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'''3-HO-2'-Oxo-PCE''' (commonly known as '''HXE''') is a novel [[dissociative]] substance of the [[arylcyclohexylamine]] class that produces [[ketamine]]-like [[dissociative]] effects when [[administered]]. It is structurally related to [[Methoxetamine]], [[Ketamine]] and [[PCE]].
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3-HO-2'-Oxo-PCE (commonly known as HXE) is a [[dissociative]] substance of the [[arylcyclohexylamine]] class that produces [[ketamine]]-like [[dissociative]] effects when [[administered]]. It is structurally related to [[Methoxetamine]],[[Ketamine]] and [[PCE]].
Limited data exists about the pharmacological properties, metabolism, and toxicity of HXE in humans, and it has a limited history of human use. It is highly advised to use harm reduction practices if using this substance.
Limited data exists about the pharmacological properties, metabolism, and toxicity of HXE in humans, and it has a limited history of human use. It is highly advised to use harm reduction practices if using this substance.
==History and culture==
==History and culture==
HXE first appeared for sale on the online research chemical market in late 2020.
HXE first appeared for sale on the online research chemical market in late 2020. However, it has been announced about three years prior where it has been 'hyped' for a long time but was on hold due to synthesis difficulties.{{citation needed}}
==Chemistry==
==Chemistry==
HXE or 2-(Ethylamino)-2-(3-hydroxyphenyl)cyclohexan-1-one is classed as an Arylcyclohexylamine
HXE or 2-(Ethylamino)-2-(3-hydroxyphenyl)cyclohexan-1-one is classed as an [[Arylcyclohexylamine]]
It is substituted on the cyclohexane ring with an oxygen at the 2' position and a hydroxy group at the 3 position on the phenyl ring. In contrast, [[MXE]] is substituted there with a methoxy group.
==Pharmacology==
==Pharmacology==
Very little is known about the pharmacology about this substance, however as an arylcyclohexamine it is reasonable to assume that it is an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “k-hole.”
Very little is known about the pharmacology about this substance, however as an arylcyclohexamine it is reasonable to assume that it is an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “k-hole.”
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{{EffectStub}}
{{EffectStub}}
{{Preamble/SubjectiveEffects}}
{{Preamble/SubjectiveEffects}}
HXE's effects resemble rather the effects of [[MXPr]], [[MXE]], [[DCK]] than more chaotic derivatives like [[O-PCE]] or [[MXiPr]]. Compared to [[MXE]], it has less of a warmth to it and is weaker in its euphoria and clearheadedness, which can roughly be considered equal to [[MXPr]]'s potency.
{{effects/base
{{effects/base
|{{effects/physical|
|{{effects/physical|
If applicable, a brief paragraph summary of the substance's physical effects may be included here.
You may select physical effects to add below [[Subjective effect index#Physical effects|here]].
*'''[[Effect::Stimulation]]''' or '''[[Effect::Sedation]]''' - HXE has a mild stimulating effect which promotes activities like socializing or moving. Higher doses will evidently lead to greater amounts of sedation as moving around can become difficult. However, there are some stimulating effects that persist at higher dosages as well.
*'''[[Effect::Spontaneous physical sensations]]''' - The body feeling of HXE can be described as slightly warm, but also empty or rough at times.
*'''[[Effect::Dizziness]]''' - This effect is usually uncommon.
*'''[[Effect::Gait alteration]]'''
*'''[[Effect::Perfection of bodily lightness]]''' - This creates the sensation that the body is floating and has become entirely weightless. This effect is strangely stimulating and encourages physical activities at low to moderate doses by making the body feel light and effortless to move.
*'''[[Effect::Motor control loss]]''' - A loss of gross and fine motor control alongside balance and coordination is prevalent within HXE and becomes especially strong at higher doses, although this compound seems to be less susceptiblw to this. This means that one should be sitting down before the onset (unless experienced) in the case of falling over and injuring oneself.
*'''[[Effect::Spatial disorientation]]'''
*'''[[Effect::Tactile suppression]]''' - This partially to entirely suppresses one's sense of touch, creating feelings of numbness within the extremities. It is responsible for the anesthetic properties of this substance.
*'''[[Effect::Pain relief]]'''
*'''[[Effect::Physical autonomy]]'''
*'''[[Effect::Nausea]]''' - High dose HXE experience can sometimes result in nausea and vomiting at the peak of the trip. For most people, this is surprisingly not as unpleasant as they would initially expect due to the accompanying detachment from the physical senses.
*'''[[Effect::Optical sliding]]'''
*'''[[Effect::Orgasm suppression]]''' - Orgasm enhancement can also be present, even at higher doses.
