View source for Talk:25H-NBOMe

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{{Headerpanel|{{Warning/25I-NBOMe}}}}
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{{SubstanceBox/25H-NBOMe}}

'''25H-NBOMe''' (also known as '''2C-H-NBOMe''', '''NBOMe-2C-H''') is a novel [[Psychoactive class::psychedelic]] substance of the [[chemical class::phenethylamine]] chemical class that produces an array of stimulating and possibly [[psychedelic]] effects when [[Routes of administration|administered]]. 

It is worth noting that compounds of the [[25x-NBOMe|NBOMe]] family should be administered [[sublingual|sublingually]] by placing and holding it into one's mouth and allowing it to absorb over a period of 15-25 minutes.

Extremely little is known about the pharmacological properties, metabolism, and toxicity of 25H-NBOMe in humans. It had no history of human use before being sold online as a [[designer drug]].{{citation needed}}. It has not officially been associated with fatalities like more common members of the [[25x-NBOMe]] family, possibly because it has never have been distributed a lot. Anecdotal reports suggest that this substance may still be difficult to use safely due to its highly sensitive dose-response and unpredictable effects. 

It should be worth mentioning, that 25H-NBOMe, according to it's pharmacology on one side, might possess stronger pharmacological effects than other 25x-NBOMe compounds, while on the contrary, the little amount of anecdotal experience reports only describe suble or even just negligible stimulating effects, which might be explained when comparing it to related substances like [[2C-H]] and [[2,5-DMA]].{{citation needed}}

==Chemistry==
25H-NBOMe or 2C-H-NBOMe is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as [[2C-H]]. 25H-NBOMe is a substituted phenethylamine with methoxy groups CH<sub>3</sub>O- attached to carbons R<sub>2</sub> and R<sub>5</sub> as well as an iodine atom attached to carbon R<sub>4</sub>. It differs from [[2C-H]] structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group. 25H-NBOMe shares this 2-methoxybenzyl substitution with other chemicals of the NBOMe family. This NBOMe addition contains a methoxy ether CH<sub>3</sub>O- bound to a benzene ring at R<sub>2</sub>.

==Pharmacology==
{{Further|Serotonergic psychedelic}}
25H-NBOMe has efficacy at the [[serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] where it acts as an unusually potent and selective [[Agonist#Agonists|partial agonist]].

According to one paper, 25H-NBOMe has stronger affinity than most other members of the NBOMe family.{{citation needed}}

However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.

Among psychedelics, this compound is considered to be pharmacologically unique in terms of the high potency, affinity, and selectivity with which it binds to the 5-HT2a receptor.{{citation needed}} Contrary to popular belief, it is not a "full agonist"{{citation needed}}, although questions have been raised about how the effects it produces differ from other 5-HT2a partial agonists, which include the range of traditional psychedelics.


==Subjective effects==
{{Preamble/SubjectiveEffects}}


{{effects/base

|{{effects/physical|

*'''[[Effect::Stimulation]]''' - In terms of its effects on the physical energy levels of the user, 25I-NBOMe is usually considered to be very energetic and stimulating. For most people, this substance induces a unique type of physical stimulation which can be described as feeling extremely energetic but in a way which does not force the tripper to move unless they genuinely choose to do so. For others, however, the stimulation can be quite uncontrollable, occasionally resulting in bodily shakes and a grinding of the teeth comparable to that of [[MDMA]] and traditional stimulants such as [[amphetamine]].
*'''[[Effect::Perception of bodily lightness]]''' - In terms of the body’s perceived weight, this substance consistently leaves people feeling extremely light, often to the point of total weightlessness.
*'''[[Effect::Spontaneous physical sensations]]''' - The "body high" itself can be described as a mild, all-encompassing, soft but euphoric tingling sensation. This tingling sensation is also accompanied by spontaneous rushes of [[Physical euphoria|euphoria]] that become longer and more drawn out proportional to the dosage consumed.
*'''[[Effect::Mouth numbing]]''' - Assuming the substance has been taken [[sublingual]]ly, the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very distinct feeling of general numbness of the tongue and mouth which can stay for up ten hours after the blotter paper has been consumed. 
*'''[[Effect::Nausea]]''' - As the user begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, although nausea usually disappears when the user has vomited or the trip fully set in. In comparison to other psychedelics such as [[psilocin]], [[2C-E]] and [[2C-I]], this could actually be considered very mild in its intensity.
*'''[[Effect::Temperature regulation suppression]]'''
**'''[[Effect::Increased bodily temperature]]'''
*'''[[Effect::Abnormal heartbeat]]'''
*'''[[Effect::Increased heart rate]]'''
*'''[[Effect::Increased blood pressure]]'''
*'''[[Effect::Muscle contractions]]'''
*'''[[Effect::Muscle cramps]]'''
*'''[[Effect::Muscle tension]]'''
*'''[[Effect::Gustatory hallucination]]'''
*'''[[Effect::Vasoconstriction]]''' 
*'''[[Effect::Appetite suppression]]'''
*'''[[Effect::Stomach cramps]]'''
*'''[[Effect::Dehydration]]'''
*'''[[Effect::Dry mouth]]'''
*'''[[Effect::Difficulty urinating]]''' or '''[[Effect::Frequent urination]]'''
*'''[[Effect::Restless legs]]'''
*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Headaches]]'''
*'''[[Effect::Seizures]]'''

