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| {{SummarySheet}}
| | In the bathroom someone threw up, it's probably your girlfriend Power, energy, amphetamine Your homie is fucking semi-conscious girl on the wash machine Power, energy, amphetamine In the kitchen, two tweenies, hand, tit, saliva, saliva Power, energy, amphetamine And someone in the room knelt, with swallowing will be final Power, energy, amphetamine Yesterday melange on tablets, but today is entering amphetamine. |
| {{SubstanceBox/2-FDK}}
| | Correct eyebrows. Where is the pencil? |
| | | Fuck that, where pencil pouch. It is handbag of amphetamine. |
| '''2-Fl-2'-Oxo-PCM''' (also known as '''2-Fluorodeschloroketamine''', '''2-FDCK''', and inaccurately as '''2-Fluroketamine''', '''Fluoroketamine''', and '''2-FK''') is a lesser-known novel [[psychoactive class::dissociative]] substance of the [[Chemical class::arylcyclohexylamine]] class<ref>Synthesis of 2-(2-Fluorophenyl)-2-methylamino-Cyclohexanone as a New Ketamine Derivative | http://www.tandfonline.com/doi/abs/10.1080/00397911.2014.885053#.VxH5USZVK1E</ref> that produces [[dissociative]], [[pain relief|anesthetic]], and [[hallucinogenic]] effects when [[route of administration|administered]]. It is structurally related to [[arylcyclohexylamines]] like [[ketamine]] and [[deschloroketamine]] and is reported to produce similar effects.
| | Rolled new hundred. You to the town in these toe shoes? With Zara still hanging tag. Straight from the Gatty fishnet tights. Wet plate amphetamine sticky. Well, pat in the gums. Each leg toddle, toddle. Chill out, oh the tissue. Think that here is hectare of jive. Lay down on a couch. Do not outflow, it is not a berth. Power, energy, amphetamine Power, energy, amphetamine Power, energy, amphetamine Power, energy, amphetamine Morning gym and a little Metanobol, and in the evening enters amphetamine. |
| | | Nose or bomb is a roulette. Additionally to phase bottle burst. On the windowsill while a meter away. The nose is clogged? Then unplug! Gang in Tico van. Tico is jumping, so it’s orgy. Aeroplane flight over the city. Windows down, chill elbow. Good clothing is a badge, a good shoe is a label. For the party is a cash. For girls chat catch. Each one willing, blonde, brunette. Turbo tongue, cunnilingus master In the bathroom someone threw up, it's probably your girlfriend Power, energy, amphetamine Your homie is fucking semi-conscious girl on the wash machine Power, energy, amphetamine In the kitchen, two tweenies, hand, tit, saliva, saliva Power, energy, amphetamine And someone in the room knelt, with swallowing will be final |
| Like other dissociative substances, it is primarily sought by recreational users for its ability to induce a [[hallucinogenic]] "out of body" state referred to as "[[dissociatives#Subjective effects|dissociative anesthesia]]" (although the extent to which this occurs is highly dose-dependent). It has recently become available through online [[research chemical]] vendors where it is being sold as a [[designer drug]] replacement for [[ketamine]].<ref name="one">The Big & Dandy 2-Fluoroketamine Thread | http://www.bluelight.org/vb/threads/776753-The-Big-amp-Dandy-2-Fluoroketamine-Thread</ref>
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| There is very little information on the pharmacology, metabolism or toxicity of 2-fluorodeschloroketamine. It has an extremely brief history of human use. It is strongly advised to use [[harm reduction practices]] if using this substance.
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| ==Chemistry==
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| 2-Fluorodeschloroketamine, or 2-(2-Fluorophenyl)-2-methylamino-cyclohexanone, is classed as an [[arylcyclohexylamine]] drug. Arylcyclohexylamines drugs are named for their structures which include a cyclohexane ring bound to an aromatic ring along with an amine group. 2-FDCK contains a phenyl ring bonded to a cyclohexane ring substituted with a ketone group (cyclohexanone). An amino methyl chain (-N-CH<sub>3</sub>) is bound to the adjacent alpha carbon (R<sub>2</sub>) of the cyclohexanone ring. Additionally, the phenyl ring is substituted at R<sub>2</sub> with a fluorine group.
