View source for Talk:3-CMC

{{Headerpanel|{{Warning/3-CMC}}}}
{{SubstanceBox/3-CMC}}
'''3-Chloromethcathinone''' (also known as '''3-CMC''' or '''clophedrone''' <ref>WRZESIEŃ, W., STANASZEK, R., ZUBA, D., BYRSKA, B. (2018). Clandestine laboratory producing mephedrone (4-MMC) and Clephedrone (4-CMC) – substance, identification and hazard analysis, 40, 287-309. <nowiki>http://www.forensicscience.pl/pfs/115_Wrzesien_m.pdf</nowiki>.</ref>) is a novel [[psychoactive class::stimulant]]-[[psychoactive class::entactogen]] substance of the [[chemical class::cathinone]] class. It is the analogue of [[3-Chloromethamphetamine]] (3-CMA) and structurally closely related to the antidepressant and anti-addictive medication [[bupropion]]. The [[subjective effects]] are reported to be similar, but weaker, to those of 3-MMC. This mostly includes [[stimulation]], [[anxiety suppression]], [[disinhibition]], [[empathy, affection, and sociability enhancement|enhanced empathy and sociability]], [[muscle relaxation|relaxation]], [[increased libido]], and [[euphoria]]. It is also reported to be subject to [[compulsive redosing]] which can lead to [[psychosis]] and habitual use.

==History and culture==
3-CMC has been sold online on the [[research chemical]] market as a [[designer drug]] since 2013 in mainly European countries<ref>{{cite journal | vauthors = Odoardi S, Romolo FS, Strano-Rossi S | title = A snapshot on NPS in Italy: Distribution of drugs in seized materials analyzed in an Italian forensic laboratory in the period 2013-2015 | journal = Forensic Science International | volume = 265 | pages = 116–20 | date = August 2016 | pmid = 26874736 | doi = 10.1016/j.forsciint.2016.01.037 }}</ref>. 3-CMC has been marketed as the legal successor of [[3-MMC]] in the Netherlands since its ban in October 2021 <ref>[https://www.tubantia.nl/enschede/tactus-verslavingszorg-is-bezorgd-want-de-verboden-partydrug-3-mmc-heeft-al-een-legale-opvolger-3-cmc~a3acd662/ ''Tactus Verslavingszorg is bezorgd, want de verboden partydrug 3-MMC heeft al een legale opvolger: 3-CMC'']</ref>.

==Pharmacology==
The pharmacology of 3-CMC has not been fully studied, however it is known to promote the release of [[dopamine]], [[noradrenaline]] and [[serotonin]] similar to other substituted methcathinones.<ref>National Center for Biotechnology Information (2022). PubChem Bioassay Record for AID 1224711, Source: ChEMBL. Retrieved January 16, 2022 from <nowiki>https://pubchem.ncbi.nlm.nih.gov/bioassay/1224711</nowiki>.</ref> <ref>National Center for Biotechnology Information (2022). PubChem Bioassay Record for AID 1224713, Source: ChEMBL. Retrieved January 16, 2022 from <nowiki>https://pubchem.ncbi.nlm.nih.gov/bioassay/1224713</nowiki>.</ref>

==Subjective effects==
{{Preamble/SubjectiveEffects}}

{{effects/base
|{{effects/physical|

*'''[[Effect::Stimulation]]''' - The stimulation is heavily increased when combined with alcohol, however, this is not recommended due to its potential for harm. Paradoxically, the stimulation may be less pronounced at higher doses.
*'''[[Effect::Spontaneous bodily sensations]]''' 
**'''[[Effect::Physical euphoria]]''' - This is more likely to occur in higher doses, or when taken orally.
*'''[[Effect::Appetite suppression]]'''
*'''[[Effect::Teeth grinding]]'''
*'''[[Effect::Abnormal heartbeat]]'''
**'''[[Effect::Increased heart rate]]'''
**'''[[Effect::Increased blood pressure]]'''
*'''[[Effect::Vasoconstriction]]''' - This is reported to be less pronounced with an oral ROA at low - medium doses.

