Warning
This is an unofficial archive of PsychonautWiki as of 2025-08-08T03:33:20Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.

Deschloroketamine

From PsychonautWiki Archive
Revision as of 21:02, 1 February 2016 by >Josikins
Jump to navigation Jump to search

This article is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

 Template:Proofread
Summary sheet: Deschloroketamine
Deschloroketamine
Chemical Nomenclature
Common names Deschloroketamine, DCK, DXE, O-PCM
Substitutive name Deschloroketamine
Systematic name 2-Phenyl-2-(methylamino)cyclohexanone
Class Membership
Psychoactive class Dissociative
Chemical class Arylcyclohexylamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.


⇣ Smoked
Dosage
Threshold 5 mg
Light 5 - 10 mg
Common 10 - 20 mg
Strong 20 - 40 mg
Heavy 40 mg +
Duration
Total 30 - 90 minutes
⇣ Oral
Dosage
Threshold 10 mg
Light 10 - 20 mg
Common 20 - 30 mg
Strong 30 - 50 mg
Heavy 50 mg +
Duration
Total 4 - 6 hours
Onset 10 - 30 minutes
Come up 30 - 60 minutes
Peak 1.5 - 2.5 hours
Offset 1 - 2 hours
After effects 3 - 24 hours



⇣ Insufflated
Dosage
Threshold 5 mg
Light 10 - 15 mg
Common 15 - 25 mg
Strong 25 - 40 mg
Heavy 40 mg +
Duration
Total 3 - 6 hours
Onset 5 - 15 minutes
Come up 30 - 60 minutes
Peak 1.5 - 2.5 hours
Offset 1 - 2 hours
After effects 3 - 24 hours






DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions
Stimulants
Depressants

Deschloroketamine (DXE, DCK, 2'-Oxo-PCM) is a chemical of the arylcyclohexylamine class which acts as a hallucinogenic dissociative anesthetic.[1][2]

This compound induces a state referred to as "dissociative anesthesia" when ingested and is therefore used as a recreational drug. O-PCE has recently become freely available through online research chemical vendors[1] where it is being sold as a designer drug.[3][4][5] It also acts as an antibiotic.[6]

Chemistry

This chemistry section is incomplete.

You can help by adding to it.

Pharmacology

Main article: NMDA receptor antagonist

Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other arylcyclohexylamine dissociatives such as 3-MeO-PCP, PCP and MXE. With this in mind, O-PCE is thought to act as an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. NMDA receptor antagonists close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually the famous “hole.”

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

Cognitive effects

Visual effects

Suppression

Distortions

Geometry

Hallucinatory states

Auditory effects

Toxicity and harm potential

The toxicity and long-term health effects of recreational 4-MeO-PCP use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 4-MeO-PCP has very little history of human usage. Anecdotal evidence from people who have tried 4-MeO-PCP within the community confirm that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself or using it sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Tolerance and addiction potential

As with other NMDA receptor antagonists, the chronic use of DXE can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings may occur if a person suddenly stops their usage.

Tolerance to many of the effects of DXE develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). Note that DXE presents cross-tolerance with [[Cross-tolerance::all dissociatives]], meaning that after the consumption of DXE all dissociatives will have a reduced effect.

Urinary tract effects

In terms of its long-term health effects when used repeatedly and with excess for extended periods of time, DXE seems to exhibit almost identical bladder and urinary tract problems to those found within ketamine but to a lesser extent. This is because DXE is a little more potent than ketamine, meaning that less of the drug needs to be consumed. Symptoms of ketamine-induced cystitis can become extremely serious and can be described as:

  • Urinary frequency - Urinary frequency is the need to empty the bladder every few minutes.
  • Urinary urgency - This can be described as a sudden, compelling need to urinate.
  • Urinary pressure - This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination.
  • Pelvic and bladder pain - Pain can develop suddenly and severely, particularly as the bladder fills with urine.
  • Hematuria - Hematuria is visible blood in the urine.
  • Incontinence - This is the leakage of urine.

All of these, however, can easily be avoided by simply not using DXE on a daily or even weekly basis and manually limiting one's usage of the substance.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

  • Stimulants - Both stimulants and dissociatives carry the risk of adverse psychological reactions like anxiety, mania, delusions and psychosis and these risks are exacerbated when the two substances are combined.
  • Depressants - Because both depress the respiratory system, this combination can result in an increased risk of suddenly falling unconscious, vomiting and choking to death from the resulting suffocation. If nausea or vomiting occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.

This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Latvia - Deschloroketamine is illegal in Latvia,[7]
  • UK - Deschloroketamine is illegal in the UK.

See also

References

Template:Proofread

Retrieved from "https://psy.st/index.php?title=Deschloroketamine&oldid=74336"