This is an unofficial archive of PsychonautWiki as of 2025-08-11T15:14:44Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
'''3-Hydroxyeticyclidine''' (commonly known as '''3-HO-PCE''') is a novel synthetic [[Psychoactive class::dissociative]] substance of the [[Chemical class::arylcyclohexylamine]] chemical class that produces potent, dose-sensitive [[dissociative]], [[hallucinogenic]] and [[euphoric]] effects when [[Routes of administration|administered]].
I think a lot of the info on 3-ho-pce has been taken from the info for 3-meo-pce, and I do not believe the information to be correct for 3-ho-pce.
Unlike its close structural analog [[3-HO-PCP]], this compound is entirely novel and has no precedent in the scientific literature before being offered on the research chemicals market in the 2010s. Early discussions of this compound have revolved around whether it possesses an appreciable affinity for the mu [[opioid]] receptor given its structural relationship to [[3-HO-PCP]], which is known to possess affinity for the mu opioid receptor.<ref>Kalir, A., S. Maayani, M. Rehavi, R. Elkavetz, I. Pri-Bar, O. Buchman and M. Sokolovsky, 1978, Structure activity relationship of some phencyclidine derivatives; in vivo studies in mice, European J. Med. Chem. 13, 17.</ref>
I do not believe it has a strong mOr activity
Following other substances of its class, particularly [[methoxetamine]] (MXE), [[phencyclidine]] (PCP), and [[3-MeO-PCE]], it is speculated to to be able to induce a state known as "[[dissociatives#Subjective effects|dissociative anesthesia]]". However, the extent to which this is currently unclear.{{citation needed}} Early reports suggest that this state is difficult to reach relative to other [[dissociatives]], and its general effects profile been characterized as "lying halfway between [[3-MeO-PCP]] and [[3-MeO-PCE]]."
I do not believe it will cause mania or psychosis in the average person, even used multiple days in a row. In fact, I believe it to be less psychologically harmful than MXE.
Whether it possesses any of its theorized [[opioid]] activity in humans is the subject of ongoing debated. There are also reports that suggest this compound may produce more physical side effects such as muscle soreness and flu-like symptoms during or shortly after administration. This suggests it may be uniquely more dangerous or toxic than related [[dissociatives]], particularly at higher doses.
regarding dosage. I only have bluelight and [http://drugs.tripsit.me/3-ho-pce tripsit] page to offer, and tripsit is easier to read.
There is a complete lack of data on the pharmacological properties, metabolism, and toxicity of 3-HO-PCE, and it has an extremely brief history of human usage. Today, it is exclusively distributed as a gray area [[research chemical]] by online vendors.<ref>Morris, H., & Wallach, J. (2014). From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs. Drug Testing and Analysis, 6(7–8), 614–632. https://doi.org/10.1002/dta.1620</ref> Due to its potent dissociative and [[opioid]] effects, theorized habit-forming properties, and unknown toxicity profile, it is strongly recommended that one use proper [[harm reduction practices]] if choosing to use this substance.
The info in the tripsit pages doesn't line up well either, so dosage info from there is way off.
==History and culture==
I have only limited research and only a small sample size, but 3-ho-pce seems to be less potent than the tripsit page suggests a strong dose to be 6mg, but in a non-tolerant subject, 3-ho-pce with verified 99.8% purity, it took about 6mg to notice any dissociation. I would like a larger sample size and fewer tolerant people to speak with. In my own experience, even 25mg did not produce any opioid-like feeling. I am, however, somewhat tolerant.
