Talk:Piperine: Difference between revisions
>Catharsis Created page with "{{stub}} {{proofread}} Piperine, along with its isomer chavicine, is the alkaloid responsible for the pungency of black pepper and long pepper. Piperine is commercially availa..." |
>Tracer m Category:Approval |
||
| (17 intermediate revisions by 5 users not shown) | |||
| Line 1: | Line 1: | ||
{ | {| | ||
{{ | |- | ||
| | |||
{{stub}} | |||
|| | |||
In the body, it has been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and metabolites. In animal studies, piperine also inhibited other CYP 450 enzymes important for drug metabolism. | |} | ||
[[File:Piperin.svg|250px|thumbnail|The molecular structure of piperine.]] | |||
'''Piperine''', along with its isomer chavicine, is the alkaloid responsible for the pungency of black pepper and long pepper. Piperine is commercially available as an extract from black pepper using dichloromethane.<ref>Piperine extraction | http://pubs.acs.org/doi/abs/10.1021/ed070p598</ref> Piperine is believed to increase the bioavaliability of a wide range of substances, hypothetically increasing their potency at the cost of duration. | |||
Piperine can be supplemented in the dosage range of 2-5mg for the purpose of potentiating a desired drug's effect. | |||
It should not to be confused with [[piperidine]] | |||
==Pharmacology== | |||
In the body, it has been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and metabolites.<ref>http://jpet.aspetjournals.org/content/302/2/645</ref><ref>https://dx.doi.org/10.1080%2F10408390601062054</ref> In animal studies, piperine also inhibited other CYP 450 enzymes important for drug metabolism.<ref>https://www.ncbi.nlm.nih.gov/pubmed/3917507</ref> | |||
==See also== | |||
*[[Responsible use]] | |||
*[[Modulator]] | |||
*[[Harmala alkaloid]] | |||
*[[Piperidine]] | |||
==External links== | |||
*[[wikipedia:Piperine|Piperine (Wikipedia)]] | |||
==References== | |||
<references /> | |||
[[Category:Approval]] | |||
Latest revision as of 08:45, 28 June 2019
|
Piperine, along with its isomer chavicine, is the alkaloid responsible for the pungency of black pepper and long pepper. Piperine is commercially available as an extract from black pepper using dichloromethane.[1] Piperine is believed to increase the bioavaliability of a wide range of substances, hypothetically increasing their potency at the cost of duration.
Piperine can be supplemented in the dosage range of 2-5mg for the purpose of potentiating a desired drug's effect.
It should not to be confused with piperidine
Pharmacology
In the body, it has been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and metabolites.[2][3] In animal studies, piperine also inhibited other CYP 450 enzymes important for drug metabolism.[4]