Salvinorin B methoxymethyl ether: Difference between revisions
>Dextromethorphan m Natzki moved page Salvinorin B to Salvinorin B methoxymethyl ether: Salvinorin B refers to a wide array of different chemicals |
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| ''[[Salvinorin B methoxymethyl ether/Summary|Summary sheet: Salvinorin B methoxymethyl ether]]'' | |||
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'''Salvinorin B methoxymethyl ether''' (2-O-methoxymethylsalvinorin B) is a semi-synthetic analogue of the natural product [[Salvinorin A]] which is used in scientific research. It has a longer duration of action of around 2–3 hours, compared to less than 30 minutes for salvinorin A, and has increased affinity and potency at the κ-opioid receptor. Like the related compound herkinorin, salvinorin B methoxymethyl ether is made from salvinorin B, which is most conveniently made from salvinorin A by deacetylation, as while both salvinorin A and salvinorin B are found in the plant Salvia divinorum, salvinorin A is present in larger quantities. | '''Salvinorin B methoxymethyl ether''' (2-O-methoxymethylsalvinorin B) is a semi-synthetic analogue of the natural product [[Salvinorin A]] which is used in scientific research. It has a longer duration of action of around 2–3 hours, compared to less than 30 minutes for salvinorin A, and has increased affinity and potency at the κ-opioid receptor. Like the related compound herkinorin, salvinorin B methoxymethyl ether is made from salvinorin B, which is most conveniently made from salvinorin A by deacetylation, as while both salvinorin A and salvinorin B are found in the plant Salvia divinorum, salvinorin A is present in larger quantities. | ||
Revision as of 01:51, 22 November 2016
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Template:SubstanceBox/Salvinorin B
| Summary sheet: Salvinorin B methoxymethyl ether |
Salvinorin B methoxymethyl ether (2-O-methoxymethylsalvinorin B) is a semi-synthetic analogue of the natural product Salvinorin A which is used in scientific research. It has a longer duration of action of around 2–3 hours, compared to less than 30 minutes for salvinorin A, and has increased affinity and potency at the κ-opioid receptor. Like the related compound herkinorin, salvinorin B methoxymethyl ether is made from salvinorin B, which is most conveniently made from salvinorin A by deacetylation, as while both salvinorin A and salvinorin B are found in the plant Salvia divinorum, salvinorin A is present in larger quantities.
Salvinorin B methoxymethyl ether has a Ki of 0.60 nM at the κ opioid receptor, and is around five times more potent than salvinorin A in animal studies, although it is still only half as potent as its stronger homolog salvinorin B ethoxymethyl ether.