Salvinorin B methoxymethyl ether: Difference between revisions
>David Hedlund 2-EMSB, 2-MMSB |
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'''Salvinorin B methoxymethyl ether''' ('''2-O-methoxymethylsalvinorin B | '''Salvinorin B methoxymethyl ether''' ('''2-O-methoxymethylsalvinorin B''', or '''2-MMSB''') is a semi-synthetic analogue of the natural product [[Salvinorin A]] which is used in scientific research. It has a longer duration of action of around 2–3 hours, compared to less than 30 minutes for salvinorin A, and has increased affinity and potency at the κ-opioid receptor. Like the related compound herkinorin, salvinorin B methoxymethyl ether is made from salvinorin B, which is most conveniently made from salvinorin A by deacetylation, as while both salvinorin A and salvinorin B are found in the plant Salvia divinorum, salvinorin A is present in larger quantities. | ||
Salvinorin B methoxymethyl ether has a Ki of 0.60 nM at the κ opioid receptor, and is around five times more potent than salvinorin A in animal studies, although it is still only half as potent as its stronger homolog salvinorin B ethoxymethyl ether. | Salvinorin B methoxymethyl ether has a Ki of 0.60 nM at the κ opioid receptor, and is around five times more potent than salvinorin A in animal studies, although it is still only half as potent as its stronger homolog salvinorin B ethoxymethyl ether. | ||
===Experience reports=== | |||
{{Experience reports|erowid_experience_substance_label=Salvinorin B Ethoxymethyl Ether}} | |||
==See also== | ==See also== | ||
*[[Responsible use]] | *[[Responsible use]] | ||
*[[Salvinorin A]] | *[[Salvinorin A]] | ||
*[[Dissociatives]] | *[[Dissociatives]] | ||
*[[Psychoactive substance index]] | *[[Psychoactive substance index]] | ||
==External links== | |||
*[https://en.wikipedia.org/wiki/Salvinorin_B_methoxymethyl_ether Salvinorin B methoxymethyl ether (Wikipedia)] | |||
*[https://www.erowid.org/chemicals/salvinorin_b_ethoxymethyl_ether/ Salvinorin B methoxymethyl ether (Erowid Vault)] | |||
*[https://isomerdesign.com/PiHKAL/explore.php?id=2842 Salvinorin B methoxymethyl ether (Isomer Design)] | |||
==References== | ==References== | ||
{{references}} | {{references}} | ||
[[Category:Hallucinogen]] | |||
[[Category:Dissociative]] | [[Category:Dissociative]] | ||
[[Category:Psychoactive substance]] | [[Category:Psychoactive substance]] | ||
[[Category:Salvinorin]] | [[Category:Salvinorin]] | ||
[[Category:Terpenoid]] | |||
Latest revision as of 14:22, 2 July 2025
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This article is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it. |
| Summary sheet: Salvinorin B methoxymethyl ether |
| Salvinorin B methoxymethyl ether | |
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| Chemical Nomenclature | |
| Substitutive name | Salvinorin B |
| Systematic name | methyl (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(furan-3-yl)-9-(methoxymethoxy)-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,8,9,10a-octahydro-1H-benzo[f]isochromene-7-carboxylate |
| Class Membership | |
| Psychoactive class | Hallucinogen |
| Chemical class | Salvinorin |
| Interactions | |
Salvinorin B methoxymethyl ether (2-O-methoxymethylsalvinorin B, or 2-MMSB) is a semi-synthetic analogue of the natural product Salvinorin A which is used in scientific research. It has a longer duration of action of around 2–3 hours, compared to less than 30 minutes for salvinorin A, and has increased affinity and potency at the κ-opioid receptor. Like the related compound herkinorin, salvinorin B methoxymethyl ether is made from salvinorin B, which is most conveniently made from salvinorin A by deacetylation, as while both salvinorin A and salvinorin B are found in the plant Salvia divinorum, salvinorin A is present in larger quantities.
Salvinorin B methoxymethyl ether has a Ki of 0.60 nM at the κ opioid receptor, and is around five times more potent than salvinorin A in animal studies, although it is still only half as potent as its stronger homolog salvinorin B ethoxymethyl ether.
Experience reports
There are currently 0 experience reports describing the effects of this substance in our experience index. You can also submit your own experience report using the same link.
Additional experience reports can be found here:
See also
External links
- Salvinorin B methoxymethyl ether (Wikipedia)
- Salvinorin B methoxymethyl ether (Erowid Vault)
- Salvinorin B methoxymethyl ether (Isomer Design)
References
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This article does not cite enough references. You can help by adding some. |