{{historyStub}}
On October 18, 2012 the Advisory Council on the Misuse of Drugs in the United Kingdom released a report about methoxetamine, saying that the "harms of methoxetamine are commensurate with Class B of the Misuse of Drugs Act (1971)", despite the fact that the act does not classify drugs based on harm. The report went on to suggest that all analogues of MXE should also become class B drugs and suggested a catch-all clause covering both existing and unresearched arylcyclohexamines, including 3-HO-PCE.<ref> "(ACMD) Methoxetamine Report (2012)" (PDF). UK Home Office. 2012-10-18. p. 14. Retrieved 2015-06-24.</ref>
the [https://www.bluelight.org/vb/threads/812314-The-Big-amp-Dandy-3-HO-PCE-Thread?p=13958449&viewfull=1#post13958449 Bluelight] thread starting here starts to give some good info. the dosage info I am reading is making more sense than other posts and matching my own research, with the exception of respiratory depression. In my research, pulsox never went below 94% on a non-tolerant user, bp and hr did not seem to be affected in the healthy particpant (only one). Unlike MXE and other PCE analogs, this does not seem to cause an elevated BP afterwards either.
==Chemistry==
3-HO-PCE, or 3-hydroxyphencyclidine, is a synthetic dissociative of the arylcyclohexylamine class. 3-HO-PCE contains cyclohexane, a six-member saturated ring, bonded to two additional rings at R<sub>1</sub>. One of these rings is a piperidine ring, a nitrogenous six member ring, bonded at its nitrogen group. The other ring is an aromatic phenyl ring, substituted at R<sub>3</sub> with a hydroxy group.
Also, most positive, there was an afterglow the next day/after the effects had warn off. But unlike MXE, and 2-Oxo-PCE (especially), the test subject didn't complain of any diminished cognitive effects, where he said o-pce and mxe left him feeling a little bit like he was concussed, dizzy, a little strange to talk with. He said that o-pce was the worst of the three, and he preferred the fewer aftereffects of 3-ho-pce to mxe or o-pce. Again, this is HIS experience and anecdotal report he provided to me in a verbal session. I hope more people can get on to testing this.
We have not done many tests just yet, but I hope to do a lot more.
3-HO-PCE is a [[PCP]] analog and structurally homologous to [[3-MeO-PCP]].
I firmly believe that this is the first true 3-ho-pce on the market, and what was around in 2012-13 was some other, odd (maybe not even an ACH) chem.
==Pharmacology==
{{Further|NMDA receptor antagonist}}
3-HO-PCE acts as an [[NMDA receptor antagonist]]. A specific subtype of glutamate receptor, NMDA (N-Methyl-D-Aspartate), modulates the transmission of electrical signals between neurons in the brain and spinal cord; for the signals to pass, the receptor must be open. Dissociatives inhibit the normal functioning NMDA receptors by binding to and blocking them. This disruption of neural network activity leads to loss of normal cognitive and affective processing, psychomotor functioning, anesthesia.{{citation needed}}
==Subjective effects==
{{effectStub}}
{{Preamble/SubjectiveEffects}}
{{effects/base
:[[User:Lunch-clunge|@Lunchclunge]] Hey there! Thanks for registering on our site. We were initially going to release this one soon after it came out, but decided to wait until we received an independent lab analysis first, as it does not match up to what the SAR predicts. Looking over the bluelight reports, it seems this compound is rather indistinguishable from [[3-MeO-PCP]]/[[3-MeO-PCE]], of which there are plenty of reports that warrant a disclaimer in our view. We were quite concerned about this actually possessing any sort of mOR activity, as it's not like the previous 3-MeO ACH's aren't reinforcing enough on their own! I will try to figure out what to do with this in the meanwhile, please let me know if you become aware of any independent lab analytics on this one. Based on the reports, would not be surprised if this turned out to be good old-fashioned 3-MeO-PCE (and yes I am well aware of the reputation of the vendor). Thank you for your input! :) [[User:Clarity|Clarity]] ([[User talk:Clarity|talk]]) 21:05, 27 April 2017 (CEST)
|{{effects/physical|
::[[User:Clarity|@Clarity]] Who do you use suggest I use for lab analysis? I would love to send some samples of what I have. [[User:Lunch-clunge|Lunchclunge]] Fri, 05:32, 28 April 2017 (Pacific Time)
**'''[[Effect::Perception of decreased weight]]'''
*'''[[Effect::Restless legs]]'''
*'''[[Effect::Spontaneous physical sensations]]''' - The body high of this compound can be described in terms of its style variations as a motionless, constant, sharp, all-encompassing, and euphoric activation of nerve endings across the body.
