Classical psychedelics: Difference between revisions
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'''Classical psychedelics''' (or '''classic psychedelics''') refers to the most common, recognizable, and historically significant [[psychedelic]] substances. They generally include: | |||
* [[DMT]] (or [[Ayahuasca]]) | |||
* [[LSD]] | |||
* [[Mescaline]] | |||
* [[Psilocybin mushrooms]] | |||
A common feature of classical psychedelics is that they act as (partial) [[agonist]]s at the [[serotonin]] 5-HT<sub>2A</sub> [[receptor]], which is abundant in specific regions of the human brain.<ref>Carhart-Harris | A common feature of classical psychedelics is that they act as (partial) [[agonist]]s at the [[serotonin]] 5-HT<sub>2A</sub> [[receptor]], which is abundant in specific regions of the human brain.<ref>{{cite journal | vauthors=((Carhart-Harris, R. L.)), ((Leech, R.)), ((Hellyer, P. J.)), ((Shanahan, M.)), ((Feilding, A.)), ((Tagliazucchi, E.)), ((Chialvo, D. R.)), ((Nutt, D.)) | journal=Frontiers in Human Neuroscience | title=The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs | volume=8 | date= 2014 | url=http://journal.frontiersin.org/article/10.3389/fnhum.2014.00020/abstract | issn=1662-5161 | doi=10.3389/fnhum.2014.00020}}</ref><ref>{{cite journal | vauthors=((Glennon, R. A.)), ((Titeler, M.)), ((McKenney, J. D.)) | journal=Life Sciences | title=Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents | volume=35 | issue=25 | pages=2505–2511 | date= December 1984 | url=https://linkinghub.elsevier.com/retrieve/pii/0024320584904363 | issn=00243205 | doi=10.1016/0024-3205(84)90436-3}}</ref> | ||
Classical psychedelics may be distinguished from novel psychedelics, which are generally psychedelics discovered after the 1970s. These include relatively older and well-tested substances like 2C-B as well as highly novel compounds like the [[25x-NBOMe]] series, which were developed as neurochemical probes. | |||
Furthermore, they are thought to have excellent safety profiles relative to most [[psychoactive substances]], with low abuse potential and toxicity.{{citation needed}} However, adverse psychological reactions like severe [[anxiety]], [[paranoia]], [[delusions]], [[mania]], and [[psychosis]] are always possible, especially in individuals susceptible to mental disorders. | |||
As a result, [[harm reduction practices]] are advised. | |||
== See also == | == See also == | ||
Latest revision as of 21:50, 29 June 2022
Classical psychedelics (or classic psychedelics) refers to the most common, recognizable, and historically significant psychedelic substances. They generally include:
A common feature of classical psychedelics is that they act as (partial) agonists at the serotonin 5-HT2A receptor, which is abundant in specific regions of the human brain.[1][2]
Classical psychedelics may be distinguished from novel psychedelics, which are generally psychedelics discovered after the 1970s. These include relatively older and well-tested substances like 2C-B as well as highly novel compounds like the 25x-NBOMe series, which were developed as neurochemical probes.
Furthermore, they are thought to have excellent safety profiles relative to most psychoactive substances, with low abuse potential and toxicity.[citation needed] However, adverse psychological reactions like severe anxiety, paranoia, delusions, mania, and psychosis are always possible, especially in individuals susceptible to mental disorders.
As a result, harm reduction practices are advised.
See also
References
- ↑ Carhart-Harris, R. L., Leech, R., Hellyer, P. J., Shanahan, M., Feilding, A., Tagliazucchi, E., Chialvo, D. R., Nutt, D. (2014). "The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs". Frontiers in Human Neuroscience. 8. doi:10.3389/fnhum.2014.00020. ISSN 1662-5161.
- ↑ Glennon, R. A., Titeler, M., McKenney, J. D. (December 1984). "Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents". Life Sciences. 35 (25): 2505–2511. doi:10.1016/0024-3205(84)90436-3. ISSN 0024-3205.