This is an unofficial archive of PsychonautWiki as of 2025-08-11T15:14:44Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
Talk:Dextrorphan: Difference between revisions
Jump to navigation
Jump to search
>Oskykins m Text replace - "See Also" to "See also" |
>Halibut Acid mNo edit summary |
||
| Line 1: | Line 1: | ||
{{Stub}} | {{Stub}} | ||
Dextrorphan (DXO) is | Dextrorphan (DXO) is an active metabolite of [[Dextromethorphan]]. This means that DXM is metabolized in the body by o-demethylation through the CYP2D6 enzyme to form DXO, both of which are active chemicals which contribute to the subjective effects experienced when active doses of DXM are consumed. The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an [[NMDA receptor antagonist]] as well as essentially inactive as a [[serotonin]] [[reuptake inhibitor]].<ref>Psychotropic Effects of Dextromethorphan Are Altered by the CYP2D6 Polymorphism: A Pilot Study [http://journals.lww.com/psychopharmacology/pages/articleviewer.aspx?year=1998&issue=08000&article=00014&type=abstract]</ref> One Erowid user reported excessive itchiness accompanied by a "peaceful yet emotionless state." <ref> | ||
"Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student." Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student. Erowid.org, 15 Sept. 2001. Web. 15 Apr. 2015 [https://www.erowid.org/chemicals/dxm/dxm_info3.shtml]</ref> | |||
==See also== | ==See also== | ||
Revision as of 17:40, 15 April 2015
 |
This article is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it. |
Dextrorphan (DXO) is an active metabolite of Dextromethorphan. This means that DXM is metabolized in the body by o-demethylation through the CYP2D6 enzyme to form DXO, both of which are active chemicals which contribute to the subjective effects experienced when active doses of DXM are consumed. The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an NMDA receptor antagonist as well as essentially inactive as a serotonin reuptake inhibitor.[1] One Erowid user reported excessive itchiness accompanied by a "peaceful yet emotionless state." [2]