Phencyclidines
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Phencyclidines refers to a class of compounds which typically produce dissociative anaesthesia.
Chemistry
Pharmacology
Examples
- 3-MeO-PCMo
- 3-MeO-PCE
- 3-MeO-PCP
- 4-MeO-PCP
- Ketamine
- Methoxetamine (MXE)
- Methoxyketamine
- Phencyclidine (PCP)
Toxicity and Harm Potential
Psychosis
Certain phencyclidines, including 3-MeO-PCP and PCP, have been reported to cause psychosis and mania at a significantly higher rate than other dissociatives like ketamine, diphenidine, or MXE. There are a significant amount of reports in the medical literature and throughout online forums which describe states of psychosis, mania, delirium, and/or catatonia after abusing these drugs.[1][2][3] In some cases, it has resulted in hospitalization and occasionally has taken up to a week or more to resolve.[4][5][6][7]
In one initial human trial of PCP, it was reported that one-sixth of the patients who had received anaesthetic doses became psychotic.[3] In some cases, it took up to a week or more to resolve. Similar results (although less severe) were reported during trials using subanesthetic doses of PCP for pain relief.[2]
There are numerous reports in the medical literature and throughout online forums, which have identified an increased risk of developing psychotic symptoms when using phencyclidines, arylcyclohexylamines and other NMDA antagonists.
This risk appears to be increased when other substances such as psychedelics, stimulants, and deliriants are combined; and when the drug is used habitually over the course of several days.
Because of this, it is advised that the use of phencyclidines should be kept to a respectable minimum, and that combinations should only be explored by experienced travellers who have carefully and steadily increased their dose over time, fully understand and are prepared for the risks. As always, a sitter is recommended when exploring any new substance or dosage.
Phencyclidines appear to cause trouble more reliably than other NMDA antagonists, likely because of its structural piperidine ring, and because of their potency and duration.
References
| Substance | Source | Circumstance (total dose / duration) | Consequences |
|---|---|---|---|
| PCP | Bluelight thread title | 1 gram over 3 days | Shit got fucked up |
| etc | etc | etc | etc |
See also
References
- ↑ The Big & Dandy 3-MeO-PCP Thread - Part 2 (Bluelight) | http://www.bluelight.org/vb/threads/697059-The-Big-amp-Dandy-3-MeO-PCP-Thread-Part-2
- ↑ 2.0 2.1 The Big & Dandy 3-MeO-PCP Thread - Mad Manic Meo 3nity | http://www.bluelight.org/vb/threads/760934-The-Big-amp-Dandy-3-MeO-PCP-Thread-Mad-Manic-Meo-3nity Cite error: Invalid
<ref>tag; name "two" defined multiple times with different content - ↑ 3.0 3.1 The Big & Dandy 3-MeO-PCP Thread - Part 1 (Bluelight) | http://www.bluelight.org/vb/threads/454099-The-Big-amp-Dandy-3-MeO-PCP-Thread-%28Part-1%29 Cite error: Invalid
<ref>tag; name "one" defined multiple times with different content - ↑ The Big & Dandy 3-MeO-PCP Thread - Part 2 | Page 18 | 10-08-2014 09:10 | Post #448 by Sekio (Administrator) | http://www.bluelight.org/vb/threads/697059-The-Big-amp-Dandy-3-MeO-PCP-Thread-Part-2?p=12523821&viewfull=1#post12523821
- ↑ The Big & Dandy 3-MeO-PCP Thread - Part 2 | Page 20 | 30-08-2014 14:08 | Post #481 by Chocodoobie | http://www.bluelight.org/vb/threads/697059-The-Big-amp-Dandy-3-MeO-PCP-Thread-Part-2?p=12559322&viewfull=1#post12559322
- ↑ The Big & Dandy 3-MeO-PCP Thread - Part 3 | Page 1 | 23-06-2015 11:53 | Post #5 by Confield | http://www.bluelight.org/vb/threads/760934-The-Big-amp-Dandy-3-MeO-PCP-Thread-Mad-Manic-Meo-3nity?p=13108675&viewfull=1#post13108675
- ↑ https://www.erowid.org/experiences/exp.php?ID=103972 | NumbnDumb. "So Strong I'm Shocked: An Experience with 3-MeO-PCP (ID 103972)". Erowid.org. Jan 24, 2016. erowid.org/exp/103972