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| {{SummarySheet}}
| | In the bathroom someone threw up, it's probably your girlfriend Power, energy, amphetamine Your homie is fucking semi-conscious girl on the wash machine Power, energy, amphetamine In the kitchen, two tweenies, hand, tit, saliva, saliva Power, energy, amphetamine And someone in the room knelt, with swallowing will be final Power, energy, amphetamine Yesterday melange on tablets, but today is entering amphetamine. |
| {{SubstanceBox/2-FDCK}}
| | Correct eyebrows. Where is the pencil? |
| '''2-Fl-2'-Oxo-PCM''' (also known as '''2-Fluorodeschloroketamine''', '''2-FDCK''', and inaccurately as '''2-Fluroketamine''', '''Fluoroketamine''', and '''2-FK''') is a lesser-known novel [[psychoactive class::dissociative]] substance of the [[Chemical class::arylcyclohexylamine]] class.<ref>{{cite journal | vauthors=((Moghimi, A.)), ((Rahmani, S.)), ((Zare, R.)), ((Sadeghzadeh, M.)) | journal=Synthetic Communications | title=Synthesis of 2-(2-Fluorophenyl)-2-methylamino-Cyclohexanone as a New Ketamine Derivative | volume=44 | issue=14 | pages=2021–2028 | date=18 July 2014 | url=https://doi.org/10.1080/00397911.2014.885053 | issn=0039-7911 | doi=10.1080/00397911.2014.885053}}</ref> It is chemically similar to [[ketamine]] and [[deschloroketamine]] (DCK). It is thought to act as an [[NMDA receptor antagonist]], although research is currently limited.
| | Fuck that, where pencil pouch. It is handbag of amphetamine. |
| | | Rolled new hundred. You to the town in these toe shoes? With Zara still hanging tag. Straight from the Gatty fishnet tights. Wet plate amphetamine sticky. Well, pat in the gums. Each leg toddle, toddle. Chill out, oh the tissue. Think that here is hectare of jive. Lay down on a couch. Do not outflow, it is not a berth. Power, energy, amphetamine Power, energy, amphetamine Power, energy, amphetamine Power, energy, amphetamine Morning gym and a little Metanobol, and in the evening enters amphetamine. |
| The origins of 2F-DCK are not well-documented. It appears to have first become available for sale on the online [[research chemical]] market in 2017, in which it was marketed as a legal replacement for [[ketamine]].<ref name="one">The Big & Dandy 2-Fluoroketamine Thread | http://www.bluelight.org/vb/threads/776753-The-Big-amp-Dandy-2-Fluoroketamine-Thread</ref> It was released after the successful introduction of a similar ketamine analog, [[deschloroketamine]].
| | Nose or bomb is a roulette. Additionally to phase bottle burst. On the windowsill while a meter away. The nose is clogged? Then unplug! Gang in Tico van. Tico is jumping, so it’s orgy. Aeroplane flight over the city. Windows down, chill elbow. Good clothing is a badge, a good shoe is a label. For the party is a cash. For girls chat catch. Each one willing, blonde, brunette. Turbo tongue, cunnilingus master In the bathroom someone threw up, it's probably your girlfriend Power, energy, amphetamine Your homie is fucking semi-conscious girl on the wash machine Power, energy, amphetamine In the kitchen, two tweenies, hand, tit, saliva, saliva Power, energy, amphetamine And someone in the room knelt, with swallowing will be final |
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| [[Subjective effects]] include [[sedation]], [[motor control loss]], [[pain relief]], [[internal hallucinations]], [[conceptual thinking]], [[euphoria]], and [[disconnective effects|dissociation]]. Dissociation is a complex mental state characterized by perceptual distortions and feelings of detachment from the environment and one's self. 2F-DCK's effects are reported to be similar to those of ketamine. Like ketamine, 2F-DCK's effects are highly dose-dependent, with lower doses producing [[alcohol|alcohol-like]] intoxication and higher doses producing [[hallucinogen|hallucinogenic]] out-of-body states (also known as a "k-hole").
