine.png|250px|thumbnail|The general structure for a diarylethylamine]] | [[File:Diarylethylamine.png|250px|thumbnail|The general structure for a diarylethylamine]] | ||
'''Diarylethylamines''' are [[ | '''Diarylethylamines''' are an individual class of [[dissociatives]], which differ in their chemical structure from others like [[PCP]] or [[ketamine]], but typically produce similar, sometimes unique effects. They are very novel and are [[research chemicals]], which can be bought online. | ||
===Pharmacology=== | ===Pharmacology=== | ||
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===Examples=== | ===Examples=== | ||
* [[Diphenidine]] | * [[Diphenidine]] | ||
* [[Ephenidine]] | * [[Ephenidine]] | ||
* [[Methoxphenidine]] (''MXP'') | * [[Methoxphenidine]] (''MXP'') | ||
==See also== | ==See also== | ||
* [[Responsible use]] | * [[Responsible use]] | ||
* [[Dissociative]] | * [[Dissociative]] | ||
* [[Arylcyclohexylamine]] | * [[Arylcyclohexylamine]] | ||
==References== | ==References== | ||
<references /> | <references /> | ||
Revision as of 19:35, 5 February 2018
 |
This article is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it. |
Diarylethylamines are an individual class of dissociatives, which differ in their chemical structure from others like PCP or ketamine, but typically produce similar, sometimes unique effects. They are very novel and are research chemicals, which can be bought online.
Pharmacology
| Compound | IC50 ± SEM (nM) | Ki ± SEM (nM) |
|---|---|---|
| PCP[2] | 91 ± 1.3 | 57.9 ± 0.8 |
| Ketamine | 508.5 ± 30.1 | 323.9 ± 19.2 |
| Memantine | 594.2 ± 41.3 | 378.4 ± 26.3 |
| (+)-MK-801 | 4.1 ± 1.6 | 2.5 ± 1.0 |
| DPH (Diphenidine) | 28.6 ± 3.5 | 18.2 ± 2.2 |
| 2-MXP (Methoxphenidine) | 56.5 ± 5.8 | 36.0 ± 3.7 |
| 3-MXP | 30.3 ± 2.6 | 19.3 ± 1.7 |
| 4-MXP | 723.8 ± 69.9 | 461.0 ± 44.5 |
| 2-Cl-DPH | 14.6 ± 2.1 | 9.3 ± 1.3 |
| NMDAR binding affinites determined using [3H]-(+)-MK-801 in rat forebrain.[3] | ||