*'''[[Effect::Physical euphoria]]''' - 3-HO-PCE has been reported to more readily induce euphoria than most other dissociatives, such as [[ketamine]] or [[diphenidine]], especially of the manic variant.
*'''[[Effect::Tactile enhancement]]''' and '''[[Effect::Tactile suppression]]''' - At lower dosages, this compound tends to induce tactile enhancements. At higher dosages, this enhancement shifts towards tactile suppressions and [[pain relief|anesthesia]].
*'''[[Effect::Pain relief]]''' - This substance produces distinct nerve-signal blocking anesthetic effects typically required in surgical settings, but only in the stronger to heavier dose ranges.
*'''[[Effect::Bodily control enhancement]]''' and '''[[Motor control loss]]''' - At lower dosages this compound typically induces enhancements in bodily control. At higher dosages, this enhancement shifts towards motor control
*'''[[Effect::Changes in felt gravity]]'''
*'''[[Effect::Spatial disorientation]]''' - In contrast to other dissociatives like ketamine, this effect is only prominent at high doses.
*'''[[Effect::Abnormal heartbeat]]'''
*'''[[Effect::Increased blood pressure]]'''
*'''[[Effect::Increased heart rate]]'''
*'''[[Effect::Increased perspiration]]'''
*'''[[Effect::Respiratory depression]]'''
*'''[[Effect::Physical autonomy]]'''
*'''[[Effect::Olfactory hallucinations]]
*'''[[Effect::Optical sliding]]'''
*'''[[Effect::Appetite suppression]]'''
*'''[[Effect::Dehydration]]'''
*'''[[Effect::Dizziness]]'''
*'''[[Effect::Difficulty urinating]]'''
*'''[[Effect::Seizure]]''' - This extent to which this effect can be produced is unknown but can likely happen in those predisposed to them, especially while in physically taxing conditions such as being dehydrated, fatigued or undernourished.
:::[[User:Lunch-clunge|@Lunchclunge]] EnergyControl I think is your bet bet. They are based in Spain. Hold on a sec, I'll contact them and see if they have the capabilities for analyzing this one :) [[User:Clarity|Clarity]] ([[User talk:Clarity|talk]]) 23:12, 28 April 2017 (CEST)
}}
{{effects/disconnective|
*'''[[Effect::Tactile disconnection]]'''
*'''[[Effect::Visual disconnection]]''' - This eventually results in 3-HO-PCE's equivalent of the notorious "[https://en.wikipedia.org/wiki/K-hole k-hole]" or, more specifically, ''[[Visual disconnection#Holes, spaces and voids|holes, spaces and voids]]'' alongside of ''[[Visual disconnection#Structures|structures]]''.
*'''[[Effect::Consciousness disconnection]]'''
:::::[[User:Clarity|@Clarity]] are EC and ED really the only ways to go? I would love to start a chem testing business, I just can't get thru the red tape! When I read my countries laws about testing and certification and other concerns, I was appalled by all the bureaucracy and restrictions, so I backed out. Did you know that, if you detect a scheduled chemical in my country, you can't report it's purity? you can only report it was detected, and the total mass of the sample, and then LEO takes that and does their own nonsense calculations on doses? so for instance, if you put 100mu of LSD in 100ml of water, they would say that it is many more doses than it really is. as a testing facility, you cannot report concentration or purity. how crazy is that? I digress... Yes, I know of ec and ed. I guess I will send off samples! ugh... I wish I lived in Wales (not really)[[User:Lunch-clunge|Lunch-clunge]] ([[User talk:Lunch-clunge|talk]]) 17:37, 28 April 2017 (PDT)
}}
|{{effects/cognitive|
*'''[[Effect::Anxiety suppression]]'''
*'''[[Effect::Compulsive redosing]]''' - This effect is more prominent based on the route of administration used. For example, it is especially present when smoked or vaporized, due to the relative abruptness of the substance entering and leaving the bloodstream.
