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'''N-Methyl-N-propyltryptamine''' (abbreviated '''MPT'''; also known as '''<u>M</u>ethyl<u>p</u>ropyl<u>t</u>ryptamine''') is a synthetic [[psychoactive class::psychedelic]] of the [[tryptamine]] class that has reported to display powerful [[hallucinogen]]ic and sometimes [[entactogen]]ic effects. It is structurally analogous to N,N-dimethyltryptamine ('''[[DMT]]''') and various base psychedelic tryptamines by which one can have a "breahthrough" experience such as [[MET]], [[EPT]], and [[DPT]].
While little is known aboout the pharmacology of this substance, early reports indicate it shares that vaporizing or freebasing the compounds shares most of the core components of the DMT experience, just with its own stylistic pharmacodynamic and kinetic variations.{{citation needed}}
'''N-Methyl-N-propyltryptamine''' (abbreviated '''MPT'''; also known as '''<u>M</u>ethyl<u>p</u>ropyl<u>t</u>ryptamine''') is a synthetic [[psychoactive class::psychedelic]] of the [[tryptamine]] class that has reported to display powerful [[hallucinogen]]ic and sometimes [[entactogen]]ic effects. It is structurally analogous to N,N-dimethyltryptamine ('''[[DMT]]''') and various base psychedelic tryptamines by which one can have a "breakthrough" experience such as [[MET]], [[EPT]], and [[DPT]].
While little is known aboout the pharmacology of this substance, early reports indicate that vaporizing or freebasing the compounds shares most of the core components of the DMT experience, just with its own stylistic pharmacodynamic and kinetic variations.{{citation needed}}
[[MPT]] is extremely uncommon and has little history of human usage. It has never been documented as being sold on the street and is instead primarily acquired through the use of [[research chemical]] vendors and outfits who specialize in the sale of exotic psychoactive chemicals.{{citation needed}}
[[MPT]] is extremely uncommon and has little history of human usage. It has never been documented as being sold on the street and is instead primarily acquired through the use of [[research chemical]] vendors and outfits who specialize in the sale of exotic psychoactive chemicals.{{citation needed}}
==Chemistry==
==Chemistry==
[[File:Tryptamine1.png|thumb|294px|right|Generic structure of a tryptamine molecule]]
[[File:Substituted tryptamine.svg|thumb|294px|right|Generic structure of a tryptamine molecule]]
{{chemistry}}
MPT, or N-methyl-N-propyltryptamine, is a synthetic indole molecule of the [[tryptamine]] class. Tryptamines share a core structure that comprises a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain. Unlike [[DMT]], which contains two methyl groups, MPT contains groups of one methyl and one propyl carbon chains bound to the terminal amine RN of its tryptamine backbone.
n 2019, Chadeayne et al. published the crystal structure of MPT.<ref>{{cite journal | vauthors=((Chadeayne, A. R.)), ((Golen, J. A.)), ((Manke, D. R.)) | journal=IUCrData | title=N -Methyl- N -propyltryptamine (MPT) | volume=4 | issue=7 | pages=x190962 | date=28 July 2019 | url=http://scripts.iucr.org/cgi-bin/paper?S2414314619009623 | issn=2414-3146 | doi=10.1107/S2414314619009623}}</ref> The authors describe the structure as "...a single molecule in the asymmetric unit, with an indole group that demonstrates a mean deviation from planarity of 0.015 A°."
*'''[[Effect::Internal hallucinations]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::alterations in perspective]]'' and ''[[effect::scenarios and plots]]'')
*'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'')
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
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| [[File:Lolol.png|17px]]''Main articles: [[Research chemicals#Toxicity and harm potential|Research chemicals § Toxicity and harm potential]]'' ''&'' ''[[Responsible use #Hallucinogens|Responsible use § Hallucinogens]]''
|}
The toxicity and long-term health effects of recreational MPT use do not appear to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because MPT is a [[research chemical]] with very little history of human use. Anecdotal evidence from people within the psychonaut community who have tried MPT suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
The toxicity and long-term health effects of recreational MPT use do not appear to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because MPT is a [[research chemical]] with very little history of human use. Anecdotal evidence from people within the psychonaut community who have tried MPT suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
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===Dangerous interactions===
===Dangerous interactions===
Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be harmless in low doses of each but still increase the potential risk of death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be harmless in low doses of each but still increase the potential risk of death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
*'''[[Tramadol]]''' - Tramadol lowers seizure threshold<ref>Dose-independent occurrence of seizure with tramadol - Springer | http://link.springer.com/article/10.1007/BF03161089#/page-2</ref> and psychedelics may cause occasional seizures.
*'''[[Tramadol]]''' - Tramadol lowers seizure threshold<ref>{{cite journal|last1=Talaie|first1=H.|last2=Panahandeh|first2=R.|last3=Fayaznouri|first3=M. R.|last4=Asadi|first4=Z.|last5=Abdollahi|first5=M.|title=Dose-independent occurrence of seizure with tramadol|year=2009|journal=Journal of Medical Toxicology|volume=5|issue=2|pages=63-67|doi=10.1007/BF03161089|issn=1556-9039|eissn=1937-6995|oclc=163567183|pmid=19415589|pmc=3550327}}</ref> and psychedelics may cause occasional seizures.
*'''[[Stimulants]]''' - Stimulants may provoke anxiety or thought loops.