*'''[[Effect::Physical effect]]'''
}}
*'''[[Effect::Physical effect2]]'''
*'''[[Effect::Physical effect3]]'''
}}
{{effects/visual|
{{effects/visual|
If applicable, a brief paragraph summary of the substance's visual effects may be included here.
====Suppression====
*'''[[Effect::Visual acuity suppression]]'''
You may select visual effects to add below [[Subjective effect index#Visual effects|here]].
*'''[[Effect::Double vision]]''' - This component is prevalent at moderate to heavy doses and makes reading impossible unless one closes an eye.
*'''[[Effect::Pattern recognition suppression]]''' - This effect generally occurs at higher doses and makes one unable to recognize and interpret perceivable visual data.
====Enhancements====
*'''[[Effect::Frame rate suppression]]'''
*'''[[Effect::Visual acuity effect1]]'''
====Distortions====
====Distortions====
*'''[[Effect::Visual distortion effect1]]'''
*'''[[Effect::Perspective distortions]]'''
*'''[[Effect::Environmental cubism]]'''
*'''[[Effect::Environmental orbism]]'''
*'''[[Effect::Scenery slicing]]'''
====[[Effect::Geometry]]====
====[[Effect::Geometry]]====
If applicable, a brief paragraph summary describing the visual geometry produced by the substance may be included here.
The visual geometry found within HXE can be described as very dark and bland when compared to that of [[ketamine]] or [[DXM]] and often consists of many tiny interlocking and woven lines. It does not extend beyond level 4 and can be comprehensively described through its [[Visual_effects:_Geometry#Variations|variations]] as simplistic in complexity, algorithmic in style, synthetic in feel, unstructured in organization, dimly lit in lighting, multicolored in scheme, glossy in shading, soft in edges, small in size, slow in speed, smooth in motion, equal in rounded and angular corners, immersive in-depth and consistent in intensity.
====Hallucinatory states====
====Hallucinatory states====
If applicable, a brief summary of the substance's visual effects profile may be written here.
At high doses, HXE can produce a full range of high level hallucinatory states in a fashion that is less consistent and reproducible than that of many other commonly used [[psychedelic]]s. These effects include:
*'''[[Effect::Hallucinatory states1]]'''
*'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'') - In comparison to other [[dissociative]]s, this effect can occur at heavy doses, but is considerably less common than the same effect found within [[psychedelic]]s and [[deliriant]]s. It can be comprehensively described through its [[Visual_effects:_Internal_hallucinations#Variations|variations]] as delirious in believability, fixed in style, equal in new experiences and memory replays in content, autonomous in controllability and solid in style.
*'''[[Effect::External hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'') - In comparison to other [[dissociative]]s, this effect can occur at heavy doses, but is extremely infrequent in comparison to the same effect found within [[deliriant]]s. It can be comprehensively described through its [[Visual_effects:_Internal_hallucinations#Variations|variations]] as delirious in believability, autonomous in controllability and solid in style. The most common theme for this effect to follow is one of experiencing and talking to friends when they are not actually present.
}}
|{{effects/cognitive|
}}|
If applicable, a brief paragraph summary of the substance's cognitive effects may be included here.
You may select from a list of cognitive effects to add below [[Subjective effect index#Cognitive effects|here]].
{{effects/cognitive|
HXE is generally considered to be euphoric and comfortable. It can also turn mildly confusing, although it's manageable and not nearly as wild as [[O-PCE]] or [[MXiPr]]. It is mostly clear-headed in comparison to that of [[DXM]] and [[ketamine]]. The specific cognitive effects can be broken down into several separate subcomponents which are listed and described below:
*'''[[Effect::Cognitive effect1]]'''
*'''[[Effect::Amnesia]]'''
*'''[[Effect::Cognitive effect2]]'''
*'''[[Effect::Anxiety suppression]]'''
*'''[[Effect::Cognitive effect3]]'''
*'''[[Effect::Cognitive euphoria]]'''
*'''[[Effect::Compulsive redosing]]'''
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Creativity enhancement]]'''
*'''[[Effect::Decreased libido]]''' - This is not experienced in all environments, as [[Effect::increased libido]] may also be experienced especially at lower dosage ranges.
*'''[[Effect::Déjà vu]]'''
*'''[[Effect::Depersonalization]]
*'''[[Effect::Derealization]]
*'''[[Effect::Disinhibition]]'''
*'''[[Effect::Dream potentiation]]'''
*'''[[Effect::Ego death]]'''
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::analysis suppression]]
*'''[[Effect::Introspection]]'''
*'''[[Effect::Mania]]''' - This can potentially occur with users who are compulsively and regularly consuming large amounts of this compound. This effect occurs less often on HXE than it does on more stimulating dissociatives such as [[3-MeO-PCP]] or [[2'-Oxo-PCE]].