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Creativity enhancement]]'''
*'''[[Effect::Déjà vu]]'''
*'''[[Effect::Mania]]''' - This effect is reportedly more common on 3-HO-PCE than most other dissociatives. It typically occurs during the offset of the trip, but can also occur during the onset and come up as well.
*'''[[Effect::Depersonalization]]'''
*'''[[Effect::Derealization]]'''
*'''[[Effect::Disinhibition]]'''
*'''[[Effect::Psychosis]]''' - This effect has been reported to be more common on 3-HO-PCE than most other dissociatives, such as [[MXE]] or [[Ketamine]]. It typically occurs during the [[offset]] of the trip, but can also occur during the [[onset]] and come up as well.
*'''[[Effect::Delusions]]''' - Like psychosis, this effect is reportedly more common on 3-HO-PCE than most other dissociatives.
*'''[[Effect::Dream potentiation]]'''
*'''[[Effect::Cognitive euphoria]]'''
*'''[[Effect::Memory suppression]]'''
**'''[[Effect::Ego death]]'''
**'''[[Effect::Amnesia]]'''
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Time distortion]]'''
*'''[[Effect::Thought deceleration]]'''
*'''[[Effect::Increased libido]]''' - This is reported to be present at lower dosage ranges.
}}
{{effects/auditory|
*'''[[Effect::Auditory enhancement|Enhancement]]''' - This effect is reported to only occur at lower doses.
*'''[[Effect::Visual acuity enhancement]]''' - This effect has been reported as being especially present at low dosages.
*'''[[Effect::Visual acuity suppression]]''' - While lower doses of this compound tend to produce mild visual acuity enhancements, this effect quickly disappears as one's general visual faculties become suppressed as the dose is increase.
*'''[[Effect::Internal hallucinations]]''' (''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::alterations in perspective]]'' and ''[[effect::scenarios and plots]]'')
}}
}}
===Experience reports===
Anecdotal reports which describe the effects of this compound within our [[experience index]] include:
{{Further|Research chemicals#Toxicity and harm potential}}
The toxicity and long-term health effects of recreational 3-HO-PCE use has not been studied in any scientific context and the exact [[Toxicity::toxic dosage is unknown]]. This is because 3-HO-PCE has a very short history of human usage.
===Tolerance and addiction potential===
The chronic use of 3-HO-PCE can be considered [[Addiction potential::highly addictive with a high potential for adverse side effects such as psychosis]]. In comparison to other [[dissociative]]s, 3-HO-PCE has been reported to be more addictive than [[MXE]], [[diphenidine]], [[ephenidine]], [[DCK]], and [[ketamine]]. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage. There have been multiple reports across the internet of people becoming seriously addicted daily users of this substance so serious precautions and considerations should be taken before trying this substance.
Tolerance to many of the effects of 3-HO-PCE develops [[Time to full tolerance::with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::4 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). 3-HO-PCE presents cross-tolerance with [[Cross-tolerance::all [[dissociative]]s]], meaning that after the consumption of 3-HO-PCE, all [[dissociative]]s will have a reduced effect.
It is strongly recommended that one exercise extreme caution and [[responsible drug use|harm reduction]] practices when using this substance.
*Users should avoid taking the drug multiple days in a row or becoming dependent/addicted to it as this seems to be the main common factor in the observed incidences of severe adverse effects.
*The recommended dosage range should not be exceeded as high doses can trigger these effects as well.