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| Limited data exist on the pharmacology, metabolism, or toxicity of 2-FDCK. It has an extremely brief history of human use. It is strongly advised to use [[harm reduction practices]] if using this substance.
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| ==Chemistry==
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| 2-Fluorodeschloroketamine, or 2-(2-Fluorophenyl)-2-methylamino-cyclohexanone, is classed as an [[arylcyclohexylamine]] drug. Arylcyclohexylamines drugs are named for their structures which include a cyclohexane ring bound to an aromatic ring along with an amine group. 2-FDCK contains a phenyl ring bonded to a cyclohexane ring substituted with a ketone group (cyclohexanone). An amino methyl chain (-N-CH<sub>3</sub>) is bound to the adjacent alpha carbon (R<sub>2</sub>) of the cyclohexanone ring. Additionally, the phenyl ring is substituted at R<sub>2</sub> with a fluorine group.
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| 2-Fluorodescholoroketamine is a chiral molecule and is often produced as a racemate. Des- is a prefix used in chemistry to denote the absence of a functional group (in this case "chloro") hence 2-FDCK is named for containing a fluorine substitution at its phenyl ring rather than the chlorine which is found in [[ketamine]].
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| ==Pharmacology==
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| {{Further|NMDA receptor antagonist}}
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| Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other [[arylcyclohexylamine]] [[dissociative|dissociatives]] such as [[DCK]] and [[ketamine]]. With this in mind, 2-Fluorodeschloroketamine is thought to act as an [[NMDA receptor antagonist]].
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| NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually this substance's equivalent of the “[[Visual_disconnection#Holes.2C_spaces_and_voids|K-hole]].”
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| ==Subjective effects==
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| {{effectStub}}
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| {{Preamble/SubjectiveEffects}}
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| {{effects/base
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| |{{effects/physical|
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| *'''[[Effect::Pain relief]]'''
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| *'''[[Effect::Spontaneous physical sensations]]'''
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| *'''[[Effect::Physical euphoria]]'''
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| *'''[[Effect::Dizziness]]'''
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| *'''[[Effect::Motor control loss]]'''
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| *'''[[Effect::Nausea]]'''
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| *'''[[Effect::Perception of bodily lightness]]'''
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| *'''[[Effect::Physical autonomy]]'''
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| *'''[[Effect::Spatial disorientation]]'''
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| *'''[[Effect::Tactile suppression]]'''
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| *'''[[Effect::Orgasm suppression]]'''
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| }}
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| {{effects/disconnective|
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| *'''[[Effect::Tactile disconnection]]'''
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| *'''[[Effect::Visual disconnection]]''' - This eventually results in 2-Fluorodeschloroketamine's equivalent of the "[https://en.wikipedia.org/wiki/K-hole k-hole]" or, more specifically, ''[[Visual disconnection#Holes, spaces and voids|holes, spaces and voids]]'' alongside of ''[[Visual disconnection#Structures|structures]]''.
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| *'''[[Effect::Consciousness disconnection]]'''
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| }}
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| {{effects/visual|
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| ====Suppression====
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| *'''[[Effect::Double vision]]'''
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| *'''[[Effect::Frame rate suppression]]'''
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| *'''[[Effect::Pattern recognition suppression]]'''
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| *'''[[Effect::Visual acuity suppression]]'''
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| ====Distortions====
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| *'''[[Effect::Environmental cubism]]'''
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| *'''[[Effect::Environmental orbism]]'''
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| *'''[[Effect::Perspective distortions]]'''
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| *'''[[Effect::Scenery slicing]]'''
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| ====[[Effect::Geometry]]====
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| ====Hallucinatory states====
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| *'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'')
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| }}
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| |{{effects/cognitive|
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| The cognitive effects of 2-FDCK are best compared to [[ketamine]] and some users find the effects nearly indistinguishable. Subjectively, the experience on 2-FDCK tends to be paced at a slower rate alongside distinct psychedelic effects which differ slightly from ketamine. Some users also report that 2-FDCK can sometimes produce slightly more confusion and generally more difficulty to "hole" with higher dosages, while others don't seem to notice this and instead treat it being equally enjoyable whilst also retaining the same antidepressant effects that ketamine produces.
