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''' | An '''antidepressant''' is a type of psychiatric drug used for treating major depressive disorder (unipolar depression). It is worth noting that many of these agents are not effective for bipolar disorder-associated depression and that antipsychotics such as lurasidone (Latuda) and quetiapine (Seroquel) are used for this purpose. | ||
==Types== | ==Types of antidepressants== | ||
===Selective serotonin reuptake inhibitors=== | ===Selective serotonin reuptake inhibitors (SSRIs)=== | ||
===Serotonin-norepinephrine reuptake | :Selective serotonin reuptake inhibitors are believed to increase the level of extracellular [[serotonin]], therefore allowing more serotonin to be in the brain. The reason SSRIs are used for depression is because | ||
===Serotonin modulators and stimulators=== | ===Serotonin-norepinephrine reuptake inhibitor (SNRIs)=== | ||
===Serotonin antagonists and reuptake inhibitors=== | ===Serotonin modulators and stimulators (SMSes)=== | ||
===Norepinephrine reuptake inhibitors=== | ===Serotonin antagonists and reuptake inhibitors (SARIs)=== | ||
===Tricyclic antidepressants=== | ===Norepinephrine reuptake inhibitors (NRIs)=== | ||
===Tetracyclic antidepressants=== | :NRIs are believed to increase the level of extracellular [[norepinephrine]], therefore allowing more of it to be in the brain. Controversy has been sparked over the effectiveness of reboxetine, an NRI sold as Trintellix. <ref>"Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis." Multiple authors (2009) https://www.researchgate.net/profile/Andrea_Cipriani/publication/23967068_Comparative_efficacy_and_acceptability_of_12_new-generation_antidepressants_A_multiple-treatments_meta-analysis/links/00b7d5278b5bed4c17000000.pdf</ref> | ||
===Monoamine Oxidase Inhibitors=== | ===Norepinephrine-dopamine reuptake inhibitors (NDRIs)=== | ||
:NDRIs are believed to increase the level of extracellular [[norepinephrine]] and [[dopamine]], therefore allowing more of these to be in the brain. Agents such as bupropion (Wellbutrin) have been found effective for MDD with little direct effect on serotonin, and therefore it can be hypothesized that other agents are effective for it. Bupropion and other NDRIs are also effective for depression with fatigue or sleepiness. | |||
===Tricyclic antidepressants (TCAs)=== | |||
===Tetracyclic antidepressants (TeCAs)=== | |||
===Monoamine Oxidase Inhibitors (MAOIs)=== | |||
==Psychedelics for treating depression== | ==Psychedelics for treating depression== | ||
=== | ===Psilocybin mushrooms ("magic mushrooms")=== | ||
===Ketamine=== | ===Ketamine=== | ||
==References== | |||
[[Category:Articles in talk page]] | [[Category:Articles in talk page]] | ||
Revision as of 22:11, 14 September 2017
An antidepressant is a type of psychiatric drug used for treating major depressive disorder (unipolar depression). It is worth noting that many of these agents are not effective for bipolar disorder-associated depression and that antipsychotics such as lurasidone (Latuda) and quetiapine (Seroquel) are used for this purpose.
Types of antidepressants
Selective serotonin reuptake inhibitors (SSRIs)
- Selective serotonin reuptake inhibitors are believed to increase the level of extracellular serotonin, therefore allowing more serotonin to be in the brain. The reason SSRIs are used for depression is because
Serotonin-norepinephrine reuptake inhibitor (SNRIs)
Serotonin modulators and stimulators (SMSes)
Serotonin antagonists and reuptake inhibitors (SARIs)
Norepinephrine reuptake inhibitors (NRIs)
- NRIs are believed to increase the level of extracellular norepinephrine, therefore allowing more of it to be in the brain. Controversy has been sparked over the effectiveness of reboxetine, an NRI sold as Trintellix. [1]
Norepinephrine-dopamine reuptake inhibitors (NDRIs)
- NDRIs are believed to increase the level of extracellular norepinephrine and dopamine, therefore allowing more of these to be in the brain. Agents such as bupropion (Wellbutrin) have been found effective for MDD with little direct effect on serotonin, and therefore it can be hypothesized that other agents are effective for it. Bupropion and other NDRIs are also effective for depression with fatigue or sleepiness.
Tricyclic antidepressants (TCAs)
Tetracyclic antidepressants (TeCAs)
Monoamine Oxidase Inhibitors (MAOIs)
Psychedelics for treating depression
Psilocybin mushrooms ("magic mushrooms")
Ketamine
References
- ↑ "Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis." Multiple authors (2009) https://www.researchgate.net/profile/Andrea_Cipriani/publication/23967068_Comparative_efficacy_and_acceptability_of_12_new-generation_antidepressants_A_multiple-treatments_meta-analysis/links/00b7d5278b5bed4c17000000.pdf