3-HO-PCE

3-MeO-PCE may have a higher risk of causing mania, delusions, and psychosis than other dissociatives.

It is strongly discouraged to take this substance in high dosages, for multiple days in a row, or in combination with other substances known to increase the risk of psychosis. Please see this section for more details.

3-HO-PCE
Chemical Nomenclature
Common names	3-HO-PCE, Hydroxyeticyclidine
Substitutive name	3-Hydroxyeticyclidine
Systematic name	3-[1-(Ethylamino)cyclohexyl]phenol
Class Membership
Psychoactive class	Dissociative
Chemical class	Arylcyclohexylamine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold 5 mg Light 5 - 10 mg Common 10 - 15 mg Strong 15 - 25 mg Heavy 25 mg + Redosing may result in dangerous cumulative effects. Duration Total 4 - 6 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions
Stimulants
Depressants

Summary sheet: 3-HO-PCE

3-HO-PCE is a new dissociative NMDA receptor antagonist and anesthetic drug of the arylcyclohexylamine chemical class. It is extremely potent with a dosage range of 0.5-2mg and is also structurally related to methoxetamine.

This compound induces a state referred to as "dissociative anesthesia" when ingested and is therefore used as a recreational drug. 3-HO-PCE has recently become easily accessible through online research chemical vendors where it is being sold as a designer drug replacement for MXE and other designer dissociatives.

Early reports indicate that 3-HO-PCE shares extremely similar properties to that of 3-MeO-PCP and to a lesser extent, PCP/PCE, MXE and O-PCE, but with what seems to be a moderately higher risk of inducing states of delusions, mania and psychosis. Because of this, it is highly recommended to use responsible drug use practices when using this substance such as using a milligram scale (and preferably volumetric liquid dosing) as well as having a sober trip sitter present throughout the experience.

Chemistry

Generic structure of arylcyclohexylamine molecule

This chemistry section is incomplete. You can help by adding to it.

Pharmacology

Main article: NMDA receptor antagonist

Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other arylcyclohexylamine dissociatives such as DCK and ketamine. With this in mind, 3-HO-PCE is thought to act as an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually this substance's equivalent of the “K-hole.”

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

• Stimulation
• Dizziness
• Increased heart rate
• Motor control loss
• Nausea
• Perception of decreased weight
• Physical autonomy
• Physical euphoria
• Spontaneous tactile sensations
• Tactile disconnection
• Tactile suppression
• Orgasm suppression

Cognitive effects

• Amnesia
• Anxiety suppression
• Consciousness disconnection
• Compulsive redosing
• Conceptual thinking
• Creativity enhancement
• Déjà vu
• Depersonalization
• Derealization
• Disinhibition
• Dream potentiation
• Existential self-realization
• Euphoria
• Memory suppression
  • Ego death
• Immersion enhancement
• Increased music appreciation
• Information processing suppression
• Introspection
• Mania
• Time distortion
• Thought deceleration

Visual effects

Suppression

• Visual disconnection - This eventually results in 3-HO-PCE's equivalent of the famous "k-hole" or, more specifically, holes, spaces and voids alongside of structures.
• Visual acuity suppression
• Double vision
• Pattern recognition suppression
• Frame rate suppression

Distortions

• Perspective distortions
• Environmental cubism
• Environmental orbism
• Scenery slicing

Hallucinatory states

• Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots)

Auditory effects

• Suppression
• Distortions
• Hallucinations

Toxicity and harm potential

Main article: Research chemicals § Toxicity and harm potential

The toxicity and long-term health effects of recreational 3-HO-PCE use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 3-HO-PCE has very little history of human usage. Anecdotal evidence from people who have tried 3-HO-PCE within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).

It is strongly recommended that one use harm reduction practices when using this drug.

Psychosis

3-HO-PCE has been reported to cause psychosis, delusions, and mania at a significantly higher rate than other dissociatives such as ketamine, diphenidine, or MXE. There are a large number of experience reports online which describe states of "psychotic delirium, amnesia, mania, and other serious consequences" after abusing the drug.

It is strongly recommended that one use extreme caution and harm reduction practices when using this substance.

• Users should avoid using the substance multiple days in a row or becoming addicted to it as this increases the risk of severe adverse effects.
• The recommended dosage range should not be exceeded as high doses can trigger these effects as well.
• Users should start with extremely low doses and work their way up as slowly as possible. Volumetric liquid dosing should preferably be used due to the drug's potency; most standard milligram scales cannot accurately weigh out doses below 10-15mg.
• Compulsive redosing before one has fully sobered up is not recommended and can result in too high of a dose.

Due to the risk of psychosis, it is not recommended to combine this drug with other substances, especially stimulants, psychedelics, or other dissociatives like MXE. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

As with other NMDA receptor antagonists, the chronic use of 3-HO-PCE can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Tolerance to many of the effects of 3-HO-PCE develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). 3-HO-PCE presents cross-tolerance with [[Cross-tolerance::all dissociatives]], meaning that after the consumption of 3-HO-PCE all dissociatives will have a reduced effect.

Urinary tract effects

In terms of its long-term health effects when used repeatedly and with excess for extended periods of time, 3-HO-PCE seems to exhibit almost identical bladder and urinary tract problems to those found within ketamine but to a lesser extent. This is because 3-HO-PCE is a little more potent than ketamine, meaning that less of the drug needs to be consumed. Symptoms of ketamine-induced cystitis can become extremely serious and can be described as:

• Urinary frequency - Urinary frequency is the need to empty the bladder every few minutes.
• Urinary urgency - This can be described as a sudden, compelling need to urinate.
• Urinary pressure - This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination.
• Pelvic and bladder pain - Pain can develop suddenly and severely, particularly as the bladder fills with urine.
• Hematuria - Hematuria is visible blood in the urine.
• Incontinence - This is the leakage of urine.

All of these, however, can easily be avoided by simply not using 3-HO-PCE on a daily or even weekly basis and manually limiting one's usage of the substance.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

• Stimulants - Both stimulants and dissociatives carry the risk of adverse psychological reactions like anxiety, mania, delusions and psychosis and these risks are exacerbated when the two substances are combined.
• Depressants - Because both depress the respiratory system, this combination can result in an increased risk of suddenly falling unconscious, vomiting and choking to death from the resulting suffocation. If nausea or vomiting occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.

Legal issues

This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it.

• United Kingdom - 3-HO-PCE is a class B drug in the UK and is illegal to possess, produce, supply, or import. It is likely covered by the arylcyclohexylamine generic clause added to the Misuse of Drugs Act by S.I. 2013/239, which came into effect on the 26th February 2013.

See also

• Responsible use
• Research chemical
• Dissociative
• Methoxetamine
• 3-MeO-PCE
• O-PCM

External links

• 2-Oxo-PCE (Bluelight)
• 3-HO-PCE (TripSit)

Literature

• Morris, H., & Wallach, J. (2014). From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs. Drug Testing and Analysis, 6(7–8), 614–632. https://doi.org/10.1002/dta.1620