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Template:SubstanceBox/Pregabalin: Difference between revisions

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>Oskykins
m Text replacement - "PW's dosage information is a summary of data gathered from users and resources. It is not a recommendation and should be verified with other sources for accuracy." to "PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy."
>Isaak
Adjust the total such that it is the sum of onset, comeup, peak and offset for the min and max respectively.
 
(40 intermediate revisions by 16 users not shown)
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{{SubstanceBox
{{SubstanceBox


     <!-- Table Properties -->
     <!-- Special Parameters -->
     |MaterialTable_MaxWidth=230px
    |displayClasses={{{displayClasses|}}}
     |MaterialTable_MaxWidth=250px
     |MaterialTable_Title={{PAGENAME}}
     |MaterialTable_Title={{PAGENAME}}


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     |ModuleStructure=true
     |ModuleStructure=true
     |ModuleNomenclature=true
     |ModuleNomenclature=true
    |ModuleClassMembership=true
     |ModuleROA=true
     |ModuleROA=true


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     <!-- Structure -->
     <!-- Structure -->
     |MolecularStructureCaption=The skeletal formula of pregabalin
     |MolecularStructureCaption=Molecular structure of pregabalin
     |SkeletalImageFile=File:220px-Pregabalin.svg.png
     |SkeletalImageFile=File:Pregabalin.svg
     |SkeletalImageWidth=220px
     |SkeletalImageWidth=245px
     |3DImageFile=File:1024px-Pregabalin ball-and-stick.png
     |3DImageFile=
     |3DImageWidth=220px
     |3DImageWidth=


     <!-- Nomenclature -->
     <!-- Nomenclature -->
     |NameCommon=Lyrica, Nervalin, Pregabalin
     |NameCommon=[[common name::Pregabalin]], [[common name::Lyrica]], [[common name::Nervalin]]
     |NameSubstitution=
     |NameSubstitution=3-Isobutyl GABA
     |NameSystematic=(S)-3-(aminomethyl)-5-methylhexanoic acid
     |NameSystematic=(S)-3-(Aminomethyl)-5-methylhexanoic acid
 
    <!-- Class Membership -->
    |EffectClass=[[psychoactive class::Depressant]]
    |ChemicalClass=[[chemical class::Gabapentinoid]]


     <!-- Dosage/Duration -->
     <!-- Dosage/Duration -->
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     |SmokedROA=false
     |SmokedROA=false
     |SmokedROA_Collapsed=true
     |SmokedROA_Collapsed=true
     |SmokedROA_Caption='''WARNING:''' Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. <u>[[responsible use|See responsible use section]].</u><br> '''[[Disclaimer|DISCLAIMER]]:''' PW's [[dosage]] information is gathered from users and [[Network|resources]] for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
     |SmokedROA_Caption=
     |SmokedROA_Bioavailability=
     |SmokedROA_Bioavailability=
     |SmokedROA_Threshold=< x mg
     |SmokedROA_Threshold=< x mg
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     |SmokedROA_Peak=x minutes
     |SmokedROA_Peak=x minutes
     |SmokedROA_Offset=x hours
     |SmokedROA_Offset=x hours
     |SmokedROA_Afterglow=x hours
     |SmokedROA_Aftereffects=x hours


     |OralROA=true
     |OralROA=true
     |OralROA_Collapsed=false
     |OralROA_Collapsed=false
     |OralROA_Caption='''WARNING:''' Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. <u>[[responsible use|See responsible use section]].</u><br> '''[[Disclaimer|DISCLAIMER]]:''' PW's [[dosage]] information is gathered from users and [[Network|resources]] for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
     |OralROA_Caption='''WARNING:''' Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. <u>[[responsible drug use|See responsible use section]].</u><br> '''[[Disclaimer|DISCLAIMER]]:''' PW's [[dosage]] information is gathered from users and [[Network|resources]] for educational purposes only. It is not a recommendation.<br>'''This dosage and duration information has been sourced from [http://drugs.tripsit.me/pregabalin TripSit]'''
     |OralROA_Bioavailability=90%
     |OralROA_Bioavailability=[[Oral min bioavailability::]] ~[[Oral max bioavailability::90]]%<ref name="Bockbrader2010">{{cite journal | vauthors=((Bockbrader, H. N.)), ((Radulovic, L. L.)), ((Posvar, E. L.)), ((Strand, J. C.)), ((Alvey, C. W.)), ((Busch, J. A.)), ((Randinitis, E. J.)), ((Corrigan, B. W.)), ((Haig, G. M.)), ((Boyd, R. A.)), ((Wesche, D. L.)) | journal=The Journal of Clinical Pharmacology | title=Clinical Pharmacokinetics of Pregabalin in Healthy Volunteers | volume=50 | issue=8 | pages=941–950 | date= August 2010 | url=http://doi.wiley.com/10.1177/0091270009352087 | issn=00912700 | doi=10.1177/0091270009352087}}</ref>
     |OralROA_Threshold=[[Oral threshold dose::75]]-150 [[Oral dose units::mg]]
     |OralROA_Threshold=[[Oral threshold dose::50]] [[Oral dose units::mg]]
     |OralROA_Light=[[Oral min light dose::150]] - [[Oral max light dose::300]] mg
     |OralROA_Light=[[Oral min light dose::50]] - [[Oral max light dose::225]] mg
     |OralROA_Common=[[Oral min common dose::300]] - [[Oral max common dose::600]] mg
     |OralROA_Common=[[Oral min common dose::225]] - [[Oral max common dose::600]] mg
     |OralROA_Strong=[[Oral min strong dose::600]] - [[Oral max strong dose::900]] mg
     |OralROA_Strong=[[Oral min strong dose::600]] - [[Oral max strong dose::900]] mg
     |OralROA_Heavy= > [[Oral heavy dose::900]] mg
     |OralROA_Heavy= [[Oral heavy dose::900]] mg +
     |OralROA_TimelineFile=
     |OralROA_TimelineFile=
     |OralROA_TimelineWidth=
     |OralROA_TimelineWidth=
     |OralROA_Duration=[[Oral min total time::4]] - [[Oral max total time::6]] [[Oral total time units::hours]]
     |OralROA_Duration=[[Oral min total time::9]] - [[Oral max total time::17]] [[Oral total time units::hours]]
     |OralROA_Onset=[[Oral min onset time::60]] - [[Oral max onset time::90]] [[Oral onset time units::minutes]]
     |OralROA_Onset=[[Oral min onset time::30]] - [[Oral max onset time::45]] [[Oral onset time units::minutes]]
     |OralROA_Peak=
    |OralROA_Comeup=[[Oral min comeup time::1]] - [[Oral max comeup time::2]] [[Oral comeup time units::hours]]
     |OralROA_Offset=
     |OralROA_Peak=[[Oral min peak time::4]] - [[Oral max peak time::6]] [[Oral peak time units::hours]]
     |OralROA_Afterglow=
     |OralROA_Offset=[[Oral min offset time::4]] - [[Oral max offset time::8]] [[Oral offset time units::hours]]
     |OralROA_Aftereffects=[[Oral min afterglow time::4]] - [[Oral max afterglow time::10]] [[Oral afterglow time units::hours]]
 