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| *'''[[Effect::Anxiety suppression]]'''
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| *'''[[Effect::Compulsive redosing]]'''
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| *'''[[Effect::Conceptual thinking]]'''
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| *'''[[Effect::Creativity enhancement]]'''
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| *'''[[Effect::Déjà vu]]'''
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| *'''[[Effect::Depersonalization]]'''
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| *'''[[Effect::Derealization]]'''
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| *'''[[Effect::Disinhibition]]'''
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| *'''[[Effect::Dream potentiation]]'''
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| *'''[[Effect::Cognitive euphoria]]
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| *'''[[Effect::Immersion enhancement]]'''
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| *'''[[Effect::Analysis suppression]]'''
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| *'''[[Effect::Introspection]]'''
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| *'''[[Effect::Memory suppression]]'''
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| **'''[[Effect::Ego death]]'''
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| **'''[[Effect::Amnesia]]'''
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| *'''[[Effect::Time distortion]]'''
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| *'''[[Effect::Thought deceleration]]'''
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| *'''[[Effect::Increased music appreciation]]'''
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| }}
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| {{effects/auditory|
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| *'''[[Effect::Auditory distortion|Distortions]]'''
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| *'''[[Effect::Auditory hallucinations|Hallucinations]]'''
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| *'''[[Effect::Auditory suppression|Suppression]]'''
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| }}
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| }}
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| ===Experience reports===
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| There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]]. Additional experience reports can be found here:
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| *[https://www.erowid.org/experiences/subs/exp_2Fluorodeschloroketamine.shtml Erowid Experience Vaults: 2-Fluorodeschloroketamine]
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| ==Toxicity and harm potential==
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| {{toxicity}}
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| {{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
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| The toxicity and long-term health effects of recreational 2-Fluorodeschloroketamine use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is because 2-Fluorodeschloroketamine has very little history of human usage. Anecdotal evidence from people who have tried 2-Fluorodeschloroketamine within the community suggests that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).
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| It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.
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| ===Dependence and abuse potential===
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| As with other NMDA receptor antagonists, the chronic use of 2-Fluorodeschloroketamine can be considered [[Addiction potential::moderately addictive with a high potential for abuse]] and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage.
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| Tolerance to many of the effects of 2-Fluorodeschloroketamine [[Time to full tolerance::develops with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). 2-Fluorodeschloroketamine presents cross-tolerance with [[Cross-tolerance::all [[dissociative]]s]], meaning that after the consumption of 2-Fluorodeschloroketamine all [[dissociative]]s will have a reduced effect.
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| ===Urinary tract effects===
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| In terms of its long-term health effects when used repeatedly and with excess for extended periods of time, 2-Fluorodeschloroketamine seems to exhibit almost identical bladder and urinary tract problems to those found within [[ketamine]] but to a lesser extent. This is because 2-Fluorodeschloroketamine is a little more potent than ketamine, meaning that less of the drug needs to be consumed. Symptoms of ketamine-induced cystitis can become extremely serious and include:
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| *'''Urinary frequency''' - Urinary frequency is the need to empty the bladder every few minutes.
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| *'''Urinary urgency''' - This can be described as a sudden, compelling need to urinate.
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| *'''Urinary pressure''' - This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination.
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| *'''Pelvic and bladder pain''' - Pain can develop suddenly and severely, particularly as the bladder fills with urine.
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| *'''Hematuria''' - Hematuria is visible blood in the urine.
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| *'''Incontinence''' - This is the leakage of urine.
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| All of these, however, can easily be avoided by simply not using 2-Fluorodeschloroketamine on a daily or even weekly basis and manually limiting one's usage of the substance.
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| ===Dangerous interactions===
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| {{DangerousInteractions/Intro}}
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| *'''[[UncertainInteraction::Benzodiazepines]]''' - Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position.