*'''[[Effect::Memory suppression]]'''
*'''[[Effect::Personal meaning enhancement]]'''
*'''[[Effect::Thought deceleration]]'''
*'''[[Effect::Time distortion]]'''
}}
}}
{{effects/auditory|
{{effects/auditory|
If applicable, a brief paragraph summary of the substance's auditory effects may be included here.
You may select from a list of auditory effects to add below [[Subjective effect index#Auditory effects|here]].
If applicable, a brief paragraph summary of the substance's multisensory effects may be included here.
You may select from a list of multisensory effects to add below [[Subjective effect index#Multisensory effects|here]].
{{effects/disconnective|
*'''[[Effect::Tactile disconnection]]'''
*'''[[Effect::Visual disconnection]]''' - This eventually results in HXE's equivalent of the "k-hole" or more specifically, ''[[Visual disconnection#Holes, spaces and voids|holes, spaces and voids]]'' alongside of ''[[Visual disconnection#Structures|structures]]''.
*'''[[Effect::Consciousness disconnection]]'''
*'''[[Effect::Multisensory effect1]]'''
}}
*'''[[Effect::Multisensory effect2]]'''
}}
{{effects/transpersonal|
{{effects/transpersonal|
If applicable, a brief paragraph summary of the substance's transpersonal effects may be included here.
*'''[[Effect::Existential self-realization]]'''
*'''[[Effect::Unity and interconnectedness]]'''
You may select from a list of transpersonal effects to add below [[Subjective effect index#Transpersonal effects|here]].
*'''[[Effect::Transpersonal effect1]]'''
*'''[[Effect::Transpersonal effect2]]'''
}}
}}
}}
}}
===Experience reports===
===Experience reports===
There are currently {{#ask:[[Category:SUBSTANCE]][[Category:Experience]] | format=count}} experience reports which describe the effects of this substance in our [[experience index]].
There are currently {{#ask:[[Category:HXE]][[Category:Experience]] | format=count}} experience reports which describe the effects of this substance in our [[experience index]].
* [https://www.erowid.org/experiences/subs/exp_SUBSTANCE.shtml Erowid Experience Vaults: SUBSTANCE] <!-- Check the link to see if it exists -->
* [https://www.erowid.org/experiences/subs/exp_SUBSTANCE.shtml Erowid Experience Vaults: SUBSTANCE] <!-- Check the link to see if it exists ->
-->
==Toxicity and harm potential==
==Toxicity and harm potential==
{{toxicity}}
{{toxicity}}
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It is strongly recommended that one use [[responsible use|harm reduction practices]] when using this substance.
It is strongly recommended that one use [[responsible use|harm reduction practices]] when using this substance.
===Lethal dosage===
===Lethal dosage===
The lethal dosage of HXE is not known. Based on it's effect it could probably be assumed, that it might carry roughly the same risk of death like similar compounds like [[DMXE]] or [[MXPr]].
===Tolerance and addiction potential===
===Tolerance and addiction potential===
As with other nmda receptor antagonists, the chronic use of HXE can be considered [[addiction potential::moderately addictive with a high potential for abuse]] and is capable of producing psychological dependence among certain users.
when addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage.
tolerance to many of the effects of HXE [[time to full tolerance::develops with prolonged and repeated use]].
this results in users having to administer increasingly large doses to achieve the same effects.
after that, it takes about [[time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption).
HXE presents cross-tolerance with [[cross-tolerance::all [[dissociative]]s]], meaning that after the consumption of HXE all [[dissociative]]s will have a reduced effect.
===Dangerous interactions===
===Dangerous interactions===
{{DangerousInteractions}}
{{DangerousInteractions}}
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==Legal status==
==Legal status==
{{LegalStub}}
{{LegalStub}}
*'''Switzerland:''' HXE can be considered a specially defined derivative of PCE or O-PCE and is therefore illegal.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
*'''United Kingdom''': HXE is illegal in the United Kingdom.{{citation needed}}
*'''United States''': HXE is not illegal, however, if it is sold with the intention for human consumption (such as in capsules) it becomes illegal to possess under the Federal Analogue Act. This is avoided by placing the label "not for human consumption" on the container of the chemical.{{citation needed}}
It may contain incorrect information, particularly with respect to dosage, duration, subjective effects, toxicity and other risks. It may also not meet PW style and grammar standards.
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Limited data exists about the pharmacological properties, metabolism, and toxicity of HXE in humans, and it has a limited history of human use. It is highly advised to use harm reduction practices if using this substance.