*'''[[Stimulants]]''' - Stimulants may provoke anxiety or thought loops.
==Legal issues==
==Legal status==
{{LegalStub}}
{{LegalStub}}
*'''United Kingdom''' - MPT is a class A drug in the UK under a generic clause originally added in 1977 that covers derivatives of tryptamine that are modified by alkyl substitution at the nitrogen atom of the tryptamine side chain.<ref>The Misuse of Drugs Act 1971 (Modification) Order 1977 | http://www.legislation.gov.uk/uksi/1977/1243/made</ref>
*'''Germany''': MPT is controlled under the NpSG (''New Psychoactive Substances Act'')<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz [Federal Ministry of Justice and Consumer Protection]|access-date=December 10, 2019|language=de}}</ref> as of July 18, 2019.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl119s1083.pdf|title=Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes|publisher=Bundesanzeiger Verlag|work=Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27|pages=1083-1094|publication-date=July 17, 2019|access-date=January 1, 2020|language=de}}</ref> Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz [Federal Ministry of Justice and Consumer Protection]|access-date=December 10, 2019|language=de}}</ref>
*'''New Zealand''': MPT is an analogue of [[DMT]], so is a Class C controlled substance in New Zealand.<ref>{{cite web|title=Schedule 1 Class A controlled drugs|url=http://www.legislation.govt.nz/act/public/1975/0116/latest/whole.html#DLM436576|work="Reprint as at 13 August 2019: Misuse of Drugs Act 1975"|access-date=January 7, 2020|publisher=Parliamentary Counsel Office}}</ref>
*'''Switzerland''': MPT is not controlled under Buchstabe A, B, C and D. It could be considered legal.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
*'''United Kingdom''': MPT is a Class A controlled substance in the United Kingdom as a result of the tryptamine catch-all clause.<ref>{{cite web|title=Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=January 7, 2020|publisher=UK Government}}</ref>
*'''United States''': MPT is unscheduled in the United States. It may be considered an analogue of [[DET]], a Schedule I compound under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}}
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
N-Methyl-N-propyltryptamine (abbreviated MPT; also known as Methylpropyltryptamine) is a synthetic psychedelic of the tryptamine class that has reported to display powerful hallucinogenic and sometimes entactogenic effects. It is structurally analogous to N,N-dimethyltryptamine (DMT) and various base psychedelic tryptamines by which one can have a "breakthrough" experience such as MET, EPT, and DPT.
While little is known aboout the pharmacology of this substance, early reports indicate that vaporizing or freebasing the compounds shares most of the core components of the DMT experience, just with its own stylistic pharmacodynamic and kinetic variations.[citation needed]
MPT is extremely uncommon and has little history of human usage. It has never been documented as being sold on the street and is instead primarily acquired through the use of research chemical vendors and outfits who specialize in the sale of exotic psychoactive chemicals.[citation needed]
MPT, or N-methyl-N-propyltryptamine, is a synthetic indole molecule of the tryptamine class. Tryptamines share a core structure that comprises a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain. Unlike DMT, which contains two methyl groups, MPT contains groups of one methyl and one propyl carbon chains bound to the terminal amine RN of its tryptamine backbone.
n 2019, Chadeayne et al. published the crystal structure of MPT.[1] The authors describe the structure as "...a single molecule in the asymmetric unit, with an indole group that demonstrates a mean deviation from planarity of 0.015 A°."
Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other tryptaminepsychedelics such as psilocin and DMT. With this in mind, MPT is thought to act as an 5-HT2Apartial agonist.
However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
There are currently 0 experience reports describing the effects of this substance in our experience index. You can also submit your own experience report using the same link.
The toxicity and long-term health effects of recreational MPT use do not appear to have been studied in any scientific context and the exact toxic dose is unknown. This is because MPT is a research chemical with very little history of human use. Anecdotal evidence from people within the psychonaut community who have tried MPT suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
MPT is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of MPT is built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). MPT presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of MPT all psychedelics will have a reduced effect.
Dangerous interactions
Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be harmless in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
Tramadol - Tramadol lowers seizure threshold[2] and psychedelics may cause occasional seizures.
Stimulants - Stimulants may provoke anxiety or thought loops.
As such, it may contain incomplete or wrong information. You can help by expanding it.
Germany: MPT is controlled under the NpSG (New Psychoactive Substances Act)[3] as of July 18, 2019.[4] Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.[5]
New Zealand: MPT is an analogue of DMT, so is a Class C controlled substance in New Zealand.[6]
Switzerland: MPT is not controlled under Buchstabe A, B, C and D. It could be considered legal.[7]
United Kingdom: MPT is a Class A controlled substance in the United Kingdom as a result of the tryptamine catch-all clause.[8]
United States: MPT is unscheduled in the United States. It may be considered an analogue of DET, a Schedule I compound under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.[citation needed]
↑"Anlage NpSG" (in Deutsch). Bundesministerium der Justiz und für Verbraucherschutz [Federal Ministry of Justice and Consumer Protection]. Retrieved December 10, 2019.
↑"§ 4 NpSG" (in Deutsch). Bundesministerium der Justiz und für Verbraucherschutz [Federal Ministry of Justice and Consumer Protection]. Retrieved December 10, 2019.
↑"Schedule 1 Class A controlled drugs". "Reprint as at 13 August 2019: Misuse of Drugs Act 1975". Parliamentary Counsel Office. Retrieved January 7, 2020.
. PMID 19415589.