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Barbiturates

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Death may occur when barbiturates are combined with depressants such as opiates, benzodiazepines, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1]

It is strongly discouraged to consume moderate to heavy dosages of these substances together.

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The structure of barbituric acid

Barbiturates (also referred to as barbies) are a class of drugs that act as central nervous system depressants. Similarly to benzodiazepines, they produce a variety of effects including sleepiness, anxiety suppression, muscle relaxation, seizure suppression and sedation. Barbiturates have been largely replaced by benzodiazepines, generally because benzodiazepines have lower toxicity compared to barbiturates. However, barbiturates are still used today for various medical purposes, mostly for anesthesia.

It's worth noting that the sudden discontinuation of barbiturates can be potentially dangerous or life-threatening for individuals using regularly for extended periods of time, sometimes resulting in seizures or death.[2]

Chemistry

This chemistry section is incomplete.

You can help by adding to it.

Barbiturates are based on the barbituric acid molecule. Commonly, two hydrocarbon substitutions are present at carbon R5. of the pyrimidine ring. It also contains three double-bonded oxygen substitutions at R2, R4 and R6.

Pharmacology

This pharmacology section is incomplete.

You can help by adding to it.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects. These effects are listed and defined in detail within their own dedicated articles below:

Physical effects

Paradoxical effects

Cognitive effects

Toxicity and harm potential

This toxicity and harm potential section is a stub.

As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
Note: Always conduct independent research and use harm reduction practices if using this substance.

Barbiturates are toxic at higher dosages. Barbiturates have a greater addiction potential than benzodiazepines. Overdose can be achieved easier with barbiturates than with benzodiazepines.

Tolerance and addiction potential

high.

Discontinuation

dangerous.

See also

References