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| 2-Fluorodescholoroketamine is a chiral molecule and is often produced as a racemate. Des- is a prefix used in chemistry to denote the absence of a functional group (in this case "chloro") hence 2-FDCK is named for containing a fluorine substitution at its phenyl ring rather than the chlorine which is found in [[ketamine]].
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| ==Pharmacology==
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| {{Further|NMDA receptor antagonist}}
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| Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other [[arylcyclohexylamine]] [[dissociative|dissociatives]] such as [[DCK]] and [[ketamine]]. With this in mind, 2-Fluorodeschloroketamine is thought to act as an [[NMDA receptor antagonist]].
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| NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually this substance's equivalent of the “[[Visual_disconnection#Holes.2C_spaces_and_voids|K-hole]].”
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| ==Subjective effects==
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| {{effectStub}}
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| {{Preamble/SubjectiveEffects}}
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| {{effects/base
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| |{{effects/physical|
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| *'''[[Effect::Pain relief]]'''
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| *'''[[Effect::Spontaneous physical sensations]]'''
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| *'''[[Effect::Physical euphoria]]'''
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| *'''[[Effect::Dizziness]]'''
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| *'''[[Effect::Motor control loss]]'''
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| *'''[[Effect::Nausea]]'''
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| *'''[[Effect::Perception of bodily lightness]]'''
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| *'''[[Effect::Physical autonomy]]'''
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| *'''[[Effect::Spatial disorientation]]'''
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| *'''[[Effect::Tactile suppression]]'''
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| *'''[[Effect::Orgasm suppression]]'''
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| }}
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| {{effects/disconnective|
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| *'''[[Effect::Tactile disconnection]]'''
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| *'''[[Effect::Visual disconnection]]''' - This eventually results in 2-Fluorodeschloroketamine's equivalent of the "[https://en.wikipedia.org/wiki/K-hole k-hole]" or, more specifically, ''[[Visual disconnection#Holes, spaces and voids|holes, spaces and voids]]'' alongside of ''[[Visual disconnection#Structures|structures]]''.
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| *'''[[Effect::Consciousness disconnection]]'''
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| }}
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| {{effects/visual|
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| ====Suppression====
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| *'''[[Effect::Double vision]]'''
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| *'''[[Effect::Frame rate suppression]]'''
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| *'''[[Effect::Pattern recognition suppression]]'''
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| *'''[[Effect::Visual acuity suppression]]'''
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| ====Distortions====
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| *'''[[Effect::Environmental cubism]]'''
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| *'''[[Effect::Environmental orbism]]'''
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| *'''[[Effect::Perspective distortions]]'''
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| *'''[[Effect::Scenery slicing]]'''
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| ====[[Effect::Geometry]]====
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| ====Hallucinatory states====
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| *'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'')
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| }}
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| |{{effects/cognitive|
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| *'''[[Effect::Anxiety suppression]]'''
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| *'''[[Effect::Compulsive redosing]]'''
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| *'''[[Effect::Conceptual thinking]]'''
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| *'''[[Effect::Creativity enhancement]]'''
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| *'''[[Effect::Déjà vu]]'''
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| *'''[[Effect::Depersonalization]]'''
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| *'''[[Effect::Derealization]]'''