*Users should start with extremely low doses and work their way up as slowly as possible. [[Volumetric liquid dosing|Volumetric liquid dosing]] should preferably be used due to the drug's potency; most standard milligram scales cannot accurately weigh out doses below 10-15mg.<ref>3-HO-PCE (Tripsit) | https://wiki.tripsit.me/wiki/3-HO-PCE</ref>
*[[Compulsive redosing]] before one has fully sobered up is not recommended and can result in too high of a dose.
Due to the risk of psychosis, it is not recommended to combine this drug with other substances, especially [[stimulant]]s, [[psychedelic]]s, or other [[dissociative]]s like [[MXE]]. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
It is strongly recommended that one use [[responsible drug use|harm reduction practices]], such as [[volumetric dosing]], when using this substance to ensure the administration of the intended dose.
===Urinary tract effects===
In terms of its long-term health effects when used repeatedly and excessively for extended periods of time, 3-HO-PCE is likely to exhibit similar bladder and urinary tract problems to those found within [[ketamine]], but to a lesser extent. This is possibly because 3-HO-PCE is far more potent than ketamine so significantly less of drug needs to be consumed. Symptoms of ketamine-induced cystitis can become extremely serious and can be described as:
*'''Urinary frequency''' - Urinary frequency is the need to empty the bladder every few minutes.
*'''Urinary urgency''' - This can be described as a sudden, compelling need to urinate.
*'''Urinary pressure''' - This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination.
*'''Pelvic and bladder pain''' - Pain can develop suddenly and severely, particularly as the bladder fills with urine.
*'''Hematuria''' - Hematuria is visible blood in the urine.
*'''Incontinence''' - This is the leakage of urine.
All of these, however, can be avoided by refraining from using 3-HO-PCE on a daily or even weekly basis and manually limiting one's usage of the substance.
===Dangerous interactions===
{{DangerousInteractions}}
==Legality==
{{legalStub}}
*'''United Kingdom''' - 3-HO-PCE is a class B drug in the UK and is illegal to possess, produce, supply, or import. As a derivative of 1-Phenylcyclohexylamine where the amine has been replaced with a 1-piperidyl group, further substituted in the phenyl ring with a hydroxy substituent, it is covered by the arylcyclohexylamine generic clause added to the Misuse of Drugs Act by S.I. 2013/239, which came into effect on the 26th February 2013.<ref>The Misuse of Drugs Act 1971 (Amendment) Order 2013 (Legislation.gov.uk) | http://www.legislation.gov.uk/uksi/2013/239/introduction/made</ref>
*[https://web.archive.org/web/20170111011440*/https://www.vice.com/en_us/article/interview-with-ketamine-chemist-704-v18n2 Interview with a Ketamine Chemist (VICE)]
==Literature==
* Morris, H., & Wallach, J. (2014). '''''From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs.''''' ''Drug Testing and Analysis'', 6(7–8), 614–632. https://doi.org/10.1002/dta.1620
==References==
<references />
[[Category:Psychoactive substance]]
[[Category:Research chemical]]
[[Category:Arylcyclohexylamine]]
[[Category:Piperidine]]
[[Category:Dissociative]]
{{#set:Featured=true}}
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Unlike its close structural analog 3-HO-PCP, this compound is entirely novel and has no precedent in the scientific literature before being offered on the research chemicals market in the 2010s. Early discussions of this compound have revolved around whether it possesses an appreciable affinity for the mu opioid receptor given its structural relationship to 3-HO-PCP, which is known to possess affinity for the mu opioid receptor.[1]
Following other substances of its class, particularly methoxetamine (MXE), phencyclidine (PCP), and 3-MeO-PCE, it is speculated to to be able to induce a state known as "dissociative anesthesia". However, the extent to which this is currently unclear.[citation needed] Early reports suggest that this state is difficult to reach relative to other dissociatives, and its general effects profile been characterized as "lying halfway between 3-MeO-PCP and 3-MeO-PCE."
Whether it possesses any of its theorized opioid activity in humans is the subject of ongoing debated. There are also reports that suggest this compound may produce more physical side effects such as muscle soreness and flu-like symptoms during or shortly after administration. This suggests it may be uniquely more dangerous or toxic than related dissociatives, particularly at higher doses.
