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Template:SubstanceBox/Pregabalin: Difference between revisions

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>Isaak
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>Isaak
Adjust the total such that it is the sum of onset, comeup, peak and offset for the min and max respectively.
 
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     |OralROA_Collapsed=false
     |OralROA_Collapsed=false
     |OralROA_Caption='''WARNING:''' Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. <u>[[responsible drug use|See responsible use section]].</u><br> '''[[Disclaimer|DISCLAIMER]]:''' PW's [[dosage]] information is gathered from users and [[Network|resources]] for educational purposes only. It is not a recommendation.<br>'''This dosage and duration information has been sourced from [http://drugs.tripsit.me/pregabalin TripSit]'''
     |OralROA_Caption='''WARNING:''' Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. <u>[[responsible drug use|See responsible use section]].</u><br> '''[[Disclaimer|DISCLAIMER]]:''' PW's [[dosage]] information is gathered from users and [[Network|resources]] for educational purposes only. It is not a recommendation.<br>'''This dosage and duration information has been sourced from [http://drugs.tripsit.me/pregabalin TripSit]'''
     |OralROA_Bioavailability=~90%<ref>https://accp1.onlinelibrary.wiley.com/doi/abs/10.1177/0091270009352087</ref>
     |OralROA_Bioavailability=[[Oral min bioavailability::]] ~[[Oral max bioavailability::90]]%<ref name="Bockbrader2010">{{cite journal | vauthors=((Bockbrader, H. N.)), ((Radulovic, L. L.)), ((Posvar, E. L.)), ((Strand, J. C.)), ((Alvey, C. W.)), ((Busch, J. A.)), ((Randinitis, E. J.)), ((Corrigan, B. W.)), ((Haig, G. M.)), ((Boyd, R. A.)), ((Wesche, D. L.)) | journal=The Journal of Clinical Pharmacology | title=Clinical Pharmacokinetics of Pregabalin in Healthy Volunteers | volume=50 | issue=8 | pages=941–950 | date= August 2010 | url=http://doi.wiley.com/10.1177/0091270009352087 | issn=00912700 | doi=10.1177/0091270009352087}}</ref>
     |OralROA_Threshold=[[Oral threshold dose::50]] [[Oral dose units::mg]]
     |OralROA_Threshold=[[Oral threshold dose::50]] [[Oral dose units::mg]]
     |OralROA_Light=[[Oral min light dose::75]] - [[Oral max light dose::225]] mg
     |OralROA_Light=[[Oral min light dose::50]] - [[Oral max light dose::225]] mg
     |OralROA_Common=[[Oral min common dose::225]] - [[Oral max common dose::600]] mg
     |OralROA_Common=[[Oral min common dose::225]] - [[Oral max common dose::600]] mg
     |OralROA_Strong=[[Oral min strong dose::600]] - [[Oral max strong dose::900]] mg
     |OralROA_Strong=[[Oral min strong dose::600]] - [[Oral max strong dose::900]] mg
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     |OralROA_TimelineFile=
     |OralROA_TimelineFile=
     |OralROA_TimelineWidth=
     |OralROA_TimelineWidth=
     |OralROA_Duration=[[Oral min total time::8]] - [[Oral max total time::14]] [[Oral total time units::hours]]
     |OralROA_Duration=[[Oral min total time::9]] - [[Oral max total time::17]] [[Oral total time units::hours]]
     |OralROA_Onset=[[Oral min onset time::40]] - [[Oral max onset time::120]] [[Oral onset time units::minutes]]
     |OralROA_Onset=[[Oral min onset time::30]] - [[Oral max onset time::45]] [[Oral onset time units::minutes]]
    |OralROA_Comeup=[[Oral min comeup time::1]] - [[Oral max comeup time::2]] [[Oral comeup time units::hours]]
     |OralROA_Peak=[[Oral min peak time::4]] - [[Oral max peak time::6]] [[Oral peak time units::hours]]
     |OralROA_Peak=[[Oral min peak time::4]] - [[Oral max peak time::6]] [[Oral peak time units::hours]]
     |OralROA_Offset=[[Oral min offset time::4]] - [[Oral max offset time::8]] [[Oral offset time units::hours]]
     |OralROA_Offset=[[Oral min offset time::4]] - [[Oral max offset time::8]] [[Oral offset time units::hours]]

Latest revision as of 07:26, 13 October 2022

SubstanceBox/Pregabalin
Chemical Nomenclature
Common names Pregabalin, Lyrica, Nervalin
Substitutive name 3-Isobutyl GABA
Systematic name (S)-3-(Aminomethyl)-5-methylhexanoic acid
Class Membership
Psychoactive class Depressant
Chemical class Gabapentinoid
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Bioavailability ~90%[1]
Threshold 50 mg
Light 50 - 225 mg
Common 225 - 600 mg
Strong 600 - 900 mg
Heavy 900 mg +
Duration
Total 9 - 17 hours
Onset 30 - 45 minutes
Come up 1 - 2 hours
Peak 4 - 6 hours
Offset 4 - 8 hours
After effects 4 - 10 hours




Rectal
Dosage
Bioavailability ~99%
Threshold < 40 mg
Light 40 - 200 mg
Common 200 - 450 mg
Strong 450 - 600 mg
Heavy 600 mg+
Duration
Total 5 - 8 hours
Onset 15 - 30 minutes
Come up 30 - 120 minutes
Peak 2 - 3 hours
Offset 3 - 5 hours
After effects 6 - 12 hours





DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

  1. Bockbrader, H. N., Radulovic, L. L., Posvar, E. L., Strand, J. C., Alvey, C. W., Busch, J. A., Randinitis, E. J., Corrigan, B. W., Haig, G. M., Boyd, R. A., Wesche, D. L. (August 2010). "Clinical Pharmacokinetics of Pregabalin in Healthy Volunteers". The Journal of Clinical Pharmacology. 50 (8): 941–950. doi:10.1177/0091270009352087. ISSN 0091-2700.