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'''Microdosing''' (also known as '''psychedelic microdosing''') is the practice of using sub-threshold doses of a psychedelic substance in an attempt to produce a therapeutic or [[nootropic]] effect. Microdosing has been claimed by some to have a wide range of benefits including enhancing productivity, treating symptoms of psychological disorders such as clinical depression and adult ADD/ADHD, boosting creativity and problem-solving abilities, as well as increase spiritual awareness. However, there is currently no clinical evidence to support these claims.
'''Microdosing''' (also known as '''psychedelic microdosing''') is the practice of using sub-threshold doses of a psychedelic substance in an attempt to produce a therapeutic or [[nootropic]] effect. Microdosing has been claimed by some to have a wide range of benefits including enhancing productivity, treating symptoms of psychological disorders such as clinical depression and adult ADD/ADHD, boosting creativity and problem-solving abilities, as well as increase spiritual awareness. There is currently no clinical evidence to support these claims, however a number of small scale studies have shown positive outcomes. In 2020 a study by the Beckley Foundation found that a 20 microgram dose of LSD significantly reduced pain perception when compared to a placebo, with results comparable to those observed after administration of opioids.<ref>{{Cite web|url=https://www.leafie.co.uk/psychedelics/5-things-you-need-to-know-about-microdosing/|title=5 things you need to know about microdosing|website=leafie|access-date=16 September 2021}}</ref>
While the practice has its origins with [[LSD]], it is in theory possible to microdose with any [[psychedelic]] substance. There are a growing body of reports of microdosing [[psilocybin mushrooms]], or psychedelic [[research chemicals]], particularly [[LSD]] analogs such as [[ALD-52]], [[1P-LSD]], [[AL-LAD]] and [[ETH-LAD]].
While the practice has its origins with [[LSD]], it is in theory possible to microdose with any [[psychedelic]] substance. There are a growing body of reports of microdosing [[psilocybin mushrooms]], or psychedelic [[research chemicals]], particularly [[LSD]] analogs such as [[ALD-52]], [[1P-LSD]], [[AL-LAD]] and [[ETH-LAD]].
Latest revision as of 12:38, 25 September 2021
Microdosing (also known as psychedelic microdosing) is the practice of using sub-threshold doses of a psychedelic substance in an attempt to produce a therapeutic or nootropic effect. Microdosing has been claimed by some to have a wide range of benefits including enhancing productivity, treating symptoms of psychological disorders such as clinical depression and adult ADD/ADHD, boosting creativity and problem-solving abilities, as well as increase spiritual awareness. There is currently no clinical evidence to support these claims, however a number of small scale studies have shown positive outcomes. In 2020 a study by the Beckley Foundation found that a 20 microgram dose of LSD significantly reduced pain perception when compared to a placebo, with results comparable to those observed after administration of opioids.[1]
Microdoses range from about one tenth of an active dose. A microdose of LSD is generally considered to be between 5-15 micrograms. This can be measured accurately using volumetric dosing techniques. A microdose of psilocybin mushrooms is harder to determine due to the variations in potency between species and batches; it is generally advised to start with no more than .25g.
Horsley, R.R., Páleníček, T., Kolin, J., & Valeš, K. (2018). Psilocin and ketamine microdosing: effects of subchronic intermittent microdoses in the elevated plus-maze in male Wistar rats. Behavioural Pharmacology. https://doi.org/10.1097/FBP.0000000000000394