}}
|{{effects/cognitive|

*'''[[Effect::Cognitive euphoria]]''' - Similar to the [[physical euphoria]], this is more likely to occur in higher doses, or when taken orally.
*'''[[Effect::Compulsive redosing]]''' - Be careful if redosing this substance as it can lead to extreme cases of vasoconstriction.
*'''[[Effect::Focus enhancement]]'''
*'''[[Effect::Increased libido]]'''
*'''[[Effect::Decreased libido]]''' *'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Uncomfortable physical effects]]'''
*'''[[Effect::Psychosis]]'''
**'''[[Effect::Paranoia]]'''
**'''[[Effect::Delusions]]'''
*'''[[Effect::Irritability]]'''
*'''[[Effect::Memory suppression]]''' - After a few doses, memory becomes impaired in fashion to the MDMA comedown, if more doses are ingested it can be hard to even remember what you are talking about mid sentence.
*'''[[Effect::Motivation enhancement]]'''
*'''[[Effect::Thought acceleration]]'''
*'''[[Effect::Thought organization]]'''
*'''[[Effect::Time distortion]]'''
*'''[[Effect::Wakefulness]]'''
*'''[[Effect::Confusion]]''' - This can be described as being "fried" and it can be hard to even form thoughts properly. This effect usually appears at higher dosage after the first or second peak has passed.

}}
{{effects/aftereffects|

*'''[[Delusions]]'''
**'''[[Effect::Anxiety]]''' - Can cause severe anxiety, especially if coupled with [[psychosis]] or repeated dosages.
*'''[[Effect::Appetite suppression]]'''
*'''[[Effect::Irritability]]'''
*'''[[Effect::Wakefulness]]'''
*'''[[Cognitive fatigue]]'''
*'''[[Effect::Low blood pressure]]''' - This effect is reported by some experience reports, the cathinone family's known vasoconstriction coupled with this can lead to numbness and pale face and hands.

}}
}}

===Experience reports===
Anecdotal reports which describe the effects of this compound within our [[experience index]] include:
{{#ask: [[Category:3-CMC (experience)]][[Category:Experience]]|format=ul|Columns=1}}

Additional experience reports can be found here:

*[https://erowid.org/experiences/subs/exp_3Chloromethcathinone.shtml Erowid Experience Vaults: 3-CMC]

==Toxicity and harm potential==
{{toxicity}}
3-CMC's isomer [[4-CMC]] is a known neurotoxin, and research shows that 3-CMC is neurotoxic in mice<ref>Wojcieszak, Jakub & Kuczyńska, Katarzyna & Zawilska, Jolanta. (2020). Four Synthetic Cathinones: 3-Chloromethcathinone, 4-Chloromethcathinone, 4-Fluoro-α-Pyrrolidinopentiophenone, and 4-Methoxy-α-Pyrrolidinopentiophenone Produce Changes in the Spontaneous Locomotor Activity and Motor Performance in Mice with Varied Profiles. Neurotoxicity Research. 38. 10.1007/s12640-020-00227-8.</ref>. If 3-CMC's mechanism of action is inherently neurotoxic then damage to human health may be incurred even at moderate recreational doses. Anecdotal reports mention highly concerning cardiovascular and neurological symptoms after frequent or high-dose use, which seems to confirm this suspicion.

It is strongly advised to avoid this substance completely. Use excessive [[harm reduction practices]] if planning on using this substance, and avoid redosing.

==Legal status==
{{LegalStub}}
While 3-CMC is not controlled under the United Nations Single Convention on Narcotic Drugs, 1961, nor under the Convention on Psychotropic Substances of 1971. it is subject to restrictive measures in 21 Member States of the European Union: Croatia, Czechia, Denmark, Estonia, France, Italy, Ireland, Latvia, Poland, Portugal, Slovenia, Slovakia, and Sweden. 

*'''China''': Is considered a narcotic substance since 2015{{Citation needed}}
*'''France''': As a derivative of cathinone with a halogen substitution on the phenyl group, 3-CMC is scheduled as a "stupéfiant", i.e. a recognized drug of abuse. It is illegal to possess, buy, sell or manufacture.<ref>{{Citation | title=Arrêté du 22 février 1990 fixant la liste des substances classées comme stupéfiants  | url=https://www.legifrance.gouv.fr/loda/id/JORFTEXT000000533085/2020-11-20/}}</ref>
*'''The Netherlands''': Since 2023-09-12, 3-CMC is classified as a "List 1" drug which makes it illegal.<ref>https://www.officielebekendmakingen.nl/stb-2023-289.html</ref>

==See also==
*[[Responsible use]]
*[[Stimulant]]
*[[Substituted cathinones]]
*[[3-MMC]]
*[[4-MMC]]

==External links==
*[https://en.wikipedia.org/wiki/3-Chloromethcathinone 3-CMC (Wikipedia)]
*[https://isomerdesign.com/pihkal/explore/645 3-CMC (Isomer Design)]

==References==
<references />

Added & revised subjective effects. [[User:Chinker24|Chinker24]] ([[User talk:Chinker24|talk]]) 00:11, 19 January 2023 (UTC)
Added legal status [[User:Bernkastel]] - needs to be conventionalized.