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| *'''[[Effect::Disinhibition]]'''
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| *'''[[Effect::Dream potentiation]]'''
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| *'''[[Effect::Cognitive euphoria]]
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| *'''[[Effect::Immersion enhancement]]'''
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| *'''[[Effect::Analysis suppression]]'''
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| *'''[[Effect::Introspection]]'''
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| *'''[[Effect::Memory suppression]]'''
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| **'''[[Effect::Ego death]]'''
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| **'''[[Effect::Amnesia]]'''
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| *'''[[Effect::Time distortion]]'''
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| *'''[[Effect::Thought deceleration]]'''
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| }}
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| {{effects/auditory|
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| *'''[[Effect::Auditory distortion|Distortions]]'''
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| *'''[[Effect::Auditory hallucinations|Hallucinations]]'''
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| *'''[[Effect::Auditory suppression|Suppression]]'''
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| }}
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| }}
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| ===Experience reports===
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| There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]]. Additional experience reports can be found here:
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| * [https://www.erowid.org/experiences/subs/exp_2Fluorodeschloroketamine.shtml Erowid Experience Vaults: 2-Fluorodeschloroketamine]
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| ==Toxicity and harm potential==
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| {{toxicity}}
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| {{Further|Research chemicals#Toxicity and harm potential}}
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| The toxicity and long-term health effects of recreational 2-Fluorodeschloroketamine use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is because 2-Fluorodeschloroketamine has very little history of human usage. Anecdotal evidence from people who have tried 2-Fluorodeschloroketamine within the community suggests that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).
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| It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.
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| ===Dependence and abuse potential===
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| As with other NMDA receptor antagonists, the chronic use of 2-Fluorodeschloroketamine can be considered [[Addiction potential::moderately addictive with a high potential for abuse]] and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage.
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| Tolerance to many of the effects of 2-Fluorodeschloroketamine [[Time to full tolerance::develops with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). 2-Fluorodeschloroketamine presents cross-tolerance with [[Cross-tolerance::all [[dissociative]]s]], meaning that after the consumption of 2-Fluorodeschloroketamine all [[dissociative]]s will have a reduced effect.
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| ===Urinary tract effects===
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| In terms of its long-term health effects when used repeatedly and with excess for extended periods of time, 2-Fluorodeschloroketamine seems to exhibit almost identical bladder and urinary tract problems to those found within [[ketamine]] but to a lesser extent. This is because 2-Fluorodeschloroketamine is a little more potent than ketamine, meaning that less of the drug needs to be consumed. Symptoms of ketamine-induced cystitis can become extremely serious and can be described as:
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| *'''Urinary frequency''' - Urinary frequency is the need to empty the bladder every few minutes.
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| *'''Urinary urgency''' - This can be described as a sudden, compelling need to urinate.
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| *'''Urinary pressure''' - This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination.
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| *'''Pelvic and bladder pain''' - Pain can develop suddenly and severely, particularly as the bladder fills with urine.
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| *'''Hematuria''' - Hematuria is visible blood in the urine.
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| *'''Incontinence''' - This is the leakage of urine.
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| All of these, however, can easily be avoided by simply not using 2-Fluorodeschloroketamine on a daily or even weekly basis and manually limiting one's usage of the substance.
