Abnormal heartbeat: Difference between revisions
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An '''abnormal heartbeat''' is any of a group of conditions in which the electrical activity of the heart is irregular. The heartbeat may be too fast (over 100 beats per minute) or too slow (less than 60 beats per minute) and may be regular or irregular. A heartbeat that is too fast is called tachycardia and a heartbeat that is too slow is called bradycardia. Although many arrhythmias are not life-threatening, some can cause cardiac arrest. | An '''abnormal heartbeat''' (also called an '''arrhythmia''' or '''dysrhythmia''') is any of a group of conditions in which the electrical activity of the heart is irregular. The heartbeat may be too fast (over 100 beats per minute) or too slow (less than 60 beats per minute) and may be regular or irregular. A heartbeat that is too fast is called tachycardia and a heartbeat that is too slow is called bradycardia. Although many arrhythmias are not life-threatening, some can cause cardiac arrest. | ||
Much like class 1b antiarrhythmics, [[cocaine]] is well known to be a voltage gated sodium ion channel blocker, which may cause potentially fatal arrhythmias such as ventricular tachycardias and QT interval elongation at higher doses.<ref>O’Leary, Michael E, and Jules C Hancox. “Role of Voltage-Gated Sodium, Potassium and Calcium Channels in the Development of Cocaine-Associated Cardiac Arrhythmias.” British Journal of Clinical Pharmacology 69.5 (2010): 427–442. PMC. Web. 27 June 2017.</ref> Parasympatholytics such as [[atropine]] block the vagal effects of [[acetylcholine]] on the sinoatrial node, often resulting in sinus [[tachycardia]], hence atropine is often used clinically for symptomatic [[Decreased heart rate|bradycardia]]. | |||
In the context of substance usage, many compounds alter one's heartrate. For example, [[stimulant]]s tend to increase one's heart rate whilst [[depressants]] tend to decrease it. Combining the two can often result in dangerously irregular heartbeats. | In the context of substance usage, many compounds alter one's heartrate. For example, [[stimulant]]s tend to increase one's heart rate whilst [[depressants]] tend to decrease it. Combining the two can often result in dangerously irregular heartbeats. | ||
Revision as of 18:56, 27 June 2017
An abnormal heartbeat (also called an arrhythmia or dysrhythmia) is any of a group of conditions in which the electrical activity of the heart is irregular. The heartbeat may be too fast (over 100 beats per minute) or too slow (less than 60 beats per minute) and may be regular or irregular. A heartbeat that is too fast is called tachycardia and a heartbeat that is too slow is called bradycardia. Although many arrhythmias are not life-threatening, some can cause cardiac arrest.
Much like class 1b antiarrhythmics, cocaine is well known to be a voltage gated sodium ion channel blocker, which may cause potentially fatal arrhythmias such as ventricular tachycardias and QT interval elongation at higher doses.[1] Parasympatholytics such as atropine block the vagal effects of acetylcholine on the sinoatrial node, often resulting in sinus tachycardia, hence atropine is often used clinically for symptomatic bradycardia.
In the context of substance usage, many compounds alter one's heartrate. For example, stimulants tend to increase one's heart rate whilst depressants tend to decrease it. Combining the two can often result in dangerously irregular heartbeats.
Psychoactive substances
Compounds within our psychoactive substance index which may cause this effect include:
- 2-FA
- 2-FEA
- 2-FMA
- 25B-NBOH
- 25C-NBOH
- 25C-NBOMe
- 25D-NBOMe
- 25I-NBOH
- 25I-NBOMe
- 25N-NBOMe
- 2C-T-21
- 2C-T-7
- 3,4-CTMP
- 3-Cl-PCP
- 3-FEA
- 3-FPM
- 3-HO-PCP
- 3-MMC
- 3-MeO-PCP
- 4-AcO-DET
- 4-FA
- 4-FMA
- 4F-MPH
- 5-APB
- 5-Hydroxytryptophan
- 5-MeO-DiPT
- 5-MeO-MiPT
- 6-APB
- A-PHP
- A-PVP
- Amphetamine
- Benzydamine
- Clonidine
- Cyclazodone
- DOB
- DPT
- Datura
- Dichloropane
- Diphenhydramine
- Ephylone
- Fenethylline
- Harmala alkaloid
- Ibogaine
- Lisdexamfetamine
- MCPP
- MDMA
- MDPV
- MXiPr
- Methadone
- Methylphenidate
Experience reports
Anecdotal reports which describe this effect within our experience index include:
- Experience: 550mg DPH - My First Time on DPH
- Experience:800-900mg Ephenidine + unknown quantity flubroalzolam - Multiday Insanity
- Experience:Clonazolam + 2-methyl-AP-237 (unknown dosage) - Cardiac arrest
- Experience:Unknown dosage / 3 tabs - Ego death and a total break through in the snow
See also
- Responsible use
- Subjective effects index
- Psychedelics - Subjective effects
- Dissociatives - Subjective effects
- Deliriants - Subjective effects
- ↑ O’Leary, Michael E, and Jules C Hancox. “Role of Voltage-Gated Sodium, Potassium and Calcium Channels in the Development of Cocaine-Associated Cardiac Arrhythmias.” British Journal of Clinical Pharmacology 69.5 (2010): 427–442. PMC. Web. 27 June 2017.