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| *'''[[UncertainInteraction::MAOIs]]''' - MAO-B inhibitors appear to increase the potency of ketamine. MAO-A inhibitors have some negative reports associated with the combination but there isn't much information available
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| *'''[[DangerousInteraction::Alcohol]]''' - Both substances cause ataxia and bring a very high risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
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| *'''[[DangerousInteraction::GHB]]''' - Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
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| *'''[[DangerousInteraction::GBL]]''' - Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
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| *'''[[DangerousInteraction::Opioids]]''' - Both substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
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| *'''[[DangerousInteraction::Tramadol]]''' - Potential increased risk of seizures.
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| *'''Grapefruit''' - Grapefruit juice significantly increases oral absorption of ketamine. This may result in the user having double the concentration of ketamine in their system compared to normal. The ketamine may also have a longer duration of effect.<ref>{{cite journal | vauthors=((Peltoniemi, M. A.)), ((Saari, T. I.)), ((Hagelberg, N. M.)), ((Laine, K.)), ((Neuvonen, P. J.)), ((Olkkola, K. T.)) | journal=European Journal of Clinical Pharmacology | title=S-ketamine concentrations are greatly increased by grapefruit juice | volume=68 | issue=6 | pages=979–986 | date= June 2012 | issn=1432-1041 | doi=10.1007/s00228-012-1214-9}}</ref> It is likely that this property extends to 2F-DCK as well.
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| ==Legal status==
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| *'''Austria:''' 2-Fluorodeschloroketamine is illegal to possess, produce and sell under the NPSG. (Neue-Psychoaktive-Substanzen-Gesetz Österreich) <ref>{{Citation | title=RIS - Neue-Psychoaktive-Substanzen-Verordnung - Bundesrecht konsolidiert, Fassung vom 21.07.2022 | url=https://www.ris.bka.gv.at/GeltendeFassung.wxe?Abfrage=Bundesnormen&Gesetzesnummer=20007642}}</ref>
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| *'''Canada:''' 2-Fluorodeschloroketamine is not specifically listed in the Controlled Drugs and Substances Act (CDSA) but could be considered controlled under schedule I: "14 Phencyclidine (1-(1-phenylcyclohexyl)piperidine), its salts, derivatives and analogues and salts of derivatives and analogues, including: (1) Ketamine . . ." It could presumably be considered an analogue of PCP due to its structural similarity to ketamine. <ref>Controlled Drugs and Substances Act (S.C. 1996, c. 19) | http://laws-lois.justice.gc.ca/PDF/C-38.8.pdf</ref>
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| *'''Czech Republic:''' 6-APB is a Schedule I (List 4) substance. It may be used for research and restricted therapeutic purposes. (§ 1, d), 1. of ''Nařízení vlády č. 463/2013 Sb.'') <ref>https://www.zakonyprolidi.cz/cs/2013-463?text=o+seznamech+n%C3%A1vykov%C3%BDch</ref>
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| *'''Germany:''' 2-Fluorodeschloroketamine is controlled under the NpSG (''New Psychoactive Substances Act'')<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz [Federal Ministry of Justice and Consumer Protection]|access-date=December 10, 2019|language=de}}</ref> as of July 18, 2019.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl119s1083.pdf|title=Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes|publisher=Bundesanzeiger Verlag|work=Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27|pages=1083-1094|publication-date=July 17, 2019|access-date=January 1, 2020|language=de}}</ref> Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz [Federal Ministry of Justice and Consumer Protection]|access-date=December 10, 2019|language=de}}</ref>
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| *'''Italy:''' 2-Fluorodeschloroketamine is a Schedule I (''Tabella I'') controlled substance.<ref>{{cite web|title=Tabella delle sostanze stupefacenti e psicotrope|url=http://www.salute.gov.it/imgs/C_17_pagineAree_3729_0_file.pdf|access-date=November 24, 2020|language=it|publisher=Ministero della Salute [Ministry of Health]}}</ref>
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| *'''Latvia:''' 2-Fluorodeschloroketamine is illegal in Latvia.<ref>http://www.vm.gov.lv/images/userfiles/metodiskas_vadlinijas_080914.doc</ref>
