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Template:SubstanceBox/Melatonin: Difference between revisions

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>Unity
m Text replacement - "MolecularStructureCaption=The skeletal formula" to "MolecularStructureCaption=Molecular structure"
>Isaak
Time to peak concentration is 60+-30 minutes and half life is 60+-10minutes according to linked study
 
(17 intermediate revisions by 8 users not shown)
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{{SubstanceBox
{{SubstanceBox


     <!-- Table Properties -->
     <!-- Special Parameters -->
     |MaterialTable_MaxWidth=300px
    |displayClasses={{{displayClasses|}}}
     |MaterialTable_MaxWidth=250px
     |MaterialTable_Title={{PAGENAME}}
     |MaterialTable_Title={{PAGENAME}}


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     <!-- Structure -->
     <!-- Structure -->
     |MolecularStructureCaption=Molecular structure of melatonin
     |MolecularStructureCaption=Chemical structure of Melatonin
     |SkeletalImageFile=File:Melatonin.png
     |SkeletalImageFile=File:Melatonin.svg
     |SkeletalImageWidth=300px
     |SkeletalImageWidth=245px
     |3DImageFile=File:Melatonin_molecule_ball.png
     |3DImageFile=
     |3DImageWidth=250px
     |3DImageWidth=


     <!-- Nomenclature -->
     <!-- Nomenclature -->
     |NameCommon=Melatonin
     |NameCommon=[[common name::Melatonin]]
     |NameSubstitution=N-acetyl-5-methoxy tryptamine
     |NameSubstitution=N-Acetyl-5-methoxytryptamine
     |NameSystematic=N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide
     |NameSystematic=N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide


     <!-- Class Membership -->
     <!-- Class Membership -->
     |EffectClass=[[psychoactive class::Sedative]], [[psychoactive class::Oneirogen]]
     |EffectClass=[[psychoactive class::Oneirogen]]
     |ChemicalClass=[[chemical class::Tryptamine]]
     |ChemicalClass=[[chemical class::Tryptamine]]


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     |OralROA=true
     |OralROA=true
     |OralROA_Collapsed=false
     |OralROA_Collapsed=false
     |OralROA_Caption='''WARNING:''' Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. <u>[[responsible drug use|See responsible use section]].</u><br> '''[[Disclaimer|DISCLAIMER]]:''' PW's [[dosage]] information is gathered from users and [[Network|resources]] for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
     |OralROA_Caption=
    |OralROA_Bioavailability=
    |OralROA_Bioavailability=[[Oral min bioavailability::15]]%%<ref>{{cite journal | vauthors=((DeMuro, R. L.)), ((Nafziger, A. N.)), ((Blask, D. E.)), ((Menhinick, A. M.)), ((Bertino, J. S.)) | journal=The Journal of Clinical Pharmacology | title=The Absolute Bioavailability of Oral Melatonin | volume=40 | issue=7 | pages=781–784 | date= July 2000 | url=http://doi.wiley.com/10.1177/00912700022009422 | issn=00912700 | doi=10.1177/00912700022009422}}</ref>
     |OralROA_Threshold=[[Oral threshold dose::0.25]] - 1 [[Oral dose units::mg]]
     |OralROA_Threshold=[[Oral threshold dose::0.25]] [[Oral dose units::mg]]
     |OralROA_Light=[[Oral min light dose::1]] - [[Oral max light dose::3]] mg
     |OralROA_Light=[[Oral min light dose::0.5]] - [[Oral max light dose::1]] mg
     |OralROA_Common=[[Oral min common dose::3]] - [[Oral max common dose::5]] mg
     |OralROA_Common=[[Oral min common dose::1]] - [[Oral max common dose::3]] mg
     |OralROA_Strong=[[Oral min strong dose::5]] - [[Oral max strong dose::6]] mg
     |OralROA_Strong=[[Oral min strong dose::3]] - [[Oral max strong dose::6]] mg
     |OralROA_Heavy=[[Oral heavy dose::6]] mg +
     |OralROA_Heavy=[[Oral heavy dose::6]] mg +
     |OralROA_TimelineFile=
     |OralROA_TimelineFile=
     |OralROA_TimelineWidth=
     |OralROA_TimelineWidth=
     |OralROA_Duration=[[Oral min total time::6]] - [[Oral max total time::8]] [[Oral peak time units::hours]]
     |OralROA_Duration=[[Oral min total time::3]] - [[Oral max total time::6]] [[Oral total time units::hours]]
     |OralROA_Onset=[[Oral min onset time::30]] - [[Oral max onset time::90]] [[Oral onset time units::minutes]]
     |OralROA_Onset=[[Oral min onset time::5]] - [[Oral max onset time::20]] [[Oral onset time units::minutes]]
     |OralROA_Peak=
    |OralROA_Comeup=[[Oral min comeup time::20]] - [[Oral max comeup time::70]] [[Oral comeup time units::minutes]]
     |OralROA_Offset=
     |OralROA_Peak=[[Oral min peak time::1]] - [[Oral max peak time::2]] [[Oral peak time units::hours]]
     |OralROA_Offset=[[Oral min offset time::2]] - [[Oral max offset time::3]] [[Oral offset time units::hours]]
     |OralROA_Aftereffects=
     |OralROA_Aftereffects=


}}
}}

Latest revision as of 06:19, 15 January 2025

SubstanceBox/Melatonin
Chemical Nomenclature
Common names Melatonin
Substitutive name N-Acetyl-5-methoxytryptamine
Systematic name N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide
Class Membership
Psychoactive class Oneirogen
Chemical class Tryptamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



⇣ Oral
Dosage
Bioavailability 15%%[1]
Threshold 0.25 mg
Light 0.5 - 1 mg
Common 1 - 3 mg
Strong 3 - 6 mg
Heavy 6 mg +
Duration
Total 3 - 6 hours
Onset 5 - 20 minutes
Come up 20 - 70 minutes
Peak 1 - 2 hours
Offset 2 - 3 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

  1. ↑ DeMuro, R. L., Nafziger, A. N., Blask, D. E., Menhinick, A. M., Bertino, J. S. (July 2000). "The Absolute Bioavailability of Oral Melatonin". The Journal of Clinical Pharmacology. 40 (7): 781–784. doi:10.1177/00912700022009422. ISSN 0091-2700. 
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