}}
{{effects/visual|

====Enhancements====
*'''[[Effect::Visual acuity enhancement]]'''
*'''[[Effect::Colour enhancement]]'''
*'''[[Effect::Pattern recognition enhancement]]'''
*'''[[Effect::Magnification]]''' - At higher doses, users can experience a "fish-eye" effect, where magnification changes based on the direction the user is looking relative to the object.

====Suppressions====
*'''[[Effect::Frame rate suppression]]'''
*'''[[Effect::Peripheral information misinterpretation]]'''

====Distortions====
*'''[[Effect::Drifting]]''' ''([[Drifting#Melting|melting]], [[Drifting#Flowing|flowing]], [[Drifting#Breathing|breathing]] and [[Drifting# morphing|morphing]])'' - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance and unrealistic/cartoon-like in style. 
*'''[[Effect::Colour shifting]]'''
*'''[[Effect::Colour replacement]]'''
*'''[[Effect::Colour tinting]]'''
*'''[[Effect::Depth perception distortions]]'''
*'''[[Effect::Perspective distortions]]'''
*'''[[Effect::Tracers]]'''
*'''[[Effect::Diffraction]]'''
*'''[[Effect::Brightness alteration]]'''
*'''[[Effect::After images]]'''
*'''[[Effect::Symmetrical texture repetition]]'''
*'''[[Effect::Recursion]]'''
*'''[[Effect::Scenery slicing]]'''

====[[Effect::Geometry]]====
The visual geometry produced by this substance is similar to [[LSD]] and can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colorful in scheme, glossy in color, sharp around the edges and equally angular as well as rounded across their corners. In comparison to other more commonly used psychedelics they can be described as significantly more intricate than the visual geometry found within [[2C-I]] and most of the [[2C-x]] family in general as well as completely on par with [[LSD]], [[Psilocin]] and [[DMT]] at appropriately high dosages. 

25H-NBOMe’s geometry leads reliably leads to [[Effect::8A Geometry|Level 8A]] visual geometry with [[Level 8B]] remaining so far unconfirmed. It seems to consistently be able to build up in visual intensity when the user stares at a central point. This eventually envelops the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of immersive physical size attributed to it.

====Hallucinatory states====
25H-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently. However, level 4 hallucinatory breakthroughs are reported but very different and inconsistent in comparison to other more commonly used psychedelics such as [[psilocin]], [[2C-E]] and [[DMT]].

These effects include:

*'''[[Effect::Transformations]]'''
*'''[[Effect::Machinescapes]]''' - This component is an uncommon effect that typically only occurs at very strong to heavy doses. It also tends to be accompanied by overwhelming if not dangerous physical and cognitive effects.
*'''[[Effect::Internal hallucination]]''' - (''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]''). These are more common within dark environments and can be described as lucid in believability, interactive in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.

}}
|{{effects/cognitive|

The cognitive effects of 25H-NBOMe are described by many as notably light in comparison to the classical [[psychedelics]]. It is not uncommon for people to report feeling that their thought stream has maintained general normality in its specific style throughout low to moderate dosages. At high dosages, however, strong to overwhelming cognitive alterations become present, which can lead to states of [[confusion]], [[amnesia]], and general sensory overload. 

The most prominent of these cognitive effects generally include:

*'''[[Effect::Analysis enhancement]]''' - This effect is generally only present at low doses.
*'''[[Effect::Thought acceleration]]''' and '''[[Effect::Thought deceleration]]''' - Although one of 25H-NBOME's effects is thought acceleration, the opposite may occur at higher doses.
*'''[[Effect::Conceptual thinking]]''' - This effect is considered to be very mild compared to traditional psychedlics.
*'''[[Effect::Anxiety]]''' & '''[[Effect::Paranoia]]''' - This effect seems to occur more readily than other psychedelics, perhaps due to its very prominent stimulating properties
**'''[[Effect::Feelings of impending doom]]''' - This is generally only experienced during the comedown period or if one has taken a large amount of the substance.
*'''[[Effect::Empathy, affection, and sociability enhancement]]''' - The [[entactogenic]] effects range from mild to powerful, but are inconsistently manifested. Entactogenic effects for people who try this substance usually become prominent in the presence of others. These feelings of increased sociability, love and empathy do not seem to be quite as strong or profound as those found within other [[entactogen|entactogens]] (such as [[MDMA]], [[2C-B]] and [[AMT]])
*'''[[Effect::Memory suppression]]'''
**'''[[Effect::Ego death]]'''
**'''[[Effect::Amnesia]]'''
*'''[[Effect::Novelty enhancement]]'''
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Emotion enhancement]]'''
*'''[[Effect::Increased sense of humor]]'''
**'''[[Effect::Laughter fits]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Personal bias suppression]]'''
*'''[[Effect::Increased libido]]'''
*'''[[Effect::Time distortion]]'''
*'''[[Effect::Wakefulness]]'''