HXE first appeared for sale on the online research chemical market in late 2020. However, it has been announced about three years prior where it has been 'hyped' for a long time but was on hold due to synthesis difficulties.[citation needed]
Chemistry
HXE or 2-(Ethylamino)-2-(3-hydroxyphenyl)cyclohexan-1-one is classed as an Arylcyclohexylamine
It is substituted on the cyclohexane ring with an oxygen at the 2' position and a hydroxy group at the 3 position on the phenyl ring. In contrast, MXE is substituted there with a methoxy group.
Pharmacology
Very little is known about the pharmacology about this substance, however as an arylcyclohexamine it is reasonable to assume that it is an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “k-hole.”
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
HXE's effects resemble rather the effects of MXPr, MXE, DCK than more chaotic derivatives like O-PCE or MXiPr. Compared to MXE, it has less of a warmth to it and is weaker in its euphoria and clearheadedness, which can roughly be considered equal to MXPr's potency.
Physical effects
Stimulation or Sedation - HXE has a mild stimulating effect which promotes activities like socializing or moving. Higher doses will evidently lead to greater amounts of sedation as moving around can become difficult. However, there are some stimulating effects that persist at higher dosages as well.
Spontaneous physical sensations - The body feeling of HXE can be described as slightly warm, but also empty or rough at times.
Perfection of bodily lightness - This creates the sensation that the body is floating and has become entirely weightless. This effect is strangely stimulating and encourages physical activities at low to moderate doses by making the body feel light and effortless to move.
Motor control loss - A loss of gross and fine motor control alongside balance and coordination is prevalent within HXE and becomes especially strong at higher doses, although this compound seems to be less susceptiblw to this. This means that one should be sitting down before the onset (unless experienced) in the case of falling over and injuring oneself.
Tactile suppression - This partially to entirely suppresses one's sense of touch, creating feelings of numbness within the extremities. It is responsible for the anesthetic properties of this substance.
Nausea - High dose HXE experience can sometimes result in nausea and vomiting at the peak of the trip. For most people, this is surprisingly not as unpleasant as they would initially expect due to the accompanying detachment from the physical senses.
Double vision - This component is prevalent at moderate to heavy doses and makes reading impossible unless one closes an eye.
Pattern recognition suppression - This effect generally occurs at higher doses and makes one unable to recognize and interpret perceivable visual data.
The visual geometry found within HXE can be described as very dark and bland when compared to that of ketamine or DXM and often consists of many tiny interlocking and woven lines. It does not extend beyond level 4 and can be comprehensively described through its variations as simplistic in complexity, algorithmic in style, synthetic in feel, unstructured in organization, dimly lit in lighting, multicolored in scheme, glossy in shading, soft in edges, small in size, slow in speed, smooth in motion, equal in rounded and angular corners, immersive in-depth and consistent in intensity.
Hallucinatory states
At high doses, HXE can produce a full range of high level hallucinatory states in a fashion that is less consistent and reproducible than that of many other commonly used psychedelics. These effects include:
HXE is generally considered to be euphoric and comfortable. It can also turn mildly confusing, although it's manageable and not nearly as wild as O-PCE or MXiPr. It is mostly clear-headed in comparison to that of DXM and ketamine. The specific cognitive effects can be broken down into several separate subcomponents which are listed and described below:
Mania - This can potentially occur with users who are compulsively and regularly consuming large amounts of this compound. This effect occurs less often on HXE than it does on more stimulating dissociatives such as 3-MeO-PCP or 2'-Oxo-PCE.
There are currently 0 experience reports which describe the effects of this substance in our experience index.
Toxicity and harm potential
This toxicity and harm potential section is a stub.
As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.
The toxicity and long-term health effects of recreational HXE use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because HXE has very little history of human usage.
The lethal dosage of HXE is not known. Based on it's effect it could probably be assumed, that it might carry roughly the same risk of death like similar compounds like DMXE or MXPr.
Tolerance and addiction potential
As with other nmda receptor antagonists, the chronic use of HXE can be considered moderately addictive with a high potential for abuse and is capable of producing psychological dependence among certain users.
when addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.
tolerance to many of the effects of HXE develops with prolonged and repeated use.
this results in users having to administer increasingly large doses to achieve the same effects.
after that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption).
HXE presents cross-tolerance with [[cross-tolerance::all dissociatives]], meaning that after the consumption of HXE all dissociatives will have a reduced effect.
Warning:Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
As such, it may contain incomplete or wrong information. You can help by expanding it.
Switzerland: HXE can be considered a specially defined derivative of PCE or O-PCE and is therefore illegal.[1]
United Kingdom: HXE is illegal in the United Kingdom.[citation needed]
United States: HXE is not illegal, however, if it is sold with the intention for human consumption (such as in capsules) it becomes illegal to possess under the Federal Analogue Act. This is avoided by placing the label "not for human consumption" on the container of the chemical.[citation needed]