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| ===Dangerous interactions===
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| {{DangerousInteractions/Intro}}
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| {{DangerousInteractions/Dissos}}
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| ==Legal status==
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| *'''Austria:''' 2-Fluorodeschloroketamine is illegal to possess, produce and sell under the NPSG. (Neue-Psychoaktive-Substanzen-Gesetz Österreich) {{citation needed}}
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| *'''Canada:''' 2-Fluorodeschloroketamine is not specifically listed in the Controlled Drugs and Substances Act (CDSA) but could be considered controlled under schedule I: "14 Phencyclidine (1-(1-phenylcyclohexyl)piperidine), its salts, derivatives and analogues and salts of derivatives and analogues, including: (1) Ketamine . . ." It could presumably be considered an analogue of PCP due to its structural similarity to ketamine. <ref>Controlled Drugs and Substances Act (S.C. 1996, c. 19) | http://laws-lois.justice.gc.ca/PDF/C-38.8.pdf</ref>
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| *'''Germany:''' 2-Fluorodeschloroketamine is not a controlled substance under the BtMG.<ref>http://www.gesetze-im-internet.de/btmg_1981/anlage_i.html</ref> It is legal, as long as it is not sold for human consumption, according to §2 AMG.<ref>https://www.gesetze-im-internet.de/amg_1976/__2.html</ref>
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| *'''Latvia:''' 2-Fluorodeschloroketamine is illegal in Latvia.<ref>http://www.vm.gov.lv/images/userfiles/metodiskas_vadlinijas_080914.doc</ref>
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| *'''United Kingdom:''' 2-Fluorodeschloroketamine is a class B drug in the UK and is illegal to possess, produce, supply, or import. As an N-alkyl derivative of 2-Amino-2-phenylcyclohexanone substituted in the phenyl ring with a halide substituent, it is covered by the arylcyclohexylamine generic clause added to the Misuse of Drugs Act by S.I. 2013/239, which came into effect on the 26th February 2013.<ref>The Misuse of Drugs Act 1971 (Amendment) Order 2013 (Legislation.gov.uk) | http://www.legislation.gov.uk/uksi/2013/239/introduction/made</ref>
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| ==See also==
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| *[[Responsible use]]
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| *[[Designer drug]]
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| *[[Dissociatives]]
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| *[[Arylcyclohexylamines]]
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| *[[Deschloroketamine]] (''O-PCM'')
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| *[[MXE]]
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| ==External links==
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| *[https://en.wikipedia.org/wiki/2-Fluorodeschloroketamine 2-Fluorodeschloroketamine (Wikipedia)]
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| *[https://isomerdesign.com/PiHKAL/explore.php?id=981 2-Fluorodeschloroketamine (Isomer Design)]
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| *[http://www.bluelight.org/vb/threads/776753-The-Big-amp-Dandy-2-Fluoroketamine-Thread The Big & Dandy 2-Fluoroketamine Thread (Bluelight)]
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| ==References==
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| <references />
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| [[Category:Psychoactive substance]]
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| [[Category:Research chemical]]
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| [[Category:Arylcyclohexylamine]]
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| [[Category:Hallucinogen]]
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| [[Category:Dissociative]]
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In the bathroom someone threw up, it's probably your girlfriend Power, energy, amphetamine Your homie is fucking semi-conscious girl on the wash machine Power, energy, amphetamine In the kitchen, two tweenies, hand, tit, saliva, saliva Power, energy, amphetamine And someone in the room knelt, with swallowing will be final Power, energy, amphetamine Yesterday melange on tablets, but today is entering amphetamine.
Correct eyebrows. Where is the pencil?
Fuck that, where pencil pouch. It is handbag of amphetamine.
Rolled new hundred. You to the town in these toe shoes? With Zara still hanging tag. Straight from the Gatty fishnet tights. Wet plate amphetamine sticky. Well, pat in the gums. Each leg toddle, toddle. Chill out, oh the tissue. Think that here is hectare of jive. Lay down on a couch. Do not outflow, it is not a berth. Power, energy, amphetamine Power, energy, amphetamine Power, energy, amphetamine Power, energy, amphetamine Morning gym and a little Metanobol, and in the evening enters amphetamine.
Nose or bomb is a roulette. Additionally to phase bottle burst. On the windowsill while a meter away. The nose is clogged? Then unplug! Gang in Tico van. Tico is jumping, so it’s orgy. Aeroplane flight over the city. Windows down, chill elbow. Good clothing is a badge, a good shoe is a label. For the party is a cash. For girls chat catch. Each one willing, blonde, brunette. Turbo tongue, cunnilingus master In the bathroom someone threw up, it's probably your girlfriend Power, energy, amphetamine Your homie is fucking semi-conscious girl on the wash machine Power, energy, amphetamine In the kitchen, two tweenies, hand, tit, saliva, saliva Power, energy, amphetamine And someone in the room knelt, with swallowing will be final