}}
{{effects/auditory|

*'''[[Effect::Auditory enhancement|Enhancements]]'''
*'''[[Effect::Auditory distortion|Distortions]]'''
*'''[[Effect::Auditory hallucinations|Hallucinations]]'''

}}
{{effects/multisensory|

*'''[[Effect::Dosage independent intensity]]''' - While the reasons for this are not understood, many reports suggest that this substance can produce unexpectedly strong or weak effects even when taken at the seemingly same dose in an unpredictable manner.{{citation needed}} This may contribute to the relative risk it is poses compared to most other psychedelics.
*'''[[Effect::Synaesthesia]]''' - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states.

}}
{{effects/transpersonal|
While they are occasionally reported, the transpersonal effects produced by this substance seem to be significantly less consistent and reproducible than other [[psychedelics]], which perhaps corresponds with the notably mild changes to one's perceptual and cognitive processes. 

*'''[[Effect::Existential self-realization]]'''
*'''[[Effect::Unity and interconnectedness]]'''

}}
}}
===Experience reports===
Anecdotal reports which describe the effects of this compound within our [[experience index]] include:
{{#ask: [[Category:25H-NBOMe]][[Category:Experience]]|format=ul|Columns=1}}
Additional experience reports can be found here:

<!-- *[https://www.erowid.org/experiences/subs/exp_25INBOMe.shtml Erowid Experience Vaults: 25H-NBOMe] -->
*[https://erowid.org/experiences/exp.php?ID=102545 Erowid Experience: 25H-NBOMe]

==Toxicity and harm potential==
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
'''Short-term as well as long-term damage of NBOMes have been occasionally tied to serious physical and mental problems on seemingly random people, including memory and speech difficulties, heart problems, HPPD and in some cases Anxiety and PTSD, from particularly difficult experiences.'''

25H-NBOMe is a relatively new substance, and little is known about its pharmacological risks or its interaction with other substances. The [[LD50|LD<sub>50</sub>]] has not yet been determined although it is [[Toxicity::potentially fatal at heavy or very heavy dosages]].<ref>"Fatalities / Deaths". Erowid. April 26, 2013. Retrieved 7 May 2013. | http://www.erowid.org/chemicals/2ci_nbome/2ci_nbome_death.shtml</ref><ref>https://erowid.org/chemicals/nbome/nbome_death.shtml</ref> [[PsychonautWiki]] advises that due to 25H-NBOMe's extreme potency it should not be insufflated as this method of administration appears to have led to several related deaths in the past year.<ref>http://www.erowid.org/chemicals/2ci_nbome/2ci_nbome.shtml/</ref>

The addition of 5-HTP can greatly increase the effects of 25H-NBOME and should be avoided.{{citation needed}}

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.

===Tolerance and addiction potential===
25H-NBOMe is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating. 

Tolerance to the effects of 25H-NBOMe is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::1 week]] for the tolerance to be reduced to half and [[Time to zero tolerance::2 weeks]] to be back at baseline (in the absence of further consumption). 25H-NBOMe presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 25H-NBOMe all psychedelics will have a reduced effect.

===Overdose===
{{NBOMeOD}}

===Dangerous interactions===
{{DangerousInteractions}}
{{DangerousInteractions/Intro}}
{{DangerousInteractions/NBOMe}}

==Legal status==

*'''Canada''': 25H-NBOMe would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.<ref>Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28</ref>
*'''Switzerland''': 25H-NBOMe is a controlled substance defined as a derivative of N-benzylphenethylamine under Verzeichnis E point 130 and 131.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
*'''United Kingdom''': 25H-NBOMe is a Class A drug in the United Kingdom as a result of the N-benzylphenethylamine catch-all clause.<ref>United Kingdom. (2014). Misuse of Drugs Act 1971 (S.I. 2014/1106). London: The Stationery Office Limited. Retrieved July 5, 2017, from http://www.legislation.gov.uk/uksi/2014/1106/made</ref>
*'''United States''': 25H-NBOMe can be controlled under the Federal Analog act.

==See also==

*[[Responsible use]]
*[[Research chemical]]
*[[Psychedelic]]
*[[Phenethylamines]]
*[[25x-NBOMe]]
*[[25I-NBOMe]]

==External links==

*[https://en.wikipedia.org/wiki/25H-NBOMe 25H-NBOMe (Wikipedia)]
*[https://isomerdesign.com/PiHKAL/search.php?domain=pk&id=5386 25H-NBOMe (Isomer Design)]

==References==
{{reflist|2}}

[[Category:Psychoactive substance]]
[[Category:Psychedelic]]
[[Category:25x-NBOMe]]
[[Category:Research chemical]]

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