There is a complete lack of data on the pharmacological properties, metabolism, and toxicity of 3-HO-PCE, and it has an extremely brief history of human usage. Today, it is exclusively distributed as a gray area research chemical by online vendors.[2] Due to its potent dissociative and opioid effects, theorized habit-forming properties, and unknown toxicity profile, it is strongly recommended that one use proper harm reduction practices if choosing to use this substance.
As a result, it may contain incomplete or wrong information. You can help by expanding it.
On October 18, 2012 the Advisory Council on the Misuse of Drugs in the United Kingdom released a report about methoxetamine, saying that the "harms of methoxetamine are commensurate with Class B of the Misuse of Drugs Act (1971)", despite the fact that the act does not classify drugs based on harm. The report went on to suggest that all analogues of MXE should also become class B drugs and suggested a catch-all clause covering both existing and unresearched arylcyclohexamines, including 3-HO-PCE.[3]
Chemistry
3-HO-PCE, or 3-hydroxyphencyclidine, is a synthetic dissociative of the arylcyclohexylamine class. 3-HO-PCE contains cyclohexane, a six-member saturated ring, bonded to two additional rings at R1. One of these rings is a piperidine ring, a nitrogenous six member ring, bonded at its nitrogen group. The other ring is an aromatic phenyl ring, substituted at R3 with a hydroxy group.
3-HO-PCE is a PCP analog and structurally homologous to 3-MeO-PCP.
3-HO-PCE acts as an NMDA receptor antagonist. A specific subtype of glutamate receptor, NMDA (N-Methyl-D-Aspartate), modulates the transmission of electrical signals between neurons in the brain and spinal cord; for the signals to pass, the receptor must be open. Dissociatives inhibit the normal functioning NMDA receptors by binding to and blocking them. This disruption of neural network activity leads to loss of normal cognitive and affective processing, psychomotor functioning, anesthesia.[citation needed]
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Spontaneous physical sensations - The body high of this compound can be described in terms of its style variations as a motionless, constant, sharp, all-encompassing, and euphoric activation of nerve endings across the body.
Physical euphoria - 3-HO-PCE has been reported to more readily induce euphoria than most other dissociatives, such as ketamine or diphenidine, especially of the manic variant.
Tactile enhancement and Tactile suppression - At lower dosages, this compound tends to induce tactile enhancements. At higher dosages, this enhancement shifts towards tactile suppressions and anesthesia.
Pain relief - This substance produces distinct nerve-signal blocking anesthetic effects typically required in surgical settings, but only in the stronger to heavier dose ranges.
Bodily control enhancement and Motor control loss - At lower dosages this compound typically induces enhancements in bodily control. At higher dosages, this enhancement shifts towards motor control
Seizure - This extent to which this effect can be produced is unknown but can likely happen in those predisposed to them, especially while in physically taxing conditions such as being dehydrated, fatigued or undernourished.
Compulsive redosing - This effect is more prominent based on the route of administration used. For example, it is especially present when smoked or vaporized, due to the relative abruptness of the substance entering and leaving the bloodstream.
Mania - This effect is reportedly more common on 3-HO-PCE than most other dissociatives. It typically occurs during the offset of the trip, but can also occur during the onset and come up as well.
Psychosis - This effect has been reported to be more common on 3-HO-PCE than most other dissociatives, such as MXE or Ketamine. It typically occurs during the offset of the trip, but can also occur during the onset and come up as well.
Delusions - Like psychosis, this effect is reportedly more common on 3-HO-PCE than most other dissociatives.
Visual acuity enhancement - This effect has been reported as being especially present at low dosages.
Visual acuity suppression - While lower doses of this compound tend to produce mild visual acuity enhancements, this effect quickly disappears as one's general visual faculties become suppressed as the dose is increase.
