This is an unofficial archive of PsychonautWiki as of 2025-08-08T03:33:20Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
Talk:Amantadine
From PsychonautWiki Archive
Revision as of 05:21, 22 June 2019 by >Tracer(Created)
It may contain incorrect information, particularly with respect to dosage, duration, subjective effects, toxicity and other risks. It may also not meet PW style and grammar standards.
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Amantadine was first synthesized in 1960s as a antiviral drug for the treatment of influenza. It was serendipitously discovered in 1969 that amantadine possesses central dopaminergicstimulant-like properties and it was introduced for the treatment of Parkinson's disease due to its ability to increase dopamine levels in the brain.
Amantadine is the organic compound adamantan-1-amine, meaning it consists of an adamantane backbone that has an amino group substituted at one of the four methyne positions.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
There are currently no anecdotal reports which describe the effects of this compound within our experience index.
Toxicity and harm potential
Tolerance and addiction potential
The dependence potential for amantadine is unknown.
Amantadine presents cross-tolerance with [[Cross-tolerance::all dissociatives]], meaning that after the consumption of memantine all dissociatives will have a reduced effect.
Dangerous interactions
Amantadine has very limited information on drug combinations and should therefore be treated with extreme caution when combined with other drugs.
Warning:Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
Stimulants - Both stimulants and dissociatives carry the risk of adverse psychological reactions like anxiety, mania, delusions and psychosis and these risks are exacerbated when the two substances are combined.
Depressants - Because both depress the respiratory system, this combination can result in an increased risk of suddenly falling unconscious, vomiting and choking to death from the resulting suffocation. If nausea or vomiting occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.