|RectalROA=true
    |RectalROA_Collapsed=true
    |RectalROA_Caption='''WARNING:''' Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. <u>[[responsible drug use|See responsible use section]].</u><br> '''[[Disclaimer|DISCLAIMER]]:''' PW's [[dosage]] information is gathered from users and [[Network|resources]] for educational purposes only. It is not a recommendation.<br>'''This dosage and duration information has been sourced from [http://drugs.tripsit.me/methamphetamine TripSit]'''
    |RectalROA_Bioavailability=~99%
    |RectalROA_Threshold=< [[Rectal threshold dose::40]] [[Rectal dose units::mg]]
    |RectalROA_Light=[[Rectal min light dose::40]] - [[Rectal max light dose::200]] mg
    |RectalROA_Common=[[Rectal min common dose::200]] - [[Rectal max common dose::450]] mg
    |RectalROA_Strong=[[Rectal min strong dose::450]] - [[Rectal max strong dose::600]] mg
    |RectalROA_Heavy=[[Rectal heavy dose::600]] mg+
    |RectalROA_TimelineFile=
    |RectalROA_TimelineWidth=280px
    |RectalROA_Duration=[[Rectal min total time::5]] - [[Rectal max total time::8]] [[Rectal total time units::hours]]
    |RectalROA_Onset=[[Rectal min onset time::15]] - [[Rectal max onset time::30]] [[Rectal onset time units::minutes]]
    |RectalROA_Comeup=[[Rectal min comeup time::30]] - [[Rectal max comeup time::120]] [[Rectal comeup time units::minutes]]
    |RectalROA_Peak=[[Rectal min peak time::2]] - [[Rectal max peak time::3]] [[Rectal peak time units::hours]]
    |RectalROA_Offset=[[Rectal min offset time::3]] - [[Rectal max offset time::5]] [[Rectal offset time units::hours]]
    |RectalROA_Aftereffects=[[Rectal min afterglow time::6]] - [[Rectal max afterglow time::12]] [[Rectal afterglow time units::hours]]


}}
}}

Latest revision as of 07:26, 13 October 2022

SubstanceBox/Pregabalin
Chemical Nomenclature
Common names Pregabalin, Lyrica, Nervalin
Substitutive name 3-Isobutyl GABA
Systematic name (S)-3-(Aminomethyl)-5-methylhexanoic acid
Class Membership
Psychoactive class Depressant
Chemical class Gabapentinoid
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



⇣ Oral
Dosage
Bioavailability ~90%[1]
Threshold 50 mg
Light 50 - 225 mg
Common 225 - 600 mg
Strong 600 - 900 mg
Heavy 900 mg +
Duration
Total 9 - 17 hours
Onset 30 - 45 minutes
Come up 1 - 2 hours
Peak 4 - 6 hours
Offset 4 - 8 hours
After effects 4 - 10 hours




⇣ Rectal
Dosage
Bioavailability ~99%
Threshold < 40 mg
Light 40 - 200 mg
Common 200 - 450 mg
Strong 450 - 600 mg
Heavy 600 mg+
Duration
Total 5 - 8 hours
Onset 15 - 30 minutes
Come up 30 - 120 minutes
Peak 2 - 3 hours
Offset 3 - 5 hours
After effects 6 - 12 hours





DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

  1. ↑ Bockbrader, H. N., Radulovic, L. L., Posvar, E. L., Strand, J. C., Alvey, C. W., Busch, J. A., Randinitis, E. J., Corrigan, B. W., Haig, G. M., Boyd, R. A., Wesche, D. L. (August 2010). "Clinical Pharmacokinetics of Pregabalin in Healthy Volunteers". The Journal of Clinical Pharmacology. 50 (8): 941–950. doi:10.1177/0091270009352087. ISSN 0091-2700. 
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