The toxicity and long-term health effects of recreational 3-HO-PCE use has not been studied in any scientific context and the exact toxic dosage is unknown. This is because 3-HO-PCE has a very short history of human usage.
Tolerance and addiction potential
The chronic use of 3-HO-PCE can be considered highly addictive with a high potential for adverse side effects such as psychosis. In comparison to other dissociatives, 3-HO-PCE has been reported to be more addictive than MXE, diphenidine, ephenidine, DCK, and ketamine. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. There have been multiple reports across the internet of people becoming seriously addicted daily users of this substance so serious precautions and considerations should be taken before trying this substance.
Tolerance to many of the effects of 3-HO-PCE develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 4 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). 3-HO-PCE presents cross-tolerance with [[Cross-tolerance::all dissociatives]], meaning that after the consumption of 3-HO-PCE, all dissociatives will have a reduced effect.
It is strongly recommended that one exercise extreme caution and harm reduction practices when using this substance.
Users should avoid taking the drug multiple days in a row or becoming dependent/addicted to it as this seems to be the main common factor in the observed incidences of severe adverse effects.
The recommended dosage range should not be exceeded as high doses can trigger these effects as well.
Users should start with extremely low doses and work their way up as slowly as possible. Volumetric liquid dosing should preferably be used due to the drug's potency; most standard milligram scales cannot accurately weigh out doses below 10-15mg.[4]
Compulsive redosing before one has fully sobered up is not recommended and can result in too high of a dose.
Due to the risk of psychosis, it is not recommended to combine this drug with other substances, especially stimulants, psychedelics, or other dissociatives like MXE. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
It is strongly recommended that one use harm reduction practices, such as volumetric dosing, when using this substance to ensure the administration of the intended dose.
Urinary tract effects
In terms of its long-term health effects when used repeatedly and excessively for extended periods of time, 3-HO-PCE is likely to exhibit similar bladder and urinary tract problems to those found within ketamine, but to a lesser extent. This is possibly because 3-HO-PCE is far more potent than ketamine so significantly less of drug needs to be consumed. Symptoms of ketamine-induced cystitis can become extremely serious and can be described as:
Urinary frequency - Urinary frequency is the need to empty the bladder every few minutes.
Urinary urgency - This can be described as a sudden, compelling need to urinate.
Urinary pressure - This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination.
Pelvic and bladder pain - Pain can develop suddenly and severely, particularly as the bladder fills with urine.
Hematuria - Hematuria is visible blood in the urine.
Incontinence - This is the leakage of urine.
All of these, however, can be avoided by refraining from using 3-HO-PCE on a daily or even weekly basis and manually limiting one's usage of the substance.
As such, it may contain incomplete or wrong information. You can help by expanding it.
United Kingdom - 3-HO-PCE is a class B drug in the UK and is illegal to possess, produce, supply, or import. As a derivative of 1-Phenylcyclohexylamine where the amine has been replaced with a 1-piperidyl group, further substituted in the phenyl ring with a hydroxy substituent, it is covered by the arylcyclohexylamine generic clause added to the Misuse of Drugs Act by S.I. 2013/239, which came into effect on the 26th February 2013.[5]
Morris, H., & Wallach, J. (2014). From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs.Drug Testing and Analysis, 6(7–8), 614–632. https://doi.org/10.1002/dta.1620
References
↑Kalir, A., S. Maayani, M. Rehavi, R. Elkavetz, I. Pri-Bar, O. Buchman and M. Sokolovsky, 1978, Structure activity relationship of some phencyclidine derivatives; in vivo studies in mice, European J. Med. Chem. 13, 17.
↑Morris, H., & Wallach, J. (2014). From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs. Drug Testing and Analysis, 6(7–8), 614–632. https://doi.org/10.1002/dta.1620
↑ "(ACMD) Methoxetamine Report (2012)" (PDF). UK Home Office. 2012-10-18. p. 14. Retrieved 2015-06-24.
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