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| *'''Switzerland:''' 2-Fluorodeschloroketamine is a controlled substance specifically named under Verzeichnis E.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
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| *'''Turkey:''' 2-Fluorodeschloroketamine is a classed as drug and is illegal to possess, produce, supply, or import.<ref>{{cite web|title=Cumhurbaşkanı Kararı: Karar Sayısı: 1335|url=https://resmigazete.gov.tr/eskiler/2019/07/20190720-19.pdf|publisher=Başbakanlık Mevzuatı Geliştirme ve Yayın Genel Müdürlüğü [General Directorate of Legislation Development and Publication]|publication-date=July 20, 2019|date=July 19, 2020|work=Resmî Gazete, Sayı: 30837|language=tr}}</ref>
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| *'''United Kingdom:''' 2-Fluorodeschloroketamine is a class B drug in the UK and is illegal to possess, produce, supply, or import. As an N-alkyl derivative of 2-Amino-2-phenylcyclohexanone substituted in the phenyl ring with a halide substituent, it is covered by the arylcyclohexylamine generic clause added to the Misuse of Drugs Act by S.I. 2013/239, which came into effect on the 26th February 2013.<ref>{{Citation | title=The Misuse of Drugs Act 1971 (Amendment) Order 2013 | url=https://www.legislation.gov.uk/uksi/2013/239/introduction/made}}</ref>
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| ==See also==
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| *[[Responsible use]]
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| *[[Designer drug]]
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| *[[Dissociatives]]
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| *[[Arylcyclohexylamines]]
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| *[[Deschloroketamine]] (''O-PCM'')
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| *[[MXE]]
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| ==External links==
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| *[https://en.wikipedia.org/wiki/2-Fluorodeschloroketamine 2-Fluorodeschloroketamine (Wikipedia)]
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| *[https://isomerdesign.com/PiHKAL/explore.php?id=981 2-Fluorodeschloroketamine (Isomer Design)]
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| *[http://www.bluelight.org/vb/threads/776753-The-Big-amp-Dandy-2-Fluoroketamine-Thread The Big & Dandy 2-Fluoroketamine Thread (Bluelight)]
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| ==References==
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| <references />
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| [[Category:Arylcyclohexylamine]]
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| [[Category:Dissociative]]
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| [[Category:Research chemical]]
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In the bathroom someone threw up, it's probably your girlfriend Power, energy, amphetamine Your homie is fucking semi-conscious girl on the wash machine Power, energy, amphetamine In the kitchen, two tweenies, hand, tit, saliva, saliva Power, energy, amphetamine And someone in the room knelt, with swallowing will be final Power, energy, amphetamine Yesterday melange on tablets, but today is entering amphetamine.
Correct eyebrows. Where is the pencil?
Fuck that, where pencil pouch. It is handbag of amphetamine.
Rolled new hundred. You to the town in these toe shoes? With Zara still hanging tag. Straight from the Gatty fishnet tights. Wet plate amphetamine sticky. Well, pat in the gums. Each leg toddle, toddle. Chill out, oh the tissue. Think that here is hectare of jive. Lay down on a couch. Do not outflow, it is not a berth. Power, energy, amphetamine Power, energy, amphetamine Power, energy, amphetamine Power, energy, amphetamine Morning gym and a little Metanobol, and in the evening enters amphetamine.
Nose or bomb is a roulette. Additionally to phase bottle burst. On the windowsill while a meter away. The nose is clogged? Then unplug! Gang in Tico van. Tico is jumping, so it’s orgy. Aeroplane flight over the city. Windows down, chill elbow. Good clothing is a badge, a good shoe is a label. For the party is a cash. For girls chat catch. Each one willing, blonde, brunette. Turbo tongue, cunnilingus master In the bathroom someone threw up, it's probably your girlfriend Power, energy, amphetamine Your homie is fucking semi-conscious girl on the wash machine Power, energy, amphetamine In the kitchen, two tweenies, hand, tit, saliva, saliva Power, energy, amphetamine And someone in the room knelt, with swallowing will be final
