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| [[File:Lysergamide.png|thumb|right|261px|Substitutive structure of a ''lysergamide''.]]
| | {{Page|Lysergamides}} |
| | | [[Category:Base Structures]] |
| Amides of ''lysergic acid'' are collectively known as '''lysergamides'''.
| | [[Category:Phenethylamine]] |
| | | [[Category:Tryptamine]] |
| '''Ergoline''' refers to a class of compounds derived from alkaloids of a group of fungi known as ''Ergot'', in the ''Claviceps'' genus. These compounds typically have have strong psychedelic effects.
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| ==Chemistry==
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| {| class="wikitable mw-collapsible" | |
| |+ Lysergamides, tabulated by structure
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| |-
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| !Name !! R1 !! R6 !! R2 !! R3
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| |-
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| | [[Lysergic acid amide|LSA]] / [[Lysergic acid amide|LAA]] || H || [[Methyl|CH<sub>3</sub>]] || H || H
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| |-
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| | [[DAM-57]] || H || CH<sub>3</sub> || CH<sub>3</sub> || CH<sub>3</sub>
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| |-
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| | [[Ergometrine]] (Ergonovine) || H || CH<sub>3</sub> || CH(CH<sub>3</sub>)CH<sub>2</sub>OH || H
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| |-
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| | [[Ergotamine]] || H || CH<sub>3</sub> || -- || C<sub>17</sub>H<sub>18</sub>N<sub>2</sub>O<sub>4</sub>
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| |-
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| | [[Methergine]] || H || CH<sub>3</sub> || CH(CH<sub>2</sub>CH<sub>3</sub>)CH<sub>2</sub>OH || H
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| |-
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| | [[Methysergide]] || CH<sub>3</sub> || CH<sub>3</sub> || CH(CH<sub>2</sub>CH<sub>3</sub>)CH<sub>2</sub>OH || H
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| |-
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| | [[LAE-32]] || H || CH<sub>3</sub> || [[Ethyl group|CH<sub>2</sub>CH<sub>3</sub>]] || H
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| |-
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| | [[Lysergic acid 2-butyl amide|LSB]] || H || CH<sub>3</sub> || CH(CH<sub>3</sub>)CH<sub>2</sub>CH<sub>3</sub> || H
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| |-
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| | [[Lysergic acid 3-pentyl amide|LSP]] || H || CH<sub>3</sub> || CH(CH<sub>2</sub>CH<sub>3</sub>)CH<sub>2</sub>CH<sub>3</sub> || H
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| |-
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| | [[Diallyllysergamide|DAL]] || H || CH<sub>3</sub> || [[Allyl|H<sub>2</sub>C=CH-CH<sub>2</sub>]] || Allyl|H<sub>2</sub>C=CH-CH<sub>2</sub>
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| |-
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| | [[Methylisopropyllysergamide|MIPLA]] || H || CH<sub>3</sub> || [[Isopropyl|CH(CH<sub>3</sub>)<sub>2</sub>]] || CH<sub>3</sub>
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| |-
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| | [[Ethylisopropyllysergamide|EIPLA]] || H || CH<sub>3</sub> || CH(CH<sub>3</sub>)<sub>2</sub> || CH<sub>2</sub>CH<sub>3</sub>
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| |-
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| | [[Methylpropyllysergamide|LAMP]] || H || CH<sub>3</sub> || CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub> || CH<sub>3</sub>
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| |-
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| | '''[[LSD]]''' / [[LSD|LAD]] || H || CH<sub>3</sub> || CH<sub>2</sub>CH<sub>3</sub> || CH<sub>2</sub>CH<sub>3</sub>
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| |-
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| | [[ETH-LAD]] || H || CH<sub>2</sub>CH<sub>3</sub> || CH<sub>2</sub>CH<sub>3</sub> || CH<sub>2</sub>CH<sub>3</sub>
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| |-
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| | [[PARGY-LAD]] || H || [[Propynyl|HC≡C−CH<sub>2</sub>]] || CH<sub>2</sub>CH<sub>3</sub> || CH<sub>2</sub>CH<sub>3</sub>
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| |-
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| | [[AL-LAD]] || H || H<sub>2</sub>C=CH-CH<sub>2</sub> || CH<sub>2</sub>CH<sub>3</sub> || CH<sub>2</sub>CH<sub>3</sub>
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| |-
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| | [[PRO-LAD]] || H || [[Propyl|CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub>]] || CH<sub>2</sub>CH<sub>3</sub> || CH<sub>2</sub>CH<sub>3</sub>
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| |-
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| | [[CYP-LAD]] || H || [[Cyclopropyl|C<sub>3</sub>H<sub>5</sub>]] || CH<sub>2</sub>CH<sub>3</sub> || CH<sub>2</sub>CH<sub>3</sub>
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| |-
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| | [[BU-LAD]] || H || [[Butyl|CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub>]] || CH<sub>2</sub>CH<sub>3</sub> || CH<sub>2</sub>CH<sub>3</sub>
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| |-
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| | [[ALD-52]] || [[Acetyl|COCH<sub>3</sub>]] || CH<sub>3</sub> || CH<sub>2</sub>CH<sub>3</sub> || CH<sub>2</sub>CH<sub>3</sub>
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| |-
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| | [[MLD-41]] || CH<sub>3</sub> || CH<sub>3</sub> || CH<sub>2</sub>CH<sub>3</sub> || CH<sub>2</sub>CH<sub>3</sub>
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| |-
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| | [[LSM-775]] || H || CH<sub>3</sub> || colspan=2|[[Morpholine|CH<sub>2</sub>CH<sub>2</sub>-O-CH<sub>2</sub>CH<sub>2</sub>]]
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| |-
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| | [[LPD-824]] || H || CH<sub>3</sub> || colspan=2|[[Pyrrolidine|CH<sub>2</sub>CH<sub>2</sub>
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| CH<sub>2</sub>CH<sub>2</sub>]]
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| |-
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| | [[LSD-Pip]] || H || CH<sub>3</sub> || colspan=2|[[Piperidine|CH<sub>2</sub>CH<sub>2</sub>
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| CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>]]
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| |-
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| | [[Lysergic acid 2,4-dimethylazetidide|LA-SS-Az]] || H || CH<sub>3</sub> || colspan=2|CH<sub>2</sub>(CHCH<sub>3</sub>)<sub>2</sub>CH<sub>2</sub>
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| |}
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| ==Pharmacology==
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| Lysergamides are believed to produce their psychedelic effect primarily by partial agonism of [[Serotonin#The 5-HT System|5-HT<sub>2A</sub> receptors]].
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| ==References==
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| [[wikipedia:Lysergamides|Wikipedia]]
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| [[Category:Psychedelic]] | | [[Category:Psychedelic]] |
The main page for this